Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort

Bo, Simona; Durazzo, Marilena; Guidi, Sabrina; Carello, Monica; Sacerdote, Carlotta; Silli, Barbara; Rosato, Rosalba; Cassader, Maurizio; Gentile, Luigi; Pagano, Gianfranco

doi:10.1093/ajcn/84.5.1062

Cited by 124 publications

(101 citation statements)

References 51 publications

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“…In large cohort studies, high fibre intakes have consistently been associated with a reduction in coronary heart disease risk (Pereira et al, 2004;Flight and Clifton, 2006). Cross-sectional (King et al, 2003;Ajani et al, 2004;King, 2005;Bo et al, 2006) and longitudinal (Ma et al, 2006) studies indicate an inverse association between dietary fibre (DF) intake and levels of inflammatory markers. In the prospective study by Ma et al (2006), multiple dietary and CRP measurements were taken and an inverse association between DF intake in both crosssectional and longitudinal analyses was found.…”

Section: Introductionmentioning

confidence: 99%

The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease

2009

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Background: C-reactive protein (CRP), a sensitive marker of inflammation, is an independent predictor of future cardiovascular disease (CVD), which is a major cause of death worldwide. In epidemiological trials, high-fibre intakes have consistently been associated with reduction in CVD risk and CRP levels. Objective: The objective of this study was to assess the influence of dietary fibre (DF) on CRP in clinical trials. Data sources: Databases were searched from the earliest record to April 2008 and supplemented by crosschecking reference lists of relevant publications. Study selection: Human adult intervention trials, at least 2 weeks in duration, with an increased and measurable consumption of DF were included and rated for quality. Data synthesis: Seven clinical trials were included, and six of these reported significantly lower CRP concentrations of 25-54% with increased DF consumption with dosages ranging between 3.3-7.8 g/MJ. The seventh trial with psyllium fibre supplementation failed to lower CRP levels significantly in overweight/obese individuals. Weight loss and altered fatty acid intakes were present in most of the studies. Conclusions: In the presence of weight loss and modified saturated, monounsaturated and polyunsaturated fat intakes, significantly lower CRP concentrations (k25-54%) are seen with increased fibre consumption (X3.3 g/MJ). Mechanisms are inconclusive but may involve the effect of DF on weight loss, and/or changes in the secretion, turnover or metabolism of insulin, glucose, adiponectin, interleukin-6, free fatty acids and triglycerides. Clinical studies of high-and low-fibre diets are needed to explore the potential favourable effects as observed epidemiologically, and to understand individual susceptibility to its antiinflammatory effect and long-term cardiovascular reduction.

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Section: Introductionmentioning

confidence: 99%

The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease

2009

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“…Five studies included both men and women, and two studies consisted women only. Five studies used semi-quantitative food frequency questionnaires to collect dietary data, while other two studies used secondary dietary data from NHANES (1999-2000 and 1999-2002).In the original studies, dietary Mg intake was either categorized into three / four groups based on RDA levels (10,18) or divided into tertiles or quintiles (4,(13)(14)(15)17). Serum CRP was measured by using high sensitivity assay techniques (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…A random effects meta-regression(16) was used to assess the overall linear relation between Mg intake and geometric mean levels of CRP with inverse variance as weights for each study. We also extracted ORs with 95% confidence intervals (CIs)in three cross-sectional studies (10,17,18). Natural logarithms transformed ORs and 95% CIs were used to compute the corresponding SEs.…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

Dibaba

Xun

2015

Eur J Clin Nutr

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Objectives-To quantitatively summarize the association of dietary magnesium (Mg) intake with serum C-reactive protein (CRP) levels in the general population.Methods-Observational and experimental studies through February 2013 were reviewed in PubMed and EMBASE. Additional information was retrieved through Google or hand search of related reference lists. The main outcome is either adjusted geometric mean of CRP or odds ratio (OR) of having serum CRP≥3 mg/L. Meta-regression was used to determine the linear association of dietary Mg intake and adjusted geometric means of CRP levels. A fixed-effects model was used to pool ORs of interest, comparing those in the lowest with those in the highest group of dietary Mg intake.Results-A dataset derived from seven cross-sectional studies including 32,918 participants was quantitatively assessed. A weighted inverse association between Mg intake and serum CRP levels was observed[β coefficient: −0.0028; 95% CI, −0.0043 to −0.0013; P for trend=0.001] from four cross-sectional studies. The pooled OR (95%CI) of having CRP≥3 mg/L was 1.49(1.18 to 1.89) comparing the lowest to the highest group of Mg intake from three studies with data available. Qualitative assessment among five intervention studies also showed a potential beneficial effect of Mg intake on serum CRP levels.Conclusion-This meta-analysis and systematic review indicate that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.

