Dietary selenium disrupts hepatic triglyceride stores and transcriptional networks associated with growth and Notch signaling in juvenile rainbow trout

Knight, Rosalinda; Marlatt, Vicki L.; Baker, Josh A.; Lo, Bonnie P.; deBruyn, Adrian M.H.; Elphick, James R.; Martyniuk, Christopher J.

doi:10.1016/j.aquatox.2016.09.014

Cited by 29 publications

(17 citation statements)

References 54 publications

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“…ELISA [250] Farmed rainbow trout slaughtered by asphyxia or percussion [107] and found the levels to be associated with trans-3′-hydroxycotinine, a tobacco metabolite in the same samples [108]. While the concept of 15-F 2t -IsoP as the biomarker for community health assessment has only just been propositioned, the findings indicate tobacco smoking is habitual in the community of the sewage origin.…”

Section: Marine Ecosystem and Environmental Stressorsmentioning

confidence: 98%

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

Galano

Lee

Oger

et al. 2017

Progress in Lipid Research

144

153

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Since the beginning of the 1990's diverse types of metabolites originating from polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known as prostaglandin isomers (or isoprostanoids) originating from arachidonic acid, neuroprostanes from docosahexaenoic acid, and phytoprostanes from α-linolenic acid proved to be prevalent in biology. The syntheses of these compounds by organic chemists and the development of sophisticated mass spectrometry methods has boosted our understanding of the isoprostanoid biology. In recent years, it has become accepted that these molecules not only serve as markers of oxidative damage but also exhibit a wide range of bioactivities. In addition, isoprostanoids have emerged as indicators of oxidative stress in humans and their environment. This review explores in detail the isoprostanoid chemistry and biology that has been achieved in the past three decades.

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Section: Marine Ecosystem and Environmental Stressorsmentioning

confidence: 98%

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

Galano

Lee

Oger

et al. 2017

Progress in Lipid Research

144

153

View full text Add to dashboard Cite

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“…More recently, oxidative stress has been proposed as a main cause for excess dietary Se intake or exposures in fish (Berntssen et al, 2017). In Atlantic salmon fed high levels of selenite and SeMet yeast, oxidative stress was a main driver for Se toxicity (Berntssen et al, 2017); however, white sturgeon and brown trout fed high levels of organic Se did not show oxidative stress (Knight et al, 2016;Zee et al, 2016). Altered liver lipid synthesis and metabolism have been shown to be the central mechanism in dietary organic Se toxicity in rainbow trout (Knight et al, 2016;Pacitti et al, 2016).…”

Section: Toxicitymentioning

confidence: 99%

Nutrition and Metabolism of Minerals in Fish

Lall

Kaushik

2021

Preprint

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Aquatic animals have unique physiological mechanisms to absorb and retain minerals from their diets and water. Research and development in the area of mineral nutrition of farmed fish and crustaceans have been relatively slow and major gaps exist in the knowledge of trace element requirements, physiological functions and bioavailability from feed ingredients. Quantitative dietary requirements have been reported for three macroelements (calcium, phosphorus and magnesium) and six trace minerals (zinc, iron, copper, manganese, iodine and selenium) for selected fish species. Mineral deficiency signs in fish include reduced bone mineralization, anorexia, lens cataracts (zinc), skeletal deformities (phosphorus, magnesium, zinc), fin erosion (copper, zinc), nephrocalcinosis (magnesium deficiency, selenium toxicity), thyroid hyperplasia (iodine), muscular dystrophy (selenium) and hypochromic microcytic anaemia (iron). An excessive intake of minerals from either diet or gill uptake causes toxicity and therefore a fine balance between mineral deficiency and toxicity is vital for aquatic organisms to maintain their homeostasis either through increased absorption or excretion. Release of minerals from uneaten or undigested feed and from urinary excretion can cause eutrophication of natural waters, which requires additional consideration in feed formulation. The current knowledge in mineral nutrition of fish is briefly reviewed.

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“…The cause of these elevated numbers of DE transcripts is unclear but may be due to differences in species, tissue, age of the animals, and diet including vitamin E supplementation (see below). Other Se transcriptomics studies involved other factors such as aged mice/Se-enriched rice [50], diabetic mice [51], immune challenge in trout [52], transcripts in offspring after high-fat feeding to mouse dams [53], or Se-enriched worms fed to trout [54]. In livestock, high Se supplementation as selenized yeast to cattle [55] and sheep [56] relative to Se-adequate controls reported 139 and 1186 DE transcripts in cattle liver and sheep blood, respectively.…”

Section: Additional Transcriptomics Studiesmentioning

confidence: 99%

The hepatic transcriptome of the turkey poult (Meleagris gallopavo) is minimally altered by high inorganic dietary selenium

et al. 2020

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There is interest in supplementing animals and humans with selenium (Se) above Se-adequate levels, but the only good biomarker for toxicity is tissue Se. We targeted liver because turkeys fed 5 μg Se/g have hepatic Se concentrations 6-fold above Se-adequate (0.4 μg Se/ g) levels without effects on growth or health. Our objectives were (i) to identify transcript biomarkers for high Se status, which in turn would (ii) suggest proteins and pathways used by animals to adapt to high Se. Turkey poults were fed 0, 0.025, 0.4, 0.75 and 1.0 μg Se/g diet in experiment 1, and fed 0.4, 2.0 and 5.0 μg Se/g in experiment 2, as selenite, and the full liver transcriptome determined by RNA-Seq. The major effect of Se-deficiency was to downregulate expression of a subset of selenoprotein transcripts, with little significant effect on general transcript expression. In response to high Se intake (2 and 5 μg Se/g) relative to Seadequate turkeys, there were only a limited number of significant differentially expressed transcripts, all with only relatively small fold-changes. No transcript showed a consistent pattern of altered expression in response to high Se intakes across the 1, 2 and 5 μg Se/g treatments, and there were no associated metabolic pathways and biological functions that were significant and consistently found with high Se supplementation. Gene set enrichment analysis also found no gene sets that were consistently altered by high-Se and supernutritional-Se. A comparison of differentially expressed transcript sets with high Se transcript sets identified in mice provided high Se (~3 μg Se/g) also failed to identify common differentially expressed transcript sets between these two species. Collectively, this study indicates that turkeys do not alter gene expression in the liver as a homeostatic mechanism to adapt to high Se.

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Dietary selenium disrupts hepatic triglyceride stores and transcriptional networks associated with growth and Notch signaling in juvenile rainbow trout

Cited by 29 publications

References 54 publications

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

Nutrition and Metabolism of Minerals in Fish

The hepatic transcriptome of the turkey poult (Meleagris gallopavo) is minimally altered by high inorganic dietary selenium

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