Diet containing grape seed meal by-product counteracts AFB1 toxicity in liver of pig after weaning

Ţăranu, Ionelia; Bulgaru, Cristina Valeria; Pistol, Gina Cecilia; Ciceu, Alina; Grosu, Iulian Alexandru

doi:10.1016/j.ecoenv.2020.110899

Cited by 34 publications

(22 citation statements)

References 48 publications

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“…The grape seed meal (GSM) used in this study was provided as dried material by a local distributor (S.C. OLEOMET S.R.L., Bucharest, Romania). The diets composition in polyunsaturated fatty acids (PUFAs) was measured by gas chromatography as described by Taranu et al [ 30 ]. Folin-Ciocalteu and HPLC-DAD-MS analyses were used to determine the total polyphenol content and different classes of polyphenols in experimental diets, as described by Taranu et al [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

“…The diets composition in polyunsaturated fatty acids (PUFAs) was measured by gas chromatography as described by Taranu et al [ 30 ]. Folin-Ciocalteu and HPLC-DAD-MS analyses were used to determine the total polyphenol content and different classes of polyphenols in experimental diets, as described by Taranu et al [ 30 ]. The antioxidant capacity of experimental diets was determined as described by Garcia et al [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

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Dietary Grape Seed Meal Bioactive Compounds Alleviate Epithelial Dysfunctions and Attenuates Inflammation in Colon of DSS-Treated Piglets

Pistol

Bulgaru

Marin

et al. 2021

Foods

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Inflammatory Bowel Diseases (IBD) are chronic inflammations associated with progressive degradation of intestinal epithelium and impairment of the local innate immune response. Restoring of epithelial integrity and of the mucosal barrier function, together with modulation of inflammatory and innate immune markers, represent targets for alternative strategies in IBD. The aim of our study was to evaluate the effects of a diet including 8% grape seed meal (GSM), rich in bioactive compounds (polyphenols, polyunsaturated fatty acids (PUFAs), fiber) on the markers of colonic epithelial integrity, mucosal barrier function, pro-inflammatory, and innate immunity in DSS-treated piglets used as animal models of intestinal inflammation. Our results have demonstrated the beneficial effects of bioactive compounds from dietary GSM, exerted at three complementary levels: (a) restoration of the epithelial integrity and mucosal barrier reinforcement by modulation of claudins, Occludin (OCCL) and Zonula-1 (ZO-1) tight junction genes and proteins, myosin IXB (MYO9B) and protein tyrosine phosphatase (PTPN) tight junction regulators and mucin-2 (MUC2) gene; (b) reduction of pro-inflammatory MMP-2 (matrix metalloproteinase-2) and MMP-9 (matrix metalloproteinase-9) genes and activities; and (c) suppression of the innate immune TLR-2 (Toll-like receptor-2) and TLR-4 (Toll-like receptor-4) genes and attenuation of the expression of MyD88 (Myeloid Differentiation Primary Response 88)/MD-2 (Myeloid differentiation factor-2) signaling molecules. These beneficial effects of GSM could further attenuate the transition of chronic colitis to carcinogenesis, by modulating the in-depth signaling mediators belonging to the Wnt pathway.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Dietary Grape Seed Meal Bioactive Compounds Alleviate Epithelial Dysfunctions and Attenuates Inflammation in Colon of DSS-Treated Piglets

Pistol

Bulgaru

Marin

et al. 2021

Foods

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“…The polyphenol profile of GSM, expressed as catechin equivalents (CE), obtained through LC-MS analysis revealed a high content of phenolic acids such as caffeoilquinic acid (57.4 μg ml −1 CE), ferulic acid (34.43 μg ml −1 CE), dicaffeoilquinic acid (28.85 μg ml −1 CE), along with procyanidin dimers (30.25 μg ml −1 CE) and trimers (13.02 μg ml −1 CE). In the flavan-3-ol class, catechin content was 13.61 μg ml −1 CE, while epigallocatechin was 22.28 μg ml −1 CE (Taranu et al, 2020b(Taranu et al, , 2019.…”

Section: Chemical Composition Of Grape Seed Mealmentioning

confidence: 97%

“…Linoleic acid was the most abundant ω-6 FA (62.94%), whereas alphalinolenic acid was the predominant ω-3 fatty acid (0.85%). Among the monounsaturated fatty acids (MUFA), oleic acid (ω-9) was also present with a concentration of 15.30% (Taranu et al, 2020b(Taranu et al, , 2019.…”

Section: Chemical Composition Of Grape Seed Mealmentioning

confidence: 99%

“…For instance, grape pomace has been reported as a new potentially efficient bio-sorbent for the removal of mycotoxins from liquid media (Avantaggiato et al, 2014). Similarly, grape seed cakes and grape seed meal (GSM) that are obtained from the oil extraction from grape seeds is a by-products rich in bioactive compounds, such as polyphenols as well as polyunsaturated fatty acids (PUFAs), which possess anti-inflammatory, anti-cancer, anti-microbial, antioxidative and immune-modulatory activities (Taranu et al, 2020a(Taranu et al, , 2020b. More recently, the successful evaluation of adsorption efficacy was investigated on AFB1, among other tested mycotoxins, using chitosan which mediated its removal from palm kernel cake (Abbasi Pirouz et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Response of antioxidant status in kidney of pigs exposed to aflatoxin B1 to dietary grape seed meal

Palade

Perțea

Ţăranu

2021

Archiva Zootechnica

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This study investigated the effects of dietary inclusion of grape seed meal (GSM) on antioxidant markers in kidney of aflatoxin B1 fed pigs. Twenty-four cross-bred pigs (TOPIG-40) were randomly assigned to one of the four experimental diets: control (Control), aflatoxin B1 (diet contaminated with 320 μg AFB1/kg feed), grape seed meal (diet with 8% GSM) and AFB1+GSM (320 μg AFB1/kg feed + 8% GSM) for 30 days. Aflatoxin B1 induced oxidative damage and showed lower antioxidant status in kidney after 30 days. CAT and SOD activity measured in kidneys revealed significant differences when comparing the GSM+AFB1 group with the AFB1 group. Additionally, GSM diet alone did not affect CAT and SOD levels in kidneys of piglets compared with the control group, suggesting that they are maintained at physiological levels. We did not detect any effects of GSM on GPx and TAS. Including GSM into piglets’ diet significantly lowered lipid peroxidation induced by AFB1, while it did not affect it compared with the control group. The present study demonstrated the ability of GSM to alleviate the effects induced by the toxin evidenced by the improvement in the antioxidant status, and suggests the potential applicability of GSM as mycotoxin adsorbent in animal feed.

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Food and Feed Additives to Counteract Mycotoxin Toxicity in Human and Animals

Marin,

Taranu

2023

Sustainable Use of Feed Additives in Livestock

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Diet containing grape seed meal by-product counteracts AFB1 toxicity in liver of pig after weaning

Cited by 34 publications

References 48 publications

Dietary Grape Seed Meal Bioactive Compounds Alleviate Epithelial Dysfunctions and Attenuates Inflammation in Colon of DSS-Treated Piglets

Dietary Grape Seed Meal Bioactive Compounds Alleviate Epithelial Dysfunctions and Attenuates Inflammation in Colon of DSS-Treated Piglets

Response of antioxidant status in kidney of pigs exposed to aflatoxin B1 to dietary grape seed meal

Food and Feed Additives to Counteract Mycotoxin Toxicity in Human and Animals

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