Die experimentelle Geschwulstforschung

Domagk, G

doi:10.1007/978-3-642-86854-2_4

Cited by 8 publications

(1 citation statement)

References 660 publications

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“…Interestingly, the ability to develop cancer is inversely correlated to the propensity for regeneration: Cancer has been found only in animals with a low or absent regenerative capacity of complete limbs or head, while animals with a strong ability to rebuild lost limbs hardly ever develop cancer. 106 – 110 This is especially noticeable in hydra, which can replace all limbs without any difficulties. It can be split in many small particles which assemble again to a new organism.…”

Section: Cancer and Embryology And Tissue Renewalmentioning

confidence: 99%

From Reductionism to Holism: Systems-oriented Approaches in Cancer Research

Kienle

Kiene

2012

Glob Adv Health Med

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Somatic mutation theory of cancer has directed cancer research during the last century. A deluge of information on cellular, molecular, and genetic behavior was uncovered, but so was a mind-numbing complexity that still challenges research and concepts, and expectations in the war on cancer have by and large not been fulfilled. A change of paradigm beyond reductionism has been called for, especially as research ubiquitously points at the importance of tissue, microenvironment, extracellular matrix, embryonic and morphogenetic fields, and fields of tissue maintenance and organization in the processes of carcinogenesis, cancer control, and cancer progression, as well as in the control of cellular and genetic behavior. Holistic, organismic systems concepts open new perspectives for cancer research and treatment, as well as general biological understanding.

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Section: Cancer and Embryology And Tissue Renewalmentioning

confidence: 99%