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“…Several studies have assessed relation of dietary magnesium with inflammatory markers [39][40][41][42][43][44] . In this study, higher inflammatory markers were observed among patients with magnesium intake lower than RDA.…”

Section: Discussionmentioning

confidence: 99%

Relation of magnesium with insulin resistance and inflammatory markers in subjects with known Coronary artery disease

Mahalle¹,

Mk²,

Kulkarni³

et al. 2014

J Cardiovasc. Dis. Res.

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INTRODUCTIONMagnesium is the second most abundant intracellular cation and is an essential element that has numerous biological functions. Magnesium is plentiful in green leafy, cereal, grain, nuts and legumes, however, refining or processing of food may deplete magnesium content by nearly 85% 1 . About 30% of ingested magnesium is absorbed by distal small intestine. Magnesium acts as a cofactor in many of enzymatic reactions in the human body. Magnesium is essential for the synthesis of nucleic acids and proteins, for intermediary metabolism particularly related to the neuromuscular and cardiovascular systems. Over 300 enzymes are dependent on magnesium. Magnesium influences the enzymatic activity by binding to legends such as ATP in ATP-requiring enzymes, enolase, pyruvate kinase, and pyrophosphatase, leading to conformational change during ABSTRACT Background: Magnesium plays an important role in regulating insulin action and secretion. Dietary magnesium deficiency and hypomagnesemia have been associated with inflammation. There is paucity of data regarding this in Indian subjects. Hence, we studied the relation of serum and dietary magnesium with insulin resistance (IR) and inflammatory markers. Methods & Results:We studied the relation of serum high sensitive C-Reactive Protein (hsCRP), interlukin-6 (IL-6) and tumor Necrosis Factor (TNF-α) with cardiovascular risk factors in three hundred coronary artery disease patients. Nutrition assessment was done at the time of recruitment. Patients were evaluated for anthropometry, cardiovascular risk factors, and blood samples were collected. Patients were divided into three groups according to serum magnesium levels; ≤1.6 (Group 1), >1.6-2.6 (Group 2) and: >2.6 mg/dl (Group 3) and into two groups according to recommended dietary allowance (RDA) for magnesium (≤350 mg/day and >350 mg/day). More than half of patients (58.6%) were having hypomagnesemia and 62% were consuming magnesium below RDA. Insulin and IR was significantly higher and insulin sensitivity was significantly lower in group 1 compared to group 2 and 3. Insulin and IR was correlated negatively; and insulin sensitivity was correlated positively with serum magnesium. Similarly inflammatory markers were significantly higher in group1 when compared with group 2 and 3 and they were correlated negatively with serum magnesium. Dietary magnesium was positively correlated with serum magnesium. Insulin and IR were significantly higher and insulin sensitivity was significantly lower in subjects with low RDA for magnesium. Insulin and IR were correlated negatively and sensitivity was correlated positively with dietary magnesium. Inflammatory markers; IL-6, TNF-α, and hs CRP were significantly high in subjects with low RDA for magnesium and were correlated negatively with dietary magnesium. Conclusion: Hypomagnesemia and low dietary magnesium is associated with IR and inflammatory markers in patients with coronary artery disease.

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Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort

Abstract: Reduced fiber intake was significantly associated with metabolic abnormalities; the magnesium effect might be confounded by fiber being in foods that also provided magnesium. Lower magnesium and fiber intakes were linked to hs-CRP >/= 3 mg/L in both the entire cohort and healthy persons.

Cited by 124 publications

References 51 publications

The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease

The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review

Relation of magnesium with insulin resistance and inflammatory markers in subjects with known Coronary artery disease

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