Dietary Protein Level and Uric Acid Metabolism in Normal Man ,

Bowering, Jean; Calloway, Doris Howes; Margen, Sheldon; Kaufmann, N. A.

doi:10.1093/jn/100.2.249

Cited by 61 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies in females: Bishop et al 1954;Wyngaarden 1955;Kelley et al 1968. Studies in males: Benedict et al 1949Benedict et al , 1950Geren et al 1950;Bishop et al 1951aBishop et al , b, 1954Buzard et al 1952;Wyngaarden and Stetten 1953;Wyngaarden 1955;Sorensen 1959Sorensen , 1962Eisen and Seegmiller 1961;Seegmiller et al 1961Seegmiller et al , 1968Bowering et al 1969;Scott et al 1969;Dosman et al 1975 Males (~± SD) Females (F-t-range) …”

Section: Resultsmentioning

confidence: 99%

“…I and II, while the difference between ki and kn might be more pronounced. Bowering et al (1969) adjusted the injected dose of labeled uric acid to the pool size expected during RNA loading, and found a large increase of the fractional turnover in one subject, while in the second subject (same sex and body weight) there was only a very small change (Table 5).…”

Section: Pool Size and Turnover Of Uric Acidmentioning

confidence: 99%

“…As the uric acid secreted into the gut is completely destroyed by the intestinal flora (Sorensen 1960), intestinal uric acid excretion cannot be measured directly. Isotope dilution studies under balance conditions are necessary to measure total uric acid turnover and calculate extrarenal excretion from it.To date the isotope dilution technique described by Benedict et al (1949) has been used to study the influence of dietary purines on uric acid pool size and turnover in two healthy males (Bowering et al 1969). The oral administration of…”

mentioning

confidence: 99%

See 2 more Smart Citations

Influence of dietary purines on pool size, turnover, and excretion of uric acid during balance conditions

Löffler¹,

Gröbner²,

Medina

et al. 1982

Res. Exp. Med.

View full text Add to dashboard Cite

Pool size, turnover, and excretion of uric acid were investigated in three normal subjects both during purine-free, isoenergetic liquid formula diet and during additional purine administration by use of isotope dilution techniques. The fractional turnover of the uric acid pool was increased during dietary purine administration suggesting an increased total body uric acid clearance as a result of the increase in renal clearance. Fractional turnover increased more in the female subject than in males, while pool size was increased less. It can be calculated from the results obtained that endogenous uric acid synthesis is not inhibited by dietary purines.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Pool Size and Turnover Of Uric Acidmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Influence of dietary purines on pool size, turnover, and excretion of uric acid during balance conditions

Löffler¹,

Gröbner²,

Medina

et al. 1982

Res. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…3,28,29) This intake of RNA would result in an increase in serum uric acid of 1.13 to 1.80 mg/100ml, and an·increase in urinary uric acid of 226 to 328 mg/24 hr for normal humans. Although it has assayed a few of the common food items, the data show large differences in the amounts of individual purines making up the total purine content.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Effects of Dietary Purine and Pyrimidine Bases in Rats

Yokozawa¹,

Oura²,

Zheng³

et al. 1983

Agricultural and Biological Chemistry

View full text Add to dashboard Cite

“…Previous studies [1][2][3][4][5][6][7][8][9][10][11] have demonstrated that the urinary excretion of uric acid is increased after intake of diets containing carbohydrate and/or purine-free protein.…”

Section: Introductionmentioning

confidence: 99%

Effect of Amino Acids on the Excretions of Purine Bases and Oxypurinol

Yamamoto

Moriwaki²,

Takahashi³

et al. 1996

Nephron

View full text Add to dashboard Cite

To investigate whether or not amino acids affect the urinary excretion of purine bases and oxypurinol, a 12% amino acid solution was infused to 6 subjects who took allopurinol (300 mg) 6 h before the study. Amino acid infusion increased the urinary excretion and the fractional clearance of uric acid and oxypurinol and decreased the plasma concentration of oxypurinol. However, it affected neither the urinary excretion, the fractional clearance, the plasma concentration of oxypurines nor the plasma concentration of uric acid. These results indicate that amino acids affect the renal transport pathways of oxypurinol and uric acid but not those of oxypurines. In addition, it was suggested that the amino acid-induced increase in the urinary excretion of oxypurinol may be considered when allopurinol is administered to hyperuricemic patients with hypoproteinemia who have taken amino acids either orally or intravenously.

show abstract

Dietary Protein Level and Uric Acid Metabolism in Normal Man ,

Cited by 61 publications

References 26 publications

Influence of dietary purines on pool size, turnover, and excretion of uric acid during balance conditions

Influence of dietary purines on pool size, turnover, and excretion of uric acid during balance conditions

Metabolic Effects of Dietary Purine and Pyrimidine Bases in Rats

Effect of Amino Acids on the Excretions of Purine Bases and Oxypurinol

Contact Info

Product

Resources

About