Dietary selenium plus folic acid as an antioxidant therapy for ethanol‐exposed pups

Ojeda, María Luisa; Nogales, Fátima; Jotty, Karick; Barrero, M. J.; Murillo, María Luisa Ojeda; Carreras, Olimpia

doi:10.1002/bdrb.20211

Cited by 35 publications

(28 citation statements)

References 24 publications

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“…In order to improve our knowledge about the effects of ethanol on Se bioavailability in pups, we will study duodenal Se absorption. As we have previously mentioned, supplementation of ethanol-exposed pups with folic acid could improve their intestinal development; moreover, our research group has found that Se or Se plus folic acid supplementation during gestation and lactation could prevent liver oxidative damage in the pups, thus improving their development and health [10,11].…”

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confidence: 86%

“…According to what we have previously reported [8], the effects of ethanol exposure during gestation and lactation on folic acid intestinal absorption showed that intestinal folate absorption appears to be upregulated in suckling rats. Our research group has also found, in pups exposed to ethanol and supplemented with folic acid during the gestation and lactation periods, an increase in intestinal longitude (control, alcohol and alcohol plus folic acid: 53.56 ± 1.49, 43.7 ± 0.92 and 48.36 ± 1.69 cm, respectively) and intestinal mucosa weight (control, alcohol and alcohol plus folic acid: 15 ± 0.8, 12 ± 0.8 and 15 ± 1 mg/cm 2 , respectively).We have recently described that ethanol decreases selenium (Se) retention in dams, affecting their gestational parameters and the body weight, and the antioxidant balance of their progeny [9][10][11][12]. This essential trace element is of fundamental importance to health due to the antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence in at least 25 selenoproteins such as glutathione peroxidase (GPx) [13].…”

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confidence: 99%

“…57, No. 6, 2011 SELENOMETHIONINE ABSORPTION IN DUODENUM OF ETHANOL-EXPOSED RAT OFFSRPING 709 their intestinal development; moreover, our research group has found that Se or Se plus folic acid supplementation during gestation and lactation could prevent liver oxidative damage in the pups, thus improving their development and health [10,11].At present, a limited number of studies have explored Se uptake in offspring rats [16] or infants [17,18], and there are no reports concerning this in ethanol-exposed pups. In this context, Anan et al (2009) [19] found that suckling pups mainly obtained Se presenting in breast-milk in organic form as Se-Met.…”

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confidence: 99%

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confidence: 99%

“…We have recently described that ethanol decreases selenium (Se) retention in dams, affecting their gestational parameters and the body weight, and the antioxidant balance of their progeny [9][10][11][12]. This essential trace element is of fundamental importance to health due to the antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence in at least 25 selenoproteins such as glutathione peroxidase (GPx) [13].…”

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Effects of Antioxidant Supplementation on Duodