Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells

Quesada, Isabel; Bustos, Mario; Blay, Mayte; Pujadas, Gerard; Ardèvol, Anna; Salvadó, M. Josepa; Bladé, Cinta; Arola, Lluı́s; Fernández-Larrea, Juan

doi:10.1016/j.jnutbio.2009.12.009

Cited by 41 publications

(35 citation statements)

References 63 publications

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“…In the present study, cellular zinc levels rapidly decreased in the AGE groups, which might be responsible for endothelial cell dysfunction. It has been reported that high oxidative stress results in release of zinc from metallothionein (Jomova and Valko, 2011), and the antioxidant scavenges free radicals and increases the levels of intracellular labile zinc (Quesada et al, 2011). Considering our observations that zinc levels were reduced, eNOS enzymatic activity was inhibited, and NO production was diminished, it was conjecturable that when the cells were exposed to AGEs, the subsequent imbalance in cellular oxidative stress induced a release of zinc from the tetrahedral conformation, leading to eNOS inactivation.…”

Section: Discussionmentioning

confidence: 61%

Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction

et al. 2012

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Section: Discussionmentioning

confidence: 61%

Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction

et al. 2012

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“…We report a more than 50% decrease in response to GSPE of SLC30A1, the transporter that exports zinc ions out of cells. Previous results in our group showed a decrease in the mRNA level of this zinc transporter and an increase in labile zinc cytosolic levels in HepG2 hepatocytes treated with GSPE, and we hypothesized that through these changes in labile zinc levels GSPE would affect signaling processes and/or metabolic pathways modulated by zinc (83).…”

Section: Discussionmentioning

confidence: 88%

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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Bioactive proanthocyanidins have been reported to have several beneficial effects on health in relation to metabolic syndrome, type 2 diabetes, and cardiovascular disease. We studied the effect of grape seed proanthocyanidin extract (GSPE) in rats fed a high fat diet (HFD). This is the first study of the effects of flavonoids on the liver proteome of rats suffering from metabolic syndrome. Three groups of rats were fed over a period of 13 weeks either a chow diet (control), an HFD, or a high fat diet supplemented for the last 10 days with GSPE (HFD ؉ GSPE). The liver proteome was fractionated, using a Triton X-114-based two-phase separation, into soluble and membrane protein fractions so that total proteome coverage was considerably improved. The data from isobaric tag for relative and absolute quantitation (

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“…GT polyphenols also play a role in reducing cellular levels of ROS generating redox-active metals. Quesada et al [18] determined that EGCG binds to zinc cations with high affinity thereby reducing the accumulation of zinc in a human liver hepatocellular carcinoma (HepG2) cell model. Another study reported by Wei and Meng [19] showed that EGCG reversed lead-induced oxidative damage in ventricular myocytes isolated from rat hearts and reduced OH, O 2…”

Section: Oxidative Stressmentioning

confidence: 99%

Green Tea as an Agricultural Based Health Promoting Food: The Past Five to Ten Years

Shi

Schlegel

2012

Agriculture

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Abstract:The consumption of tea originated in ancient China over 4000 years ago and is currently the second most popular beverage in the world after water. Tea is an aromatic beverage prepared by pouring hot water over cured leaves of the Camellia sinensis plant. The link between tea intake, most notably green tea, and health has resulted in intense research on the components responsible for preventing the onset of several chronic diseases, including atherosclerosis, cancer, obesity and diabetes. In particular, the high levels of chemically diverse phenols (e.g., phenolic acids, flavonoids) present in tea exhibit potent protective properties against many of these diseases. Although health related research on green tea and its predominant phenol (catechins) has been on-going for decades, major advances have occurred in the last 5-10 years. Therefore, this review focuses on seminal studies reported primarily within the last five years but not extending past ten years on the link between health and green tea with an emphasis on the catechins.

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Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells

Cited by 41 publications

References 63 publications

Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction

Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Green Tea as an Agricultural Based Health Promoting Food: The Past Five to Ten Years

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