Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet

Esterhuyse, Adriaan J; Toit, Eugene F. Du; Benadé, A. J. S.; Rooyen, Jacques Van

doi:10.1016/j.plefa.2004.10.014

Cited by 32 publications

(44 citation statements)

References 35 publications

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“…Red palm oil is distinctive from other plant and animal oil because it contains 50% saturated fatty acids, 40% unsaturated fatty acids, and 10% polyunsaturated fatty acids (Atawodi et al, 2011). RPO has beneficial effects on arterial thrombosis and hypertension associated with oxidative stress (Edem, 2002;Narang et al, 2004) and is also protective against the consequences of ischemia /reperfusion injury (Esterhuyse et al, 2005, Bester et al, 2006. Aboua et al (2009) showed that RPO could possibly inhibit apoptosis in rat sperm while its role in reducing oxidative stress in HIV/AIDS and tuberculosis patients has been reported (Oguntibeju et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Ayeleso¹,

Oguntibeju²,

Aboua³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Diabetes mellitus characterized by hyperglycaemia could affect sperm quality as a result of increased oxidative stress. This study was performed to investigate the effects of red palm oil (RPO), aqueous rooibos tea extracts (RTE) as well as their combination (RPO + RTE) on sperm motility parameters in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced by a single administration of streptozotocin (50 mg/kg) and the rats were treated with red palm oil (2 ml/day) and / or aqueous rooibos tea extract (2%) for 7 weeks. Sperm motility parameters were measured using Computer Assisted Sperm Analyzer (CASA). Results: Hyperglycaemia negatively affected the sperm progressive motility significantly at p<0.05. There was a significant decrease (p<0.05) in sperm linearity (LIN) in the diabetic group when compared with the normal control group. RPO supplemented diabetic rats exhibited increased progressive sperm motility, sperm linearity (LIN) and wobble (WOB). Significant decreases (p<0.05) in straight line velocity (VSL) and average path velocity (VAP) of the sperms were observed in all the diabetic groups when compared to the control group. Significant (p<0.05) elevated levels of WOB and LIN were observed following RTE treatment and co-administration with RPO respectively. Conclusion:The present study suggests that red palm oil and / or rooibos administration exhibited no adverse effects on sperm motility parameters but rather showed some beneficial effects.

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Section: Introductionmentioning

confidence: 99%

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Ayeleso¹,

Oguntibeju²,

Aboua³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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“…Although no evidence exists for the role of RPO in functional recovery after ischemia/reperfusion-induced injury (except for our own [1]), some evidence does exist for an effect of some of the major components of RPO on cardiac function. For example, Meehan and Higgins [16] demonstrated that oleic acid improved functional recovery in ischemic/reperfused rat hearts.…”

Section: Discussionmentioning

confidence: 68%

“…Although it was previously shown that dietary red palm oil (RPO) supplementation protects against global ischemia/reperfusion injury in the isolated perfused rat heart [1], the mechanism of action of RPO remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart?

Engelbrecht

Esterhuyse

Toit

et al. 2006

The Journal of Nutritional Biochemistry

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“…Dietary RPO supplementation has previously been shown to offer protection against ischaemia/reperfusion injury in the isolated perfused heart [10][11][12]. Esterhuyse and co-workers (2005) [10] showed that dietary RPO supplementation could improve post ischaemic functional recovery in rats fed a standard rat chow diet (SRC), and rats fed a SRC plus 2% cholesterol for six weeks [10].…”

Section: Introductionmentioning

confidence: 99%

“…The intention of the current study was therefore to use a high cholesterol feeding model to ensure that the model is more clinically relevant and to establish confirmation that red palm oil protection are indeed applicable in unhealthy diets, as was previously argued. In all red palm oil fed studies up to date [9][10][11][12], results have indicated post-ischaemic involvement of certain cellular biochemical pathways. However, none of these studies provided any evidence of pre-ischaemic protection by red palm oil.…”

Section: Introductionmentioning

confidence: 99%

Protection against ischaemia/reperfusion: role of the farnesol and red palm oil

Szűcs¹

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Background and Aims: The effect of red palm oil (RPO) supplementation on infarct size after ischaemia/ reperfusion in a cholesterol enriched diet-induced hyperlipidemic animal model has not been reported. Previous studies reported results on the effect of RPO in a normal diet, whilst evidence of protection has been linked to improved functional recovery, prosurvival kinase, anti-apoptosis and NO-cGMP. Therefore, we aimed to investigate the effects of dietary RPO supplementation in a cholesterol-enriched diet-induced hyperlipidemic rat model and to investigate the involvement of matrix metalloproteinase 2 (MMP2) inhibition as a possible mechanism of protection. Materials and Methods: Male Wistar rats were fed either a standard rat chow diet (Norm) or a 2% cholesterolenriched diet (Chol) for nine weeks. Additionally, two more groups received the same treatment, however, at the week 4, diet was supplemented with RPO for the last five weeks (Norm+RPO and Chol+RPO), respectively. After the feeding period hearts were isolated, perfused according to Langendorff and subjected to 30 minutes of normothermic global ischaemia followed by two hours of reperfusion. Infarct size was measured by 2,3,5-triphenyltetrazolium chloride staining at the end of reperfusion. Results: Cholesterol-enriched diet increased myocardial infarct size from 23.5 ± 3.0% to 37.2 ± 3.6% (p < 0.05) when compared to normal diet. RPO supplementation significantly reduced infarct size either in Norm+RPO or in Chol+RPO (to 9.2 ± 1.0% and 26.9 ± 3.0%), respectively. Infarct size in Chol+RPO was comparable to the Norm group. MMP2 activity before ischaemia was significantly reduced in the Chol+RPO group when compared to the Chol group. However, the MMP2 activity of the hearts of the RPO fed rats was significantly increased when compared to the normal diet group after ischaemia. Conclusions: For the first time it was shown that dietary RPO supplementation attenuated the increased susceptibility of the hearts in cholesterol fed rats to ischaemia/reperfusion injury. This was shown by reduced infarct size. For the first time we also show that red palm oil supplementation altered pre-ischaemic levels of MMP-2, which may indicate that myocardial MMP2 may be implicated as a possible role player in RPO mediated protection against ischaemia/reperfusion injury in hearts of cholesterol supplemented rats.

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Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet

Cited by 32 publications

References 35 publications

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart?

Protection against ischaemia/reperfusion: role of the farnesol and red palm oil

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