Dietary exposure to silver nanoparticles in Sprague–Dawley rats: Effects on oxidative stress and inflammation

Elle, Raymond Ebabe; Gaillet, Sylvie; Vidé, Joris; Romain, Cindy; Lauret, Céline; Rugani, Nathalie; Cristol, Jean‐Paul; Rouanet, Jean-Max

doi:10.1016/j.fct.2013.07.071

Cited by 98 publications

(41 citation statements)

References 37 publications

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“…The connection between increased ROS levels and the release of inflammatory mediators such as interleukin-6, tumor necrosis factor-alpha [95], interleukin-1β and macrophage inhibitory protein (MIP-2) in macro-phages [15] has been observed. The AgNP-mediated inflammatory response was also observed in rodent liver [30,56,67,71] and lungs [132], and increased expression of cytokines was observed in serum [25,39,99].…”

Section: Agnp-induced Inflammation and Cell Deathmentioning

confidence: 85%

“…This mechanism of AgNPs toxicity may be confirmed by the fact that weak antioxidants with -SH groups such as 2,3-dithiopropanol [26], N-acetylcysteine (NAC) [62], methionine and cysteine are more effective against AgNP-induced cytotoxicity than the most potent antioxidants without thiol groups such as Trolox (water soluble vitamin E analog) or Tempol [126]. Overproduction of ROS during exposure to AgNPs has been proven directly in several in vitro investigations [15,26,78,141] and also in vivo [30,103]. Among the oxidative stress-related changes caused by AgNPs, depletion of reduced glutathione (GSH) has been observed in human skin carcinoma cells [6], rat liver cells [60], mouse macrophage cells [100], human liver cells [106,141] and mouse embryonic fibroblasts [74].…”

Section: -Body Weight Gsh -Reduced Glutathione Ige -Immunoglobulin mentioning

confidence: 92%

“…Adverse effects were observed including marked pathological changes in liver morphology [32,67,71], changes in liver enzyme activities [2,56,99], changes in the level of plasma lipids [30,67], generation of ROS [30,103] and inflammatory response [25,99]. Autophagy and apoptosis have been confirmed to play roles in mediating hepatotoxicity [71].…”

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

“…Table III lists studies demonstrating the negative influence of AgNPs in mammalian organisms. A series of studies has shown that systematically administered AgNPs cause inflammatory and cytotoxic effects including pulmonary toxicity after prolonged inhalation [132] and hepatotoxicity after prolonged oral [30,67,103], intravenous [25] or intraperitoneal [32] administration. Moreover, histopathological changes in kidneys and increasing levels of creatinine have been reported [33,119], indicating that AgNPs may cause nephrotoxic effects.…”

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

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Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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A b s t r a c t Over the last decade, silver nanoparticles have become an important class of nanomaterials utilized in the development of new nanotechnologies. Despite the fact that nanosilver is used in many commercial applications, our knowledge about its associated risks is incomplete. Although a number of studies have been undertaken to better understand the impact of silver nanoparticles on the environment, aquatic organisms and cell lines, little is known about their side effects in mammalian organisms. This review summarizes relevant data and the current state of knowledge regarding toxicity of silver nanoparticles in mammals, as well as the accumulated evidence for potent neurotoxic effects. The influence of nanosilver on the central nervous system is significant because of evidence indicating that it accumulates in mammalian brain tissue.

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Section: Agnp-induced Inflammation and Cell Deathmentioning

confidence: 85%

Section: -Body Weight Gsh -Reduced Glutathione Ige -Immunoglobulin mentioning

confidence: 92%

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

Section: Toxic Effects Of Silver Nanoparticles In Mammalsmentioning

confidence: 99%

See 2 more Smart Citations

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Skalska¹,

Strużyńska²

2015

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“…The results showed liver damage by a dysregulation of lipid metabolism, highlighting liver and heart as the most sensitive organs to the deleterious effects [47] Food Eng Rev packaging, considerable research has not yet been done on the safety of nanocomposite materials. Experimental tests are needed to ensure the safety of such packaging materials.…”

Section: Discussionmentioning

confidence: 97%

Nanocomposite Materials for Food Packaging Applications: Characterization and Safety Evaluation

Farhoodi

2015

Food Eng Rev

108

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Food packaging requires long shelf life and the monitoring of safety and quality based on international standards. In the past decade, polymer nanocomposites have emerged as a new class of food packaging materials, because they have several advantages, such as enhanced mechanical, thermal, and barrier properties. The larger surface area of nanoparticles compared with their microscale counterparts favours filler-matrix interactions and the performance of the resulting material. A new technology is accepted by the community once it has been tested for its effects on health. There have been some studies on the migration of nanoparticles from packaging material into food/food simulants during storage. It is very important to evaluate the safety of nanocomposite packaging materials used for food products. This review summarizes the characteristics and properties of nanocomposite packaging materials along with their safety problems for food consumers.

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Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Singh,

Pandit,

Balusamy

et al. 2024

Adv Healthcare Materials

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Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed of gold, silver, and iron oxide, have emerged as promising candidates for changing cancer therapy. This comprehensive review demonstrates the landscape of nanoparticle‐based oncological interventions, focusing on the remarkable advancements and therapeutic potentials of gold, silver, and iron oxide nanoparticles. Gold nanoparticles have garnered significant attention for their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, rendering them ideal candidates for various cancer diagnostic and therapeutic strategies. Silver nanoparticles, renowned for their antimicrobial properties, exhibit remarkable potential in cancer therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, and drug delivery enhancement. With their magnetic properties and biocompatibility, iron oxide nanoparticles offer unique cancer diagnosis and targeted therapy opportunities. This review critically examines the recent advancements in the synthesis, functionalization, and biomedical applications of these nanoparticles in cancer therapy. Moreover, the challenges are discussed, including toxicity concerns, immunogenicity, and translational barriers, and ongoing efforts to overcome these hurdles are highlighted. Finally, insights into the future directions of nanoparticle‐based cancer therapy and regulatory considerations, are provided aiming to accelerate the translation of these promising technologies from bench to bedside.

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Dietary exposure to silver nanoparticles in Sprague–Dawley rats: Effects on oxidative stress and inflammation

Cited by 98 publications

References 37 publications

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Toxic effects of silver nanoparticles in mammals – does a risk of neurotoxicity exist?

Nanocomposite Materials for Food Packaging Applications: Characterization and Safety Evaluation

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

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