Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women

Paula, Roberta; Souza, Vinícius Carolino; Benedet, Andréa Lessa; Souza, Elias Rosa de; Toledo, Juliana Oliveira; Moraes, Clayton Franco; Gomes, Lucy; Alho, Clarice Sampaio; Córdova, Cláudio; Nóbrega, Otávio de Tolêdo

doi:10.1007/s11010-009-0313-0

Cited by 18 publications

(20 citation statements)

References 43 publications

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“…A study with elderly Brazilian women found that triglyceride values were higher in ε2 carriers than in ε4 carriers [34]. In contrast, no obvious relationship between APOE status and serum triglycerides was reported in a study with patients with metabolic syndrome [35], which is in line with our findings.…”

Section: Discussionsupporting

confidence: 90%

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia

et al. 2017

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BackgroundSchizophrenia is a serious mental disorder largely manageable with atypical antipsychotics; however, these drugs have been associated with glucose/lipid metabolism issues such as diabetes and hyperlipidaemia. Apolipoprotein E (APOE) is the most abundant apolipoprotein, and APOE genotypes have been correlated with lipid metabolism phenotypes in an age-dependent manner. Studies examining the relationship between the APOE genotype and lipid abnormalities in patients with schizophrenia have been inconclusive, but primarily focused on adult patient populations. Therefore, we explored the correlations between the APOE genotype and glucose/lipid metabolism indicators and abnormalities in hospitalized patients 60 years or older with schizophrenia with a history of long-term antipsychotics use.MethodsWe assessed APOE genotype, age, weight, height, blood glucose, triglycerides, cholesterol, high-density lipoprotein, and low-density lipoprotein in a total of 294 patients. APOE genotypes were divided into three groups: APOE ε2 (ε2/ε2 and ε2/ε3), APOE ε3 (ε3/ε3), and APOE ε4 (ε3/ε4 and ε4/ε4), and comparisons were conducted among these groups or according to ε2 carrier status.Results APOE ε3/ε3 was the most common genotype (68.3%) and at least one ε3 allele was present in 81.8% of patients. There were no differences in antipsychotics type or dose according to the APOE genotype, but serum cholesterol values varied near significantly (P = 0.052) and low-density lipoprotein values varied significantly according to genotype (P < 0.05, lowest in the APOE ε2 genotype). Men had lower cholesterol and low-density lipoprotein levels (P < 0.05) than women. Compared to patients administered typical antipsychotics, those administered atypical antipsychotics had higher triglyceride, cholesterol, and low-density lipoprotein levels (P < 0.05). Stepwise linear regressions showed that cholesterol and low-density lipoprotein levels were influenced by sex, the APOE ε2 genotype, and atypical antipsychotics use.ConclusionsIn the context of atypical antipsychotics use, carriers of the APOE ε2-genotype and male patients with schizophrenia 60 years or older may be less likely to develop a lipid metabolism abnormality.

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Section: Discussionsupporting

confidence: 90%

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia

et al. 2017

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“…However, an abbreviated 4-hour PPL test seems to be a valid surrogate for an 8-hour test 32. Finally, variations in genes such as those encoding the apolipoproteins A, B and E may directly affect PPL due to their involvement in lipid metabolism 31,33. Therefore, studies using longer postprandial times and examining allelic variations should be conducted to better understand the different PPL mechanisms.…”

Section: Discussionmentioning

confidence: 99%

The influence of intense intermittent versus moderate continuous exercise on postprandial lipemia

Ferreira

Ferreira²,

Souza³

et al. 2011

Clinics

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INTRODUCTION:Postprandial lipemia is characterized by an increased concentration of circulating lipids after fat intake and is an independent risk factor for cardiovascular disease. Exercise is known to reduce postprandial lipemia and its negative clinical outcomes. OBJECTIVE:This study investigated the effect of intense intermittent versus moderate continuous exercise using the same energy expenditure in postprandial lipemia.MATERIALS AND METHODS:Twenty healthy men (aged 21.5±3.5 years) performed a random sequence of either rest or 500 Kcal tests separated by a minimum 48 h interval as follows: (a) no exercise (control), (b) intense intermittent exercise, or (c) moderate continuous exercise. Each test series was completed 30 min before ingestion of a high-fat meal (1 g fat/kg). Venous blood was collected before and at 1, 2, 3 and 4 hours after the high-fat meal. Postprandial lipemia was assessed using the area under the curve approach as well as a kinetic profile of mean lipid variables. Statistical significance was tested at the p≤0.05 level.RESULTS:With both statistical approaches, intense intermittent and moderate continuous exercises were both effective in reducing postprandial triglycerides; however, only intense intermittent exercise reduced the levels of postprandial very low density lipoprotein. Intense intermittent and continuous exercise produced lower levels of insulinemia using the area under the curve analysis only.CONCLUSION:Intense intermittent or continuous exercise with an energy expenditure of 500 kcal completed 30 min before ingestion of high-fat meal reduced postprandial lipid levels to different levels in physically active men. Understanding these relevant differences will enable clinicians to provide the best exercise prescription for patients.

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“…Participants included community-dwelling elderly women participating in the ongoing program established by the Catholic University of Brasília, Brazil, and the geriatric service of its university hospital to promote preventive health actions for the elderly population [19,20] . Following inspection of medical records, patients were excluded if any of the following were present: noncontrolled type 2 diabetes, obesity, having smoked more than 100 cigarettes in their lifetime and/or having drunk at least one dose (12 g) of alcohol per week within the past 12 months.…”

Section: Participants and Methodsmentioning

confidence: 99%

Long-Term Resistance Training Is Associated with Reduced Circulating Levels of IL-6, IFN-Gamma and TNF-Alpha in Elderly Women

Córdova

Lopes-e-Silva

Pires

et al. 2011

Neuroimmunomodulation

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Objective: The increase in inflammatory activity associated with aging is a characteristic of chronic disease processes that accounts for most of the mortality in the elderly. Resistance training (RT) has been shown to promote metabolic and functional benefits in this population. The objective of this study was to investigate the association between long-term RT and circulating levels of the proinflammatory mediators IL-6, TNF-α and IFN-γ in elderly women. Methods: This cross-sectional study included 54 older outpatients divided into a group that underwent RT (n = 28) for an average of 8.6 ± 0.3 months and a sedentary group (n = 26). Measurements were taken only at the end of the intervention, and cytokine values were log-transformed. Dietary intake was controlled as a confounding factor. Results: The RT group presented reduced levels of log₁₀IFN-γ (approx. 45%; p = 0.003), log₁₀IL-6 (approx. 30%; p = 0.002) and log₁₀TNF-α (approx. 22%; p = 0.036). Total caloric intake and systolic arterial blood pressure were significantly lower in the RT group (p = 0.001 and p = 0.022, respectively). Pearson’s product moment correlation test revealed a negative association between the fat-free mass (FFM) index and log-transformed IL-6 levels (p = 0.03; n = 54) and a trend towards significance for the correlation between the FFM index and log₁₀IFN-γ (p = 0.05; n = 54). Conclusion: Long-term, moderate-intensity RT in elderly women is associated with lower circulating levels of cytokines that are potentially implicated in disorders associated with physical inactivity and aging.

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Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women

Cited by 18 publications

References 43 publications

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia

The influence of intense intermittent versus moderate continuous exercise on postprandial lipemia

Long-Term Resistance Training Is Associated with Reduced Circulating Levels of IL-6, IFN-Gamma and TNF-Alpha in Elderly Women

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