Die wichtigsten Darstellungsmethoden

Synthesis and Pharmacological Evaluation of Some Tosylbiurets and Tosylthiocarbamates as Potential Hypoglycemic Agents

“…Two types of derivatives of ptoluenesulfonyl isocyanate have been made and screened as hypoglycemic agents. Some ptoluenesulfonylbiurets were prepared to add to a series of molecules of this type that were previously recorded in the literature (1). These previously synthesized biurets did possess hypoglycemic activity although of a lower order than tolbutamide.…”

Hypoglycaemic Agents. Part III

“…(g) Some I-alkyl-(3-amino-4-methylbenzoyl)-and l-alkyl-(3-amino-4-chlorobenzoy1)-ureas (IX, R = Me or C1; R' = Bu or C,H,,) which bear a formal resemblance to the active hypoglycaemic agent, metahexanamide (X) (Haack, 1958), were obtained by reaction of the appropriate 4-methyl(or chloro)-3-nitrobenzoyl chloride with the alkylurea in benzene-pyridine followed by reduction of the nitro-compounds to the required amines.…”