Dietary fatty acid composition affects food intake and gut–brain satiety signaling in Senegalese sole (Solea senegalensis, Kaup 1858) larvae and post-larvae

Bonačić, Kruno; Campoverde, Cindy; Gómez-Arbonés, Javier; Gisbert, Enric; Estévez, Alicia; Morais, Sofía

doi:10.1016/j.ygcen.2016.02.002

Cited by 30 publications

(23 citation statements)

References 107 publications

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“…This occurred for instance in rainbow trout (Peragón et al, 2000; Rasmussen et al, 2000; Gélineau et al, 2001; Forsman and Ruohonen, 2009; Figueiredo-Silva et al, 2012c; Saravanan et al, 2013), chinook salmon (Silverstein et al, 1999), polka-dot grouper (Williams et al, 2006), Senegalese sole (Bonacic et al, 2016) or grass carp (Li et al, 2016). Moreover, enhanced lipid storage is also usually associated with a reduced food intake (Shearer et al, 1997; Silverstein et al, 1999; Johansen et al, 2002, 2003).…”

Section: Impact Of Nutrient Sensing On Food Intake Regulationmentioning

confidence: 99%

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

2017

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Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fish species), and intestine] locations whereas fatty acid sensors seem to be present in hypothalamus, liver and BB. Glucose and fatty acid sensing capacities relate to food intake regulation and metabolism in fish. Hypothalamus is as a signaling integratory center in a way that detection of increased levels of nutrients result in food intake inhibition through changes in the expression of anorexigenic and orexigenic neuropeptides. Moreover, central nutrient sensing modulates functions in the periphery since they elicit changes in hepatic metabolism as well as in hormone secretion to counter-regulate changes in nutrient levels detected in the CNS. At peripheral level, the direct nutrient detection in liver has a crucial role in homeostatic control of glucose and fatty acid whereas in BB and intestine nutrient sensing is probably involved in regulation of hormone secretion from endocrine cells.

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Section: Impact Of Nutrient Sensing On Food Intake Regulationmentioning

confidence: 99%

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

2017

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“…treatment with EPA did not result in relevant changes in the expression of these peptides (only of cart2b; Conde-Sieira et al, 2015). In a previous experiment, we analysed changes in gene expression of peripheral peptides and neuropeptides in Senegalese sole larvae and post-larvae after feeding with Artemia enriched with different oils, especially rich in the same FAs that were administered in the present study (Bonacic et al, 2016). However, it is difficult to correlate the results of the two experiments given that we previously Fig.…”

Section: All Four Assessed Fas Appear To Have the Potential To Enhancmentioning

confidence: 66%

“…In fact, FA-sensing systems did not appear to be activated in the present study (see below), supporting this hypothesis. In the case of cart1b, its expression was not affected 3 h after feeding with any FA treatment but was significantly reduced 6 h after administration of ALA, but not in any of the remaining treatments, including EPA (as might have been expected from Bonacic et al, 2016). The reasons for this response are elusive at the moment, but do not seem to be related to FA sensing.…”

Section: All Four Assessed Fas Appear To Have the Potential To Enhancmentioning

confidence: 88%

“…As far as we know, there are no available studies assessing the impact of specific nutrients on the regulation of food intake in fish larvae and post-larvae. In a preliminary study with Senegalese sole larvae (Bonacic et al, 2016), we observed differences in the intake of Artemia prey that had been enriched with different oils (olive, soybean, linseed and cod liver oil); specifically, there was a higher ingestion of prey enriched with cod liver oil. However, the expression of neuropeptides in whole larvae could not explain such differences, even though larvae on the cod liver oil-enriched Artemia diet had the most dissimilar gene expression pattern of the four dietary groups.…”

Section: Introductionmentioning

confidence: 91%

“…In teleosts, its roles have not been well documented but the retention of several duplicated genes (in sole, up to seven homologues have been reported) suggests the conservation of multiple functions, or even the development of new ones . In this respect, Bonacic et al (2016) reported the transcriptional regulation of cart1b, which did not show a response to the ingestion of food in the brain of sole juveniles , but was affected by the FA composition of the diet in a manner consistent with an anorexigenic role (expression reduced in larvae fed the cod liver oil, EPA-rich diet). Similarly, cart1a and cart1b seemed to respond to the FA composition (lipid source) of the diet, correlating with food intake in juvenile sole (Bonacic et al, 2017).…”

Section: All Four Assessed Fas Appear To Have the Potential To Enhancmentioning

confidence: 99%

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Orally administrated fatty acids enhanced anorectic potential but did not activate central fatty acid sensing in Senegalese sole post-larvae

Velasco

Bonačić

Soengas

et al. 2016

Journal of Experimental Biology

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Studies in fish have reported the presence and function of fatty acid (FA)-sensing systems comparable in many aspects to those known in mammals. Such studies were carried out in juvenile and adult fish, but the presence of FA-sensing systems and control of food intake have never been evaluated in early life stages, despite the importance of establishing when appetite regulation becomes functional in larval fish. In this study, we aimed to elucidate the possible effects of different specific FAs on neural FA-sensing systems and neuropeptides involved in the control of food intake in Senegalese sole post-larvae. To achieve this, we orally administered post-larvae with different solutions containing pure FA -oleate (OA), linoleate (LA), α-linolenate (ALA) or eicosapentaenoate (EPA) -and evaluated changes in mRNA abundance of neuropeptides involved in the control of food intake and of transcripts related to putative FA-sensing systems, 3 and 6 h post-administration. The changes in neuropeptide gene expression were relatively consistent with the activation of anorectic pathways (enhanced cart4 and pomcb) and a decrease in orexigenic factors (npy) following intake of FA. Even though there were a few differences depending on the nature of the FA, the observed changes appear to suggest the existence of a putative anorectic response in post-larvae fish to the ingestion of all four tested FAs. However, changes in neuropeptides cannot be explained by the integration of metabolic information regarding FAs in circulation through FA-sensing mechanisms in the brain. Only the reduction in mRNA levels of the FA metabolism gene acc in OA-treated (6 h), ALA-treated (3 h) and EPA-treated (3 and 6 h) post-larvae could be indicative of the presence of a FA-sensing system, but most genes either were not significantly regulated ( fat/cd36-lmp2, acly, kir6.x, srebp1c) or were affected in a way that was inconsistent with FAsensing mechanisms ( fat/cd36-pg4l, fas, cpt1.1, cpt1.2, cpt1.3, sur, pparα and lxrα).

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Variability in Digestive Enzyme Capacity in Early Stages of Marine Fish Larvae: Ontogenetic Variations, Biorhythms, Hormonal Control and Nutrient Sensing Mechanisms

Ueberschär¹,

Navarro-Guillén

Gomes

et al. 2018

Emerging Issues in Fish Larvae Research

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Dietary fatty acid composition affects food intake and gut–brain satiety signaling in Senegalese sole (Solea senegalensis, Kaup 1858) larvae and post-larvae

Cited by 30 publications

References 107 publications

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

Orally administrated fatty acids enhanced anorectic potential but did not activate central fatty acid sensing in Senegalese sole post-larvae

Variability in Digestive Enzyme Capacity in Early Stages of Marine Fish Larvae: Ontogenetic Variations, Biorhythms, Hormonal Control and Nutrient Sensing Mechanisms

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