Die Ionisationskonstante des Kodeins

Stucture and Chemotherapeutic Activities of Sulfanilamide Derivatives.

“…This is probably because of rapid absorption and elimination, so that when compared with sulfanilamide the results are poor if given at the same dosage, and reasonably good if given frequently enough. In spite of the low activities reported in this country for ¿V-sulfanilylglycine, it is interesting to note that it has found sale in Sweden under the name Streptasol (5,51).…”

“…(C) Isocyclic substituents These have been synthesized in great variety, since the intermediates are commercially available from the dye industry, or can readily be made from commercial intermediates. For convenience, this class is further subdivided as follows: (1) B, = CnH2"-i to " 2 " 3; (2) oxy and oxo derivatives; (S) carboxy derivatives; (4) sulfo derivatives; (5) CH3(CH2)u-H 0 (40,54) CH3(CH2)17-H 0 (40,54) CH3(CH2) 7CH=CH (CH2)s-H 0 (40,54) hoch2-H…”

“…Table 51 includes all of the A^-acetyl-A^-substituted sulfanilamides, with the latter substituents taken up in the following order: C"H2n-i to C"H2"_i3, (2) oxy or oxo, (3) carboxy, (4) sulfo, (5) amino; (d) heterocyclic substituents; (e) acyl substituents grouped as (1) carbonic acid acyl, (2) acyclic-acyl, (3) isocyclic-acyl, (4) heterocyclic-acyl; and (f) sulfonyl substituents. (F) N4-Sulfonyl-Nl-substituted sulfanilamides (see table 53) Few derivatives have been studied where the A4-sulfonyl group is other than A4-sulfanilyl and in the latter case the compounds are probably behaving as A^substituted sulfanilamides (see section III F).…”

Ion Exchange

“…Steinback and Freisse (267) and Greenbaum et al ( 105) have used an anion exchanger to prepare standard caustic solutions. Salts in organic acids and bases (12) and microanalvsis of the salts of organic acids (284) have been determined using cation exchange resins.…”

Spectrophotometric Determination of Morphine and of Codeine *

“…Csokan (6) published absorption spectra for morphine and codeine in water and alcohol. Ultraviolet spectrophotometric curves of morphine a t various #H values appeared after this work was completed (7). EXPERIMENTAL Ultraviolet Absorption Studies.-All ultraviolet measurements were made over the range from 220 to 325 mp, on a Beckman DU spectrophotometer in 1-cm.…”