Dietary‐Induced Hyperparathyroidism Affects Serum and Gingival Proinflammatory Cytokine Levels in Rats

Lütfioğlu, Müge; Sakallıoğlu, Umur; Sakallıoğlu, Elif Eser; Diraman, Emine; Çiftçi, Gülay; Tutkun, Ferda

doi:10.1902/jop.2009.090353

Cited by 13 publications

(14 citation statements)

References 54 publications

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“…Adipose tissue from patients with primary hyperparathyroidism showed upregulation of inflammatory genes [31]. Dietary-induced hyperparathyroidism in rodents led to increased serum proinflammatory cytokine production [32]. Furthermore, in obese adolescents, PTH levels were closely correlated with CRP levels and triglycerides: high-density lipoprotein ratio [33].…”

Section: Discussionmentioning

confidence: 99%

Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults

Cheng

Liu

et al. 2014

Mediators of Inflammation

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Background and Aims. High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality. Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results. This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults. Materials and Methods. Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression. Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression. Results. CRP, RDW, and PLR values increased with increasing serum PTH concentration. After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P < 0.001), while PLR marginally increased (P = 0.190 and P = 0.095 using PTH as a categorical and continuous variable, resp.). The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously. Conclusion. These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population. The casual relationship between PTH levels and inflammation remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults

Cheng

Liu

et al. 2014

Mediators of Inflammation

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“…IL‐1β and TNF‐α) both in serum and gingiva (Lütfioğlu et al. ). This finding may facilitate to propose some possible effects of dHPT on healthy and diseased periodontia, as it is in agreement with some previous investigations that have similarly documented proinflammatory cytokine increase in serum and bone due to primary and/or secondary HPT (Grey et al.…”

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confidence: 99%

The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats

Lütfioğlu

Sakallıoğlu²,

Sakallıoğlu³

et al. 2011

J Clinic Periodontology

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“…Therefore, determination of local cytokine levels compared to systemic levels in terms of measuring the condition of local inflammation can provide results that were more reliable. To obtain homogenate from gingival biopsy specimens taken from the ligature-placed teeth is an appropriate method for the determination of local cytokine levels (30).…”

Section: Discussionmentioning

confidence: 99%

The histopathological and morphometric investigation of the effects of systemically administered humic acid on alveolar bone loss in ligature‐induced periodontitis in rats

Çalışır

Akpınar

Poyraz

et al. 2015

J of Periodontal Research

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Dietary‐Induced Hyperparathyroidism Affects Serum and Gingival Proinflammatory Cytokine Levels in Rats

Abstract: The results suggested that increased serum proinflammatory cytokine production may be a complication of dHPT, and this may affect healthy and diseased periodontia by increasing gingival proinflammatory cytokine levels.

Cited by 13 publications

References 54 publications

Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults

Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults

The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats

The histopathological and morphometric investigation of the effects of systemically administered humic acid on alveolar bone loss in ligature‐induced periodontitis in rats

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