2023
DOI: 10.1210/endocr/bqad103
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Dietary Progesterone Contributes to Intratissue Levels of Progesterone in Male Mice

Abstract: Progesterone serum levels have been identified as a potential predictor for treatment effect in men with advanced prostate cancer, which is an androgen-driven disease. Although progesterone is the most abundant sex steroid in orchiectomized (ORX) male mice, the origins of progesterone in males are unclear. To determine the origins of progesterone and androgens, we first determined the effect of ORX, adrenalectomy (ADX), or both (ORX+ADX) on progesterone levels in multiple male mouse tissues. As … Show more

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