Dietary GABA enhances hypoxia tolerance of a bottom-dwelling carp, Cirrhinus mrigala by modulating HIF-1α, thyroid hormones and metabolic responses

Varghese, Tincy; Kumar, Vijay; Anand, Garima; Dasgupta, Subrata; Pal, A. K.

doi:10.1007/s10695-019-00708-4

Cited by 15 publications

(6 citation statements)

References 50 publications

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“…In 2013, Lardon et al used 1H-NMR to measure substances produced by carp brains treated with hypoxia, and after 24 h, the glutamate level of common carp in hypoxia was lower than in normoxia [ 67 ]. GABA was demonstrated to increase HIF1A and thyroid levels to further regulate metabolism in Cirrhinus mrigala under hypoxic conditions [ 68 ]. The interaction between cortisol and the thyroid was also shown to regulate ion transport and achieve the regulation of Na + /K + -ATPase [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Hung

Chen

Hsu

et al. 2022

Genes

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The common carp is a hypoxia-tolerant fish, and the understanding of its ability to live in low-oxygen environments has been applied to human health issues such as cancer and neuron degeneration. Here, we investigated differential gene expression changes during hypoxia in five common carp organs including the brain, the gill, the head kidney, the liver, and the intestine. Based on RNA sequencing, gene expression changes under hypoxic conditions were detected in over 1800 genes in common carp. The analysis of these genes further revealed that all five organs had high expression-specific properties. According to the results of the GO and KEGG, the pathways involved in the adaptation to hypoxia provided information on responses specific to each organ in low oxygen, such as glucose metabolism and energy usage, cholesterol synthesis, cell cycle, circadian rhythm, and dopamine activation. DisGeNET analysis showed that some human diseases such as cancer, diabetes, epilepsy, metabolism diseases, and social ability disorders were related to hypoxia-regulated genes. Our results suggested that common carp undergo various gene regulations in different organs under hypoxic conditions, and integrative bioinformatics may provide some potential targets for advancing disease research.

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Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Hung

Chen

Hsu

et al. 2022

Genes

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“…This bioactive compound is further involved in the regulation of heart rate and hormone secretion and has even been used to improve memory [ 282 , 283 , 284 , 285 ]. There is scientific evidence of GABA’s effect on regulating thyroid hormones and improving thyroid function, with implications for regulating obesity [ 286 , 287 , 288 , 289 , 290 ]. However, the best documented effect of GABA is the regulation of blood pressure by acting as an antihypertensive agent [ 291 ].…”

Section: Probiotic Potential Of Labmentioning

confidence: 99%

Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions

Coelho

Malcata

Silva

2022

Foods

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Traditional cheeses produced from raw milk exhibit a complex microbiota, characterized by a sequence of different microorganisms from milk coagulation and throughout maturation. Lactic acid bacteria (LAB) play an essential role in traditional cheese making, either as starter cultures that cause the rapid acidification of milk or as secondary microbiota that play an important role during cheese ripening. The enzymes produced by such dynamic LAB communities in raw milk are crucial, since they support proteolysis and lipolysis as chief drivers of flavor and texture of cheese. Recently, several LAB species have been characterized and used as probiotics that successfully promote human health. This review highlights the latest trends encompassing LAB acting in traditional raw milk cheeses (from cow, sheep, and goat milk), and their potential as probiotics and producers of bioactive compounds with health-promoting effects.

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“…Stress mitigation through dietary interventions is an emerging area of research in aquaculture. [226][227][228] Several dietary additives can attenuate the detrimental effects of ambient ammonia stress in fish. These additives include herbal extracts, phytochemicals, chemicals or microbial derivatives, as described in the Table 3.…”

Section: Mitigation Of Ammonia Toxicity Through Dietary Interventionsmentioning

confidence: 99%

“…Stress mitigation through dietary interventions is an emerging area of research in aquaculture 226–228 . Several dietary additives can attenuate the detrimental effects of ambient ammonia stress in fish.…”

Section: Mitigation Of Ammonia Toxicity Through Dietary Interventionsmentioning

confidence: 99%

Ammonia induced toxico‐physiological responses in fish and management interventions

Parvathy

Das

Jifiriya

et al. 2022

Reviews in Aquaculture

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Intensification of aquaculture practices resulted in increased ammonia production in the culture systems. Lack of proper management of the culture system will result in elevated ammonia, which adversely affects the culture species. Moreover, with the ongoing global warming, fish metabolism and ammonia excretion are expected to increase. This, coupled with the hypoxic condition, exacerbates the severity of ammonia toxicity. Ammonia toxicity can alter the growth and the biochemical, physiological and immunological responses of fish. Several factors such as pH, temperature, salinity, dissolved oxygen, species and life stages of fish, physical activity, feeding and stress influence the toxicity of ammonia in fish. A proper understanding of these factors is a prerequisite for successful aquaculture. The physiological changes caused by the elevated ammonia hinder homeostasis that eventually increases their susceptibility to diseases. This review discusses ammonia toxicity in fish, factors affecting the toxicity and various physiological, haematological, histological and immunological responses induced by the elevated ammonia. Furthermore, the review summarizes various management and dietary interventions to mitigate ammonia and ammonia induced stress in aquaculture.

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Dietary GABA enhances hypoxia tolerance of a bottom-dwelling carp, Cirrhinus mrigala by modulating HIF-1α, thyroid hormones and metabolic responses

Cited by 15 publications

References 50 publications

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions

Ammonia induced toxico‐physiological responses in fish and management interventions

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