Dietary Influence on Pancreatic Cancer Growth by Catechin and Inositol Hexaphosphate

McMillan, Brian; Riggs, Dale R.; Jackson, Barbara; Cunningham, Cynthia; McFadden, David W.

doi:10.1016/j.jss.2007.03.065

Cited by 28 publications

(12 citation statements)

References 12 publications

(17 reference statements)

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“…Catechin has also been joined with inositol hexaphosphate (a carbohydrate) against pancreatic cancer cell lines. This conjugate increased apoptosis and inhibited cell growth in a greater manner that the isolated compounds [182]. Vittorio et al [183] used dextran, a branched glucan in conjunction with catechin against pancreatic ductal adenocarcinoma.…”

Section: Flavanolsmentioning

confidence: 99%

The Role of Phenolic Compounds in the Fight against Cancer – A Review

Carocho¹,

Ferreira

2013

ACAMC

237

144

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Abstract:Cancer is a worldwide scourge; it's the leading cause of death in developed countries and is increasing in developing countries. Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of the disease and its consequent mortality. For many years, phenolic compounds have been intensely studied for their antitumor, proapoptotic and antiangiogenic effects. In recent years, the usage of these compounds has increased considerably.This manuscript intends to structurally characterize the different phenolic compounds (flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins and lignans) and their metabolic pathways as well as review the most important results regarding these compounds and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials.

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Section: Flavanolsmentioning

confidence: 99%

The Role of Phenolic Compounds in the Fight against Cancer – A Review

Carocho¹,

Ferreira

2013

ACAMC

237

144

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show abstract

“…Specifically in pancreatic cancer, it has been reported to induce apoptosis, both in vitro and in vivo , through the activation of caspase‐3, the upregulation of pro‐apoptotic Bax, Bak, Bcl‐X S , and PUMA, and the downregulation of antiapoptotic Bcl‐2 and Bcl‐X L 52–54. Catechin, another green tea flavanol, has also been shown to have anticarcinogenic effects on pancreatic cancer by inducing early apoptosis 55.…”

Section: Pancreatic Cancer and Bioactive Foods Componentsmentioning

confidence: 99%

Dietary factors and pancreatic cancer: The role of food bioactive compounds

Johnson

Mejía

2010

Molecular Nutrition Food Res

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Pancreatic cancer is the fourth leading cause of cancer mortality among both men and women in the United States with a 5-year survival rate of only 4%. Several dietary factors may influence the risk of developing pancreatic cancer and its recurrence. Some of these factors may offer innovative therapies for prevention of this disease. The goal of this review is to provide an overview of pancreatic cancer, as well as current knowledge on the epidemiological, in vitro, in vivo, and clinical studies conducted about this disease using various dietary agents. The main focus is on food-based approaches for preventing this disease particularly, citrus fruits, and foods containing flavonoids, curcumin, folate and vitamin D.

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“…cyclooxygenase-2, cyclin D1 and c-Myc), and invasive and metastatic genes (e.g. matrix metalloproteinases, intracellular adhesion molecule-1, and angiogenic protein vascular endothelial growth factor) (Table 2) (51–130). This article shows that “adding spice to your life” has the potential to not only improve the flavor of your favorite dishes, but to help fight the various stages of tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

Aggarwal

Kuiken

Iyer

et al. 2009

Exp Biol Med (Maywood)

179

149

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Despite the fact cancer is primarily a preventable disease, recent statistics indicate cancer will become the number one killer worldwide in 2010. Since certain cancers are more prevalent in the people of some countries than others, suggests the role of lifestyle. For instance cancer incidence among people from the Indian subcontinent, where most spices are consumed, is much lower than that in the Western World. Spices have been consumed for centuries for a variety of purposes—as flavoring agents, colorants, and preservatives. However, there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases, so spices are now emerging as more than just flavor aids, but as agents that can not only prevent but may even treat disease. In this article, we discuss the role of 41 common dietary spices with over 182 spice-derived nutraceuticals for their effects against different stages of tumorigenesis. Besides suppressing inflammatory pathways, spice-derived nutraceuticals can suppress survival, proliferation, invasion, and angiogenesis of tumor cells. We discuss how spice-derived nutraceuticals mediate such diverse effects and what their molecular targets are. Overall our review suggests “adding spice to your life” may serve as a healthy and delicious way to ward off cancer and other chronic diseases.

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Dietary Influence on Pancreatic Cancer Growth by Catechin and Inositol Hexaphosphate

Cited by 28 publications

References 12 publications

The Role of Phenolic Compounds in the Fight against Cancer – A Review

The Role of Phenolic Compounds in the Fight against Cancer – A Review

Dietary factors and pancreatic cancer: The role of food bioactive compounds

Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

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