Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model

Kang, Min‐Cheol; Wijesinghe, W.A.J.P.; Lee, Seung‐Hong; Kang, Sung-Myung; Ko, Seok‐Chun; Yang, Xiudong; Kang, Ning; Jeon, Byong-Tae; Kim, Jaell; Lee, Dae-Ho; Jeon, You‐Jin

doi:10.1016/j.fct.2012.12.012

Cited by 140 publications

(101 citation statements)

References 41 publications

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“…Embryos were incubated for 6 h, the embryo media were changed and the embryos developed up to 2 dpf. Intracellular ROS generation, lipid peroxidation inhibitory activity and cell death in zebrafish embryos were estimated according to the method described by Kang et al, 2013a;Kang et al, 2014;Kim et al, 2014. After incubation, the embryos were rinsed with fresh embryo media and anesthetized before observed under microscope.…”

Section: Estimation Of Intracellular Ros Generation and Lipid Peroximentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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Available online A B S T R A C THigh glucose induced oxidative stress is implicated in intracellular toxicity in tissue and blood vessel such as oxidative stress, lipid peroxidation, and cell death. In this study, we attempted to investigate protective effects of fucoxanthin isolated from Ishige okamurae against high glucose induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and zebrafish model. The ROS generation, lipid peroxidation and cell death were significantly reduced in both the fucoxanthin treated HUVEC and zebrafish in vivo model, compared to those of both negative controls. This study indicates that fucoxanthin could protect cells and organ injury against oxidative stress induced by high glucose in vitro HUVEC and in vivo zebrafish model.

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Section: Estimation Of Intracellular Ros Generation and Lipid Peroximentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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“…It was also reported that herbal medicine was effective as potential therapy for fatty liver disease, diabetes, and metabolic syndrome [15]. Marine algae have also been shown to possess various biological activities such as antiasthmatic, antidiabetic, anticancer, and antioxidant effects [16,17,18]. However, insect-based bioactive products have rarely been studied, owing to a lack of scientific evidence regarding the safety and beneficial effects of insects despite their wide use as traditional foods or medicines in many countries.…”

Section: Introductionmentioning

confidence: 99%

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Seo

Goo

Chung

et al. 2017

IJMS

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Despite the increasing interest in insect-based bioactive products, the biological activities of these products are rarely studied adequately. Larvae of Tenebrio molitor, the yellow mealworm, have been eaten as a traditional food and provide many health benefits. Therefore, we hypothesized that T. molitor larvae might influence adipogenesis and obesity-related disorders. In the present study, we investigated the anti-adipogenic and antiobesity effects of T. molitor larvae in vitro and in vivo. The lipid accumulation and triglyceride content in mature adipocytes was reduced significantly (up to 90%) upon exposure to an ethanol extract of T. molitor larvae, without a reduction in cell viability. Exposure also resulted in key adipogenic and lipogenic transcription factors. Additionally, in adipogenic differentiation medium the extract induced phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and mitogen-activated protein kinases. Daily oral administration of T. molitor larvae powder to obese mice fed high-fat diet attenuated body weight gain. We also found that the powder efficiently reduced hepatic steatosis as well as aspartate and alanine transaminase enzyme levels in mice fed a high-fat diet. Our results suggest that T. molitor larvae extract has an antiobesity effect when administered as a food supplement and has potential as a therapeutic agent for obesity.

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“…This could be possibly related to upregulation of antioxidant enzyme activities by AG-dieckol. Kang et al (2013) reported that increased activities of antioxidant enzymes SOD, CAT, and GSH-px were observed in the treatment with dieckol isolated from E. cava on db/db mice models. The antioxidant property of three edible seaweeds from South East Asia was evaluated by Chew et al (2008).…”

Section: Seaweed Antioxidantsmentioning

confidence: 99%

New insights into seaweed polyphenols on glucose homeostasis

Murugan

Karim

Yusoff

et al. 2015

Pharmaceutical Biology

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Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the activity of hepatic glucose-metabolizing enzymes, lowering the plasma glucose levels, and lipid peroxidation, delaying the aging process. Objective: In this paper, we review the health beneficial effects of polyphenols and phlorotannins from brown seaweeds with special emphasis on their inhibitory effects on carbohydrate-metabolizing enzymes. Methods: A survey of literature from databases such as Sciencedirect, Scopus, Pubmed, Springerlink, and Google Scholar from the year 1973 to 2013 was done to bring together the information relating to drug discovery from brown seaweeds as a source for diabetes treatment. Results: Over the past two decades, 20 different bioactive polyphenols/phlorotannins have been isolated and studied from 10 different brown algae. Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included. Conclusion: Despite the recent advancements in isolating bioactive compounds from seaweeds with potential health benefit or pharmaceutical behavior, studies on the polyphenol effectiveness on glucose homeostasis in human beings are very few in response to their functional characterization. Added research in this area is required to confirm the close connection of polyphenol rich seaweed-based diet consumption with glucose homeostasis and the exciting possibility of prescribing polyphenols to treat the diabetes pandemic.

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Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model

Cited by 140 publications

References 41 publications

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

New insights into seaweed polyphenols on glucose homeostasis

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