Dietary Antioxidants: Potential Anticancer Agents

Wu, Xiayu; Cheng, Jiaoni; Wang, Xu

doi:10.1080/01635581.2017.1299872

Cited by 51 publications

(33 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The animal model study further demonstrated that feeding Apc/Kras G 12 D mutant mice high-dose ascorbic acid may impair tumor growth (Yun et al, 2015 ). Consistent with the data reported by Yun et al ( 2015 ) and Ma Y. et al ( 2014 ), Wu et al ( 2017 ) identify an antitumor activity of ascorbic acid in a clinical study. Although the molecular link underlying ascorbic acid and anticancer activity require further elucidation, most of the experimental studies indicate that modulating oxidative stress could play a crucial role (Badgujar et al, 2015 ; Huang et al, 2017 ).…”

Section: Role Of Antioxidants In the Prevention Of Age-related Diseassupporting

confidence: 83%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

View full text Add to dashboard Cite

Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.

show abstract

Section: Role Of Antioxidants In the Prevention Of Age-related Diseassupporting

confidence: 83%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

View full text Add to dashboard Cite

show abstract

“…59 Moreover, organic acids present in natural matrices are involved in the reduction of oxidative stress. 60 Phenolic compounds which contribute directly to antioxidative protection and play an important role in stabilizing lipid peroxidation were also determined in the studied sample, 11 being identified as p-hydroxybenzoic acid and p-coumaric acid (Table 2). Similarly, Fernandes et al 24 described p-hydroxybenzoic acid as the main phenolic acid in samples of P. squamosus of different origins, while cinnamic acid, a phenolic-related compound, was also found in small amounts.…”

Section: Chemical Composition Of Polyporus Squamosusmentioning

confidence: 99%

Chemical composition and bioactive properties of the wild mushroom Polyporus squamosus (Huds.) Fr: a study with samples from Romania

et al. 2018

View full text Add to dashboard Cite

In Eastern Europe, wild mushrooms are widely collected in mountain areas and used for their medicinal properties or as healthy foods. This study aimed at determining the chemical composition (nutritional value, free sugars, organic acids, phenolic compounds, fatty acids and tocopherols) and bioactive properties (antioxidant, antimicrobial and antiquorum sensing) of wild Polyporus squamosus (Huds.) Fr from Romania. The results indicate that the fruiting bodies of P. squamosus are rich in carbohydrates (74.22 g per 100 g dw) and proteins (18.7 g per 100 g dw). Trehalose was the main free sugar, while malic acid was the organic acid detected in the highest amount (2.21 g per 100 g dw), and p-hydroxybenzoic acid was the main phenolic compound. Among tocopherols, β-tocopherol was the most abundant form (114.7 μg per 100 g dw). Additionally, regarding the fatty acids' pattern, polyunsaturated acids represent more than 57% of all fatty acids, followed by monounsaturated fatty acids (24.96%). The highest measured antioxidant effect of P. squamosus extract was found using the TBARS inhibition assay (EC = 0.22 mg mL), followed by the β-carotene/linoleate assay (EC = 1.41 mg mL). A minimal inhibitory concentration of the tested extracts was obtained between 0.61-20.4 mg mL, while the bactericidal effect was achieved between 1.2-40.8 mg mL. Antibiofilm potential was obtained at all tested concentrations, and subinhibitory concentrations of the extract exhibited an antiquorum effect and reduced the formation of P. aeruginosa pili, which all together influenced the virulence of this bacterium. Due to the investigated bioactivities and compounds of P. squamosus and its well-balanced nutritional profile, this mushroom can be further used as a medicinal ingredient based on its antioxidative and antimicrobial potential.

show abstract

“…Polyphenols are the most studied nutraceuticals so far and many beneficial effects on various diseases have been reported in the literature, along with the problems and limits related to their use as drugs [ 30 ]. We refer to recent reviews for their anti-cancer effects, as they are able to modulate multiple coding and non-coding genes, ultimately targeting the main hallmarks of cancer [ 31 , 32 , 33 , 34 , 35 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

Use of Nutraceuticals in Angiogenesis-Dependent Disorders

2018

View full text Add to dashboard Cite

The term of angiogenesis refers to the growth of new vessels from pre-existing capillaries. The phenomenon is necessary for physiological growth, repair and functioning of our organs. When occurring in a not regulated manner, it concurs to pathological conditions as tumors, eye diseases, chronic degenerative disorders. On the contrary insufficient neovascularization or endothelial disfunction accompanies ischemic and metabolic disorders. In both the cases an inflammatory and oxidative condition exists in supporting angiogenesis deregulation and endothelial dysfunction. The use of nutraceuticals with antioxidant and anti-inflammatory activities can be a therapeutic option to maintain an adequate vascularization and endothelial cell proper functioning or to blunt aberrant angiogenesis. A revision of the updated literature reports on nutraceuticals to guide endothelial cell wellness and to restore physiological tissue vascularization is the objective of this paper. The critical aspects as well as lacking data for human use will be explored from a pharmacological perspective.

show abstract

Dietary Antioxidants: Potential Anticancer Agents

Cited by 51 publications

References 86 publications

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Chemical composition and bioactive properties of the wild mushroom Polyporus squamosus (Huds.) Fr: a study with samples from Romania

Use of Nutraceuticals in Angiogenesis-Dependent Disorders

Contact Info

Product

Resources

About