Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

Abstract

Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40–65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.

Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People

“…Only one study in Spain has utilized the DII technique to investigate the association between DII and S-Klotho plasma levels. Interestingly, Lucas et al's results ( 2 ), based on a survey sample of sedentary middle-aged adults, were just the opposite of ours. Our results support a negative correlation between higher DII scores and higher S-Klotho levels in middle-aged and elderly Americans, which is reasonable and consistent with the hypothetical effect of DII.…”

“…The hydrolysis of protein on the Klotho membrane produces the exfoliated form (S-Klotho) of Klotho protein. In comparison to membrane Klotho protein, S-Klotho protein is more prevalent in the human body, with S-Klotho found in urine, blood, and cerebrospinal fluid (CSF) ( 2 – 4 ). As a humoral factor, it performs a variety of biological functions in the circulatory system, including inflammation regulation, antioxidation, and senescence prevention ( 5 , 6 ).…”

“…DII has been adopted for studies to better know the relationship between DII and disease. However, as far as we know, the relationship between the Mediterranean diet and S-Klotho has been studied, and there is only one article on DII and S-Klotho in middle-aged people, and the sample size is small ( n = 73) ( 2 ), so it seems to be very important to find out whether the pro-inflammatory diet can regulate the plasma level of S-Klotho in humans. The goal of this study is to explore the connection between DII and S-Klotho in middle-aged and elderly adults using data from the National Health and Nutrition Examination Survey (NHANES 2007–2016).…”

Klotho, Aging, and the Failing Kidney

“…Specifically, Hsu et al suggest that this can be achieved with resveratrol administration in vitro (NRK-52E cells) and in vivo (mouse kidney) with involvement of the ATF3/c-Jun pathway (189). However, subsequent analysis in the FIT-AGEING cohort was only able to show a weak association between the Dietary Inflammatory Index (DII) (190) or adherence to the Mediterranean Diet (191) with soluble Klotho. These associations disappeared when corrected for Lean Mass Index.…”

Klotho and Abdominal Aortic Calcifification: Results from NHANES 2013-2014

“…There are two forms of Klotho protein in vivo: membrane type and secretory type. Compared with membrane Klotho protein, secretory Klotho protein plays a dominant role in human body, and secretory Klotho protein (S-Klotho) can be detected in blood, urine and cerebrospinal uid [2][3][4]. As a humoral factor in the circulatory system, it performs a variety of biological functions, such as inhibition of in ammation, antioxidation, inhibition of apoptosis and senescence [5,6].…”