Dietary Polyphenols Affect Muc5Ac Expression and Ciliary Movement in Respiratory Cells and Nasal Mucosa

Chang, Jung Hyun; Song, Kang Il; Kim, Hyun-Jun; Kim, Jeong Hong; Kim, Na Hyun; Kim, Kyung Soo

doi:10.2500/ajra.2010.24.3447

Cited by 27 publications

(16 citation statements)

References 21 publications

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“…40 We hypothesized that anthocyanidins may be potential natural topical therapeutics for CRS, either as T2R agonists or direct antimicrobials. Because plant compounds can have multiple effects on airway epithelial cells, 41 we sought to investigate the effects of various representative anthocyanidins on primary human epithelial cells and common sinonasal pathogens, P. aeruginosa and S. aureus. In addition to microbiologic assays, we used optical imaging of air-liquid interface (ALI) cultures of primary human sinonasal cells isolated from residual surgical material, a state-of-theart in vitro model for testing epithelial cell responses to novel compounds.…”

mentioning

confidence: 99%

In vitro Effects of Anthocyanidins on Sinonasal Epithelial Nitric Oxide Production and Bacterial Physiology

Hariri

Payne

Chen

et al. 2016

Am J Rhinol�Allergy

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confidence: 99%

In vitro Effects of Anthocyanidins on Sinonasal Epithelial Nitric Oxide Production and Bacterial Physiology

Hariri

Payne

Chen

et al. 2016

Am J Rhinol�Allergy

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“…Ciliary motility in human respiratory system has drawn much attention in recent years [37]. It is closely related to the health of respiratory system and may indirectly influence the function of other organs [38].…”

Section: Discussionmentioning

confidence: 99%

The respiratory ciliary motion produced by dynein activity alone: A computational model of ciliary ultrastructure

Chen¹,

Ren²,

Mei³

et al. 2015

THC

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Abstract. BACKGROUND:Respiratory ciliary motion is enabled by dynein/microtubule activity. Current observation techniques can hardly capture the dynein activation pattern in moving cilia. Here we introduce a computational model to mimic the ciliary ultrastructure and simulate the dynein-driven ciliary motion. METHODS: A three-dimensional model is established to mimic the "9 + 2" ciliary ultrastructure. The dynein force is simulated as point loads embedded along the microtubules. The dynein-triggered ciliary motion is solved by using the Finite Element Method along with grid deformation techniques. RESULTS: By comparing the simulated ciliary movement to the observation results, the rationality of different dynein activity hypotheses are evaluated and the dynein activation pattern that can produce the planar beating of lung cilia is proposed. The results also reveal that the dynein force alone can only generate longitudinal microtubule sliding and ciliary bending; to produce the ciliary 'curl-up' movement, transverse forces (possibly induced by radial spokes) need to be considered. CONCLUSION: This model provides a platform to investigate various assumptions of dynein activity, facilitating us to evaluate their rationality and propose possible dynein activation patterns.

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“…However, subsequent studies by the same research group demonstrated that curcumin decreased EGF-induced MUC5AC expression in lung cancer NCI-H292 cells both at protein and transcript level [84]. Similarly, curcumin pretreatment down-regulated IL-1β induced MUC5AC expression in lung airway epithelial H292 cells [86]. In addition, modulation of mucin expression by curcumin was also reported in gastrointestinal epithelial cells.…”

Section: Natural Products Modulating Mucin Expression: Potential Thermentioning

confidence: 99%

Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer

Macha

Krishn

Jahan

et al. 2015

Cancer Treatment Reviews

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Deregulated mucin expression is a hallmark of several inflammatory and malignant pathologies. Emerging evidence suggests that, apart from biomarkers, these deregulated mucins are functional contributors to pathogenesis in inflammation and cancer. Both overexpression and downregulation of mucins in various organ systems is associated with pathobiology of inflammation and cancer. Restoration of mucin homeostasis has become an important goal for therapy and management of such disorders and has fueled the quest for selective mucomodulators. With improved understanding of mucin regulation and mechanistic insights into their pathobiological roles, there is optimism to find selective non-toxic agents capable of modulating mucin expression and function. Recently, natural compounds derived from dietary sources have drawn attention due to their anti-inflammatory and anti-oxidant properties and low toxicity. Considerable efforts have been directed towards evaluating dietary natural products as chemopreventive and therapeutic agents; identification, characterization and synthesis of their active compounds; and improving their delivery and bioavailability. We describe the current understanding of mucin regulation, rationale for targeting mucins with natural products and discuss some natural products that modulate mucin expression and functions. We further discuss the approaches and parameters that should guide future research to identify and evaluate selective natural mucomodulators for therapy.

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Dietary Polyphenols Affect Muc5Ac Expression and Ciliary Movement in Respiratory Cells and Nasal Mucosa

Abstract: ABSTRACT

Cited by 27 publications

References 21 publications

In vitro Effects of Anthocyanidins on Sinonasal Epithelial Nitric Oxide Production and Bacterial Physiology

In vitro Effects of Anthocyanidins on Sinonasal Epithelial Nitric Oxide Production and Bacterial Physiology

The respiratory ciliary motion produced by dynein activity alone: A computational model of ciliary ultrastructure

Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer

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