Dietary polyherbal supplementation decreases CD3+ cell infiltration into pancreatic islets and prevents hyperglycemia in nonobese diabetic mice

Burke, Susan J.; Karlstad, Michael D.; Conley, Caroline P.; Reel, Danielle; Whelan, Jay; Collier, J. Jason

doi:10.1016/j.nutres.2014.12.003

Cited by 10 publications

(11 citation statements)

References 78 publications

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“…Our data pertaining to Zyflamend and several studies from other laboratories (Bemis et al, 2005;Burke et al, 2015;Capodice et al, 2009;Ekmekcioglu et al, 2011;Huang, Chen, et al, 2011;Huang et al, 2014;Kim et al, 2012;Kunnumakkara et al, 2012;Mohebati et al, 2012;Rafailov et al, 2007;Sandur et al, 2007;Yan et al, 2012;Yang et al, 2007Yang et al, , 2008 reveal diverse mechanisms of action, possibly explaining its robust effects using in vivo models of tumorigenesis at oral doses that mimic human intakes (Huang, Chen, et al, 2011;Kunnumakkara et al, 2012). Because herbal extracts are composed of multiple compounds, it is difficult to directly extrapolate a standard concentration.…”

Section: Fig 3 -Regulation Of Downstream Targets Of Ampk By Aicar Inmentioning

confidence: 85%

“…Its original formulation almost 2 decades ago was based on those herbs that had antioxidant and antiinflammatory properties. Its subsequent use in experimental investigations in an assortment of cancer models has drawn attention by a variety of laboratories interested in the role of natural products in health and disease (Bemis et al, 2005;Burke et al, 2015;Capodice et al, 2009;Ekmekcioglu et al, 2011;Huang, Chen, et al, 2011;Huang et al, 2014;Kim et al, 2012;Kunnumakkara et al, 2012;Mohebati et al, 2012;Rafailov et al, 2007;Sandur et al, 2007;Yan et al, 2012;Yang et al, 2007Yang et al, , 2008. There are always concerns regarding reproducibility and quality control of commercial products.…”

Section: Discussionmentioning

confidence: 99%

“…In our laboratory, we have been studying the effects of Zyflamend on preclinical models of chronic diseases, including cancer (Huang, Chen, et al, 2011;Huang et al, 2014) and diabetes (Burke et al, 2015), with an emphasis on castration-resistant prostate cancer (Huang, Chen, et al, 2011;Huang et al, 2014) using cell lines derived from the CWR22 lineage (Nagabhushan et al, 1996;Pretlow et al, 1993). We focus our attention on this lineage because the androgen dependent CWR22 cells can relapse into the androgen-insensitive CWR22R cell line in vivo following androgen deprivation (McEntee et al, 2008;Nagabhushan et al, 1996).…”

Section: Fig 3 -Regulation Of Downstream Targets Of Ampk By Aicar Inmentioning

confidence: 99%

“…Zyflamend® (New Chapter, Brattleboro, VT, USA) is a blend of 10 herbal extracts (ginger, rosemary, turmeric, Chinese goldthread, holy basil, hu zhang, barberry, oregano, green tea and baikal skullcap) formulated based on their antioxidant and potentially anti-inflammatory properties. To date, there have been 14 research articles investigating the anti-cancer effects of this blend, covering in vitro, preclinical and clinical studies involving the prostate, bone, skin, kidney, breast and pancreas (Bemis, Capodice, Anastasiadis, Katz, & Buttyan, 2005;Burke et al, 2015;Capodice et al, 2009;Ekmekcioglu et al, 2011;Huang, Chen, et al, 2011;Huang et al, 2014;Kim et al, 2012;Kunnumakkara et al, 2012;Mohebati et al, 2012;Rafailov, Cammack, Stone, & Katz, 2007;Sandur et al, 2007;Yan, Xie, Capodice, & Katz, 2012;Yang et al, 2007Yang et al, , 2008, with prostate being the predominant focus. It has been reported that a number of its constituents act synergistically such that physiological doses are possible (Zhao, Collier, Huang, & Whelan, 2014) and multiple mechanisms of action have been linked in a variety of cancer cell lines by down regulating the androgen receptor (Huang, Chen, et al, 2011;Huang et al, 2014;Yan et al, 2012), insulin-like growth factor-1R (Huang, Chen, et al, 2011;, class I and II HDACs (Huang, Chen, et al, 2011;Huang et al, 2014), COX-1 and COX-2 activities (Bemis et al, 2005;Ekmekcioglu et al, 2011;Kunnumakkara et al, 2012), 12-LOX and Rb protein phosphorylation (Yang et al, 2007), and the up regulation of tumour suppressor genes such as p21 and p27 (Bemis et al, 2005;Huang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that a number of its constituents act synergistically such that physiological doses are possible (Zhao, Collier, Huang, & Whelan, 2014) and multiple mechanisms of action have been linked in a variety of cancer cell lines by down regulating the androgen receptor (Huang, Chen, et al, 2011;Huang et al, 2014;Yan et al, 2012), insulin-like growth factor-1R (Huang, Chen, et al, 2011;, class I and II HDACs (Huang, Chen, et al, 2011;Huang et al, 2014), COX-1 and COX-2 activities (Bemis et al, 2005;Ekmekcioglu et al, 2011;Kunnumakkara et al, 2012), 12-LOX and Rb protein phosphorylation (Yang et al, 2007), and the up regulation of tumour suppressor genes such as p21 and p27 (Bemis et al, 2005;Huang et al, 2014). Zyflamend has also been shown to modulate NF-κB activation (Burke et al, 2015;Kunnumakkara et al, 2012;Sandur et al, 2007), iNOS (Ekmekcioglu et al, 2011), apoptotic pathways (Ekmekcioglu et al, 2011;Kim et al, 2012;Kunnumakkara et al, 2012), and aryl hydrocarbon receptor expression (Mohebati et al, 2012). It is believed that it is the combination of bioactives that accounts for modulation of multiple pathways at relatively low doses (as described in Huang, Chen, et al, 2011;Zhao et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK

