Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001–2004

Liu, Rui-Ji; Li, Shuying; Zhang, Xu; Yu, Junjie; Mao, Weipu; Sun, Chao; Xu, Bin; Chen, Ming

doi:10.3389/fnut.2022.974443

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…In a cross-sectional study involving 134 ED patients and 50 healthy controls, Jiangnan reported a greater prevalence of low blood levels of folic acid and vitamin B12 among ED patients than among control individuals 49 . Similarly, Liu's study of 3745 adult males in the U.S. revealed a link between ED risk and the intake of antioxidants such as magnesium, zinc, copper, and selenium 50 . However, these studies did not fully consider the influence of prooxidants or the synergistic effects of antioxidants within biological systems 51 .…”

Section: Discussionmentioning

confidence: 94%

The relationship between oxidative balance score and erectile dysfunction in the U.S. male adult population

Chen,

Zhang,

Zhou

et al. 2024

Sci Rep

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Oxidative stress strongly influences the pathophysiology of erectile dysfunction (ED). In this study, we used the oxidative balance score (OBS), a composite index, to measure the effects of oxidative stress triggered by diet and lifestyle factors. Here, we conducted a cross-sectional study to determine the statistical relationship between OBS and ED among adult males in the U.S. The data from 3318 participants in the National Health and Nutrition Examination Survey (NHANES) 2001–2004 were analyzed. Weighted logistic regression was used to correct for confounding factors and acquire nationwide representative estimates. Generalized additive modeling was used to explore the nonlinear relationship. We also supplemented subgroup and sensitivity analysis to examine the robustness of the main results. Multivariate logistic regression indicated a consistent negative linear association between OBS and ED across all participants [OR (95% CI) = 0.96 (0.94, 0.98)]. After categorizing OBS into tertiles, participants in the highest tertile had 43% lower odds of having ED than those in the lowest tertile [OR (95% CI) = 0.57 (0.37, 0.87)]. The generalized additive model also visualized the linear trend of this association. Furthermore, this linear relationship remained relatively consistent, regardless of whether subgroup or sensitivity analyses were performed. Our findings suggest that adopting a lifestyle and diet pattern that promotes favorable OBS may effectively protect against the development of ED, regardless of the underlying causes.

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Section: Discussionmentioning

confidence: 94%

The relationship between oxidative balance score and erectile dysfunction in the U.S. male adult population

Chen,

Zhang,

Zhou

et al. 2024

Sci Rep

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“…Trace metals actively participate in averting vascular damage and atherosclerosis through various pathways, thereby safeguarding the relatively narrow-diameter penile arteries. Existing studies (including multiple animal studies) propose that adhering to recommended dietary metal intake limits may prove advantageous in reducing the prevalence of erectile dysfunction, although research on the correlation between dietary metal intake and ED prevalence remains limited [4].…”

Section: Introductionmentioning

confidence: 99%

“…Cu actively participates in nitric oxide production, a compound that facilitates blood vessel relaxation and increased blood flow to the penis. Inadequate Cu levels may impede nitric oxide production, resulting in reduced blood flow and difficulties in achieving or maintaining an erection [4].…”

Section: Introductionmentioning

confidence: 99%

Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction

Rył,

Ciosek,

Szylińska

et al. 2024

Biomolecules

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Background: Erectile dysfunction (ED) stands out as one of the most prevalent sexual disorders in men, with its incidence progressively escalating with age. As delineated by the International Consultation Committee for Sexual Medicine on Definitions/Epidemiology/Risk Factors for Sexual Dysfunction, the prevalence of ED among men under 40 years is estimated to be within the range of 1–10%. The aim of this study was to determine the relationship between the concentration of bioelements (Zn, Cu, Fe, Cr, Mg, and Mn) in the serum and bone tissue and the concentration of selected hormones in men with and without erectile dysfunction. Materials and methods: The retrospective cohort study included 152 men who underwent total hip arthroplasty for hip osteoarthritis at the Department of Orthopaedic Traumatology and Musculoskeletal Oncology at the Pomeranian Medical University in Szczecin. Certain exclusion criteria were applied to ensure the integrity of the study. These included individuals with diabetes, a history of cancer, alcohol abuse, liver or kidney failure, New York Heart Association (NYHA) class III or IV heart failure, and those taking medications that affect bone metabolism, such as mineral supplements, neuroleptics, chemotherapeutic agents, immunosuppressants, corticosteroids, or antidepressants. Patients with hypogonadism or infertility were excluded from the study. Results: The study showed an association between bioT concentrations and Cu concentrations in both patients with and without erectile dysfunction. A correlation between bioactive testosterone and Cr concentrations was also observed in both groups. Patients with erectile dysfunction showed a relationship between bioT concentration and Zn concentration, TT concentration and Mn concentration, FT concentration and Zn concentration, and E2 concentration and Cr concentration. An analysis of elemental concentrations in bone tissue showed an association between FT and Mg and Mn concentrations, but only in patients with erectile dysfunction. In patients without erectile dysfunction, a correlation was observed between FT and Cu concentrations. A correlation was also observed between bioT concentrations and Mg, Mn, and Zn concentrations, but only in patients with erectile dysfunction. In patients without erectile dysfunction, a correlation was observed between bioT and Cu concentrations. Conclusions: Studying the relationship between the concentration of bioelements (Zn, Cu, Fe, Cr, Mg, and Mn) in the serum and bone tissue and the concentration of selected hormones in men may be important in explaining the etiology of the problem. The study of the concentration of Zn and Cu in bone tissue and serum showed that these two elements, regardless of the place of accumulation, may be related to the concentration of androgens in men.

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The Magnesium Connection: Impact on Erectile Dysfunction and Mortality

Chen,

Xie,

Liu

et al. 2024

Preprint

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This research examines both the cross-sectional and longitudinal relationships between magnesium depletion score (MDS) and erectile dysfunction (ED), as well as all-cause mortality in individuals diagnosed with ED. The analysis utilized data from the National Health and Nutrition Examination Survey (NHANES). To evaluate the correlation between MDS and ED, along with mortality outcomes, weighted multivariate regression and Cox proportional hazards models were employed. Out of the total 3,917 participants, 1,090 were identified as having ED, and 654 individuals succumbed to all-cause mortality. After controlling for potential confounding variables, it was found that each incremental increase of one point in MDS correlated with a 37% heightened risk of developing ED (OR: 1.37, 95% CI: 1.16–1.62). Furthermore, among those with ED, a greater MDS score was linked to a 30% elevation in the risk of all-cause mortality (HR: 1.30, 95% CI: 1.17–1.45). Sensitivity analyses, which included subgroup evaluations and propensity score matching (PSM), validated the robustness of these results. The findings indicate a significant association between MDS and both the prevalence of ED and the risk of all-cause mortality in individuals suffering from ED, highlighting the critical role of magnesium status in the health of men.

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Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001–2004

Cited by 3 publications

References 45 publications

The relationship between oxidative balance score and erectile dysfunction in the U.S. male adult population

The relationship between oxidative balance score and erectile dysfunction in the U.S. male adult population

Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction

The Magnesium Connection: Impact on Erectile Dysfunction and Mortality

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