2020
DOI: 10.1017/s1368980020003420
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Diet-dependent acid load and the risk of colorectal cancer and adenoma: a case–control study

Abstract: Objectives: Colorectal cancer (CRC) is the third and second most prevalent cancer in men and women, respectively. Various epidemiological studies indicated that dietary factors are implicated in the aetiology of CRC and its precursor, colorectal adenomas (CRA). Recently, much attention has been given to the role of acid–base balance in the development of chronic diseases including cancers. Therefore, the aim of the current study is to examine the association of diet-dependent acid load and the risk of CRC… Show more

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Cited by 12 publications
(27 citation statements)
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“…Two studies were also removed during the second screening phase because these studies were conference. Finally, three cohorts ( 21 , 24 , 30 ) and seven case-control studies ( 19 , 20 , 22 , 23 , 31 33 ) were comprised in the current systematic review and meta-analysis. Figure 1 shows the flow diagram of the study selection process.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Two studies were also removed during the second screening phase because these studies were conference. Finally, three cohorts ( 21 , 24 , 30 ) and seven case-control studies ( 19 , 20 , 22 , 23 , 31 33 ) were comprised in the current systematic review and meta-analysis. Figure 1 shows the flow diagram of the study selection process.…”
Section: Resultsmentioning
confidence: 99%
“…It has been shown that greater intake of a diet with high acid load may contribute to the increased risk of health conditions such as cardiovascular diseases ( 15 ), hypertension ( 16 ), chronic kidney disease ( 17 ), and diabetes mellitus ( 18 ). Multiple investigations have recently studied the association between the DAL and the risk of various cancers ( 19 24 ). However, to our knowledge, there has been no comprehensive report summarizing these studies.…”
Section: Introductionmentioning
confidence: 99%
“…The existing epidemiologic evidence related to acid load and cancer risk is limited, restricted to BC [21,23,25], colorectum [34,35], and pancreas [36]. The research works related to BC are not consistent enough [21,[23][24][25].…”
Section: Discussionmentioning
confidence: 99%
“…There were positive associations for acid load with BC risk among American and Puerto Rican women [21,23], but it was not associated among Iranian ones [25]. Some studies reported results about the influence of the acid load on the metabolic condition (hyperinsulinism and/or diabetes) [34,35] and the association with BC recurrence and survival [23,24]. One of these, identified acid load as a novel dietary factor that may lead to inflammation and hyperglycemia [23].…”
Section: Discussionmentioning
confidence: 99%
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