Zhao

Donohoe

Huang

et al. 2015

Journal of Functional Foods

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Available online A B S T R A C TA select blend of herbal extracts, Zyflamend, inhibits tumour growth via multiple mechanisms that arise through synergistic interactions between individual components. The objective in this study was to determine if the antiproliferative effects are mediated, in part, through the activation of AMPK signalling and inhibition of its downstream targets, lipogenesis and mTORC1 complex. By increasing the phosphorylation of AMPK in CWR22Rv1 and PC3 prostate cancer cell lines, Zyflamend decreased de novo lipid biosynthesis by decreasing the activity of acetyl-CoA carboxylase and the expressions of fatty acid synthase and SREBP-1c, with a concomitant up regulation of fatty acid oxidation. In addition, via AMPK, Zyflamend inhibited the activity of mTORC1 complex by directly phosphorylating raptor. Treatment with AICAR (activator of AMPK), siRNA knockdown, pharmacological inhibition, and overexpression of AMPK were used to confirm the up regulation of AMPK by Zyflamend. These results suggest that Zyflamend inhibited tumour cell proliferation via up regulation of AMPK signalling.

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Section: Fig 3 -Regulation Of Downstream Targets Of Ampk By Aicar Inmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Fig 3 -Regulation Of Downstream Targets Of Ampk By Aicar Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK

Zhao

Donohoe

Huang

et al. 2015

Journal of Functional Foods

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Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy

Smoak

Burke

Collier

2021

SN Compr. Clin. Med.

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Diabetes mellitus is a major public health problem worldwide. This endocrine disease is clustered into distinct subtypes based on the route of development, with the most common forms associated with either autoimmunity (T1DM) or obesity (T2DM). A shared hallmark of both major forms of diabetes is a reduction in function (insulin secretion) or mass (cell number) of the pancreatic islet beta-cell. Diminutions in both mass and function are often present. A wide assortment of plants have been used historically to reduce the pathological features associated with diabetes. In this review, we provide an organized viewpoint focused around the phytochemicals and herbal extracts investigated using various preclinical and clinical study designs. In some cases, crude extracts were examined directly, and in others, purified compounds were explored for their possible therapeutic efficacy. A subset of these studies compared the botanical product with standard of care prescribed drugs. Finally, we note that botanical formulations are likely suspects for future drug discovery and refinement into class(es) of compounds that have either direct or adjuvant therapeutic benefit.

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Glycated whey proteins protect NOD mice against type 1 diabetes by increasing anti-inflammatory responses and decreasing autoreactivity to self-antigens

Chen

Nagy

Guo

2019

Journal of Functional Foods

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Our previous studies suggested that early glycation products (EGPs) generated in the first step of Maillard reaction/glycation were anti-inflammatory. The objectives of the present study were to determine the effects of EGPs derived from the whey protein isolate-glucose system on type 1 diabetes (T1D), and the underlying immunological mechanisms. In non-obese diabetic (NOD) mice, EGPs at the physiological dose of 600 mg/kg/day increased glucose metabolism, decreased non-fasting blood glucose levels and T1D incidence, decreased insulin resistance, and decreased the pancreatic immune infiltration. The protective effects were accompanied with decreases in CD4 − CD8 + thymocytes, CD8 + T cells and serum insulin autoantibody levels, and increases in splenic CD4 + CD25 + T cells, macrophage M2/M1 ratio and serum IL-10 level. However, similar treatment with EGPs produced minimal effect on the multiple low-dose streptozotocin-induced hyperglycemia. In conclusion, EGPs protected NOD mice against T1D via increasing antiinflammatory immune responses and decreasing autoreactivity to self-antigens.

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Dietary polyherbal supplementation decreases CD3+ cell infiltration into pancreatic islets and prevents hyperglycemia in nonobese diabetic mice

Cited by 10 publications

References 78 publications

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK

Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy

Glycated whey proteins protect NOD mice against type 1 diabetes by increasing anti-inflammatory responses and decreasing autoreactivity to self-antigens

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