Dietary micronutrients and cervical dysplasia in southwestern American Indian women

Di, Buckley; McPherson, R. Sue; Cq, North; Tm, Becker

doi:10.1080/01635589209514185

Cited by 41 publications

(13 citation statements)

References 15 publications

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“…Although case-control studies suggested an inverse association between vitamin E intake and invasive cervical cancer, 18,31,32 inconsistent results have been reported for noninvasive lesions. 30,[33][34][35][36][37] Two prospective studies suggest a protective effect of dietary beta-carotene 15,16 against HPV persistence, but results from case-control studies on ISC are inconsistent, 22,26,31,38 and a meta-analysis of RCT 7 did not observe a beneficial effect. Folate intake on ISC has been assessed in some case-control studies 26,39 and results were also inconsistent, and a meta-analysis of RCT 7 did not observe an effect.…”

Section: Discussionmentioning

confidence: 99%

Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

González

Travier

Luján-Barroso

et al. 2010

Intl Journal of Cancer

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Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow‐up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72–0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65–1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta‐carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.

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Section: Discussionmentioning

confidence: 99%

Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

González

Travier

Luján-Barroso

et al. 2010

Intl Journal of Cancer

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“…The findings of this study provide evidence that inadequate reserve of folate, as reflected in RBC folate contents may enhance the effect of tobacco smoking on OED risk. Furthermore, low level of folate was found to be related to an increased risk of epithelial dysplasia or carcinoma-in-situ [44,45]. These nutrients are likely to take the active role in the risk reduction effect.…”

Section: Discussionmentioning

confidence: 99%

Hematinic Deficiency and the risk of Oral Epithelial Dysplasia

Jaber¹

2017

Mouth Teeth

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Oral squamous cell carcinoma could be preceded by clinically evident oral potentially malignant disorders harboring oral epithelial dysplasia (OED. Hematinic deficiencies are associated with certain potentially malignant disorders and cancerous lesions. The aims of this study were: to evaluate the circulating levels of vitamin B 12 , folate status in patients with OED and to assess the impact tobacco smoking on these levels. To evaluate the circulating level of vitamin B 12 , serum folate, red blood cells folate among OED patients. Data were collected from 120 patients with OED and 120 healthy control Subjects matched for age and gender, selected from patients with oral diseases not caused by tobacco or alcohol or related to knowing hematinic deficiency. Most of patients with OED were current smokers of more than 20 cigarettes per day for more than 20 years compared with normal healthy control. A significant decrease in the serum levels of folate, red blood cell folate was found in OED compared to normal tobacco smokers (p<0.05). No significant differences in vitamin B 12 was found between OED cases and normal control subjects. These findings support the notion that OED may develop in persons who expose to tobacco smoking and have low folate level.

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“…Of note, a case-control study that assessed dietary intake of nutrients and vitamins among AI women living in the Southwest concluded that low intake of vitamin C, folate, and vitamin E increased the risk of cervical dysplasia. [22]…”

Section: Discussionmentioning

confidence: 99%

Risk factors for HPV infection among American Indian and white women in the Northern Plains

Bell

Schmidt-Grimminger

Jacobsen

et al. 2011

Gynecologic Oncology

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Objective American Indian (AI) women living in the Northern Plains have high incidence and mortality rates for cervical cancer. We assessed risk factors for human papillomavirus (HPV) infection among AI and White women. Methods We tested cervical samples for HPV infection obtained from women ages 18-65 years attending 2 rural AI reservation clinics in South Dakota (n = 235) and an urban clinic serving predominantly White women (n = 246). Patients self-reported information on HPV risk factors. We used percentages and chi-square tests to compare risk factors, and logistic regression with HPV status as the outcome to quantify the association between HPV and risk factors. Results AI women had more risk factors than White women, including younger age, less education, less vegetable consumption, more sexual partners, younger age at first sexual experience and first pregnancy, and more pregnancies (p values ≤ 0.003). AI women more often endorsed recreational drug use, history of sexually transmitted diseases, and current smoking; White women reported more alcohol consumption (p values < 0.001). In multivariate analysis, younger age and current smoking were associated with higher odds of HPV infection in AI women, whereas a higher number of sexual partners was associated with higher odds of HPV infection in White women. Conclusions AI women have a high burden of risk factors for HPV disease, and associations with HPV infection appear to differ by community. Knowledge of specific risk factors in AI populations may provide targets for public health officials to decrease HPV infection and disease.

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Dietary micronutrients and cervical dysplasia in southwestern American Indian women

Cited by 41 publications

References 15 publications

Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

Hematinic Deficiency and the risk of Oral Epithelial Dysplasia

Risk factors for HPV infection among American Indian and white women in the Northern Plains

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