Diet quality is not associated with late-onset multiple sclerosis risk– A Danish Cohort Study

Pommerich, Uwe Martin; Nielsen, Rasmus Oestergaard; Overvad, Kim; Dahm, Christina C.; Tjønneland, Anne; Olsen, Anja; Dalgas, Ulrik

doi:10.1016/j.msard.2020.101968

Cited by 11 publications

(5 citation statements)

References 91 publications

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“…Diet in MS can be assessed via many instruments, such as the Dietary Questionnaire for Epidemiological Studies [ 7 ], food diaries, and shorter measures such as the Short‐Form Food Frequency Questionnaire [ 8 ] and the Diet Habits Questionnaire (DHQ) [ 9 ], used in the present study. Multiple studies have identified associations between diet and MS risk [ 10 , 11 ] disability [ 12 ], fatigue [ 12 , 13 , 14 ], and depression [ 12 , 15 ]; others have found no associations [ 14 , 15 , 16 , 17 , 18 ]. Our group has evaluated the cross‐sectional relationships of diet and disability [ 19 , 20 ], depression [ 21 ], and fatigue [ 22 ] at baseline using the Health Outcomes and Lifestyle In a Sample of people with Multiple sclerosis (HOLISM) cohort, finding that a higher DHQ score was associated with better outcomes.…”

Section: Introductionmentioning

confidence: 99%

Higher‐quality diet and non‐consumption of meat are associated with less self‐determined disability progression in people with multiple sclerosis: A longitudinal cohort study

Simpson‐Yap

Nag

Probst

et al. 2021

Euro J of Neurology

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Background and purpose: Modifiable lifestyle factors, including diet, may affect clinical outcomes in multiple sclerosis (MS). This study assessed the relationships between diet, and disability, fatigue, and depression risk in people with MS.Methods: Participants from the Health Outcomes and Lifestyle In a Sample of people with Multiple sclerosis (HOLISM) international cohort were assessed over 2.5 years.Dietary data were obtained using a modified Diet Habits Questionnaire (DHQ), disability using the calculated Patient-determined MS Severity Score (P-MSSS), fatigue using the Fatigue Severity Scale, and depression risk using the Patient Health Questionnaire-2.Participants reported whether they were experiencing symptoms due to a recent relapse. Cross-sectional and prospective relationships of diet and disease outcomes were explored, adjusted for relevant confounders.Results: Among 1,346 participants, higher DHQ scores showed significant dosedependent associations with lower frequencies of severe disability, fatigue, and depression risk, cross-sectionally. Prospectively, higher baseline DHQ scores were associated with a lower risk of increasing disability, those above the median having 41% and 36% lower risk of increasing disability, and 0.30 P-MSSS points less disability progression, but were not associated with fatigue or depression risk. Meat consumption was associated with 0.22 P-MSSS points higher disability cross-sectionally, while prospectively, baseline meat consumption was associated with 76% higher risk of increasing disability and 0.18 P-MSSS points higher disability progression. Dairy consumption showed mixed associations cross-sectionally and prospectively.Conclusions: These results show that better quality of diet, as well as not consuming meat, were associated with reduced disability progression in people with MS. Substantiation of these findings in other settings may inform opportunities to manage disability progression in people with MS using dietary modifications.

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Section: Introductionmentioning

confidence: 99%

Higher‐quality diet and non‐consumption of meat are associated with less self‐determined disability progression in people with multiple sclerosis: A longitudinal cohort study

Simpson‐Yap

Nag

Probst

et al. 2021

Euro J of Neurology

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“…The mean age of patients have been reported at 55.3 ± 4.45, 10 74 ± 4.9, 11 53.5 ± 3.1, 12 55.1 ± 4.3 13 in Canada, Denmark, Israel, and Iran, respectively. Compared to our study, these findings are similar except for the study conducted in Denmark which can a point of further investigation in future studies in this region.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Epidemiological Aspects of Late Onset Multiple Sclerosis in East-Azerbaijan, Iran; A Population-Based Study

et al. 2022

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Background: Late-onset multiple sclerosis (LOMS) is defined as symptoms initiating at an age above 50. Objective: This study aims to determine the clinical and epidemiological aspects of LOMS in East-Azerbaijan province, Iran. Methods: This population-based study recruited nearly all MS patients to the end of 2020, who were diagnosed at age≥50, by referring to the only local MS registry center. We investigated prevalence, sex, age-of-onset, first clinical presentation, family history, and gap of diagnosis. Also, we compared the disease characteristics between male and female cases. Results: Out of 4905 total cases of MS, 217 cases (4.42%) were LOMS. The mean age of onset was 53.80±3.41 years with a maximum age of 68 years. The most common age group of the patients was 50 to 55 years (69.1%). The frequency by sex of LOMS in females (150) was greater than males (67). Positive family history was seen in 6.17%, and in 41% of the patients, the disease was diagnosed in a timely manner. Early symptoms were motor (31.3%), sensory (24.8%), optic neuritis (23%), cerebellar symptoms (13.8%), and brainstem symptoms (6.9%). The first presentation of the disease was different between male and female cases (P-value<0.01). Motor symptoms were the most prevalent first clinical presentation in female cases (37.6%), while in male cases, cerebellar symptoms (25.8%) were the most common. Conclusion: LOMS is not a rare condition. Increasing knowledge in the diagnosis, as well as increasing awareness of the disease in the general population, leads to early diagnosis of LOMS and prevention of consequences.

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“…Not all trials and prospective studies have yielded clear findings to inform dietary guidelines. Most notably, two prospective cohort studies among 56,867 Danish adults and 185,000 US women found no association between diet quality and MS risk [176,177] . The infrequent incidence of MS incidence in both studies (0.2%) may underlie these null findings.…”

Section: Human Ms Dietary Studiesmentioning

confidence: 99%

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Plafker¹,

Titcomb²,

Zyla-Jackson³

et al. 2023

Immunometabolism

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This review summarizes the cellular and molecular underpinnings of autoimmune demyelinating optic neuritis (ADON), a common sequela of multiple sclerosis and other demyelinating diseases. We further present nutritional interventions tested for people with multiple sclerosis focusing on strategies that have shown efficacy or associations with disease course and clinical outcomes. We then close by discuss the potential dietary guidance for preventing and/or ameliorating ADON.

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Diet quality is not associated with late-onset multiple sclerosis risk– A Danish Cohort Study

Cited by 11 publications

References 91 publications

Higher‐quality diet and non‐consumption of meat are associated with less self‐determined disability progression in people with multiple sclerosis: A longitudinal cohort study

Higher‐quality diet and non‐consumption of meat are associated with less self‐determined disability progression in people with multiple sclerosis: A longitudinal cohort study

Clinical and Epidemiological Aspects of Late Onset Multiple Sclerosis in East-Azerbaijan, Iran; A Population-Based Study

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

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