“…Wiltshire (1912-13) observed such low rates due to anisocytosis and poikilocytosis; Bonniger and Herrmann (1923), working with the red cells of chlorosis, Lattes (1925) with spherocytes, and Bunting (1939) with sickle cells, all described similar slow sedimentation. The abnormal and irregular shapes of such red cells probably decrease the area of their flat surfaces in contact with one another, and so inhibit their arrangement in rouleaux.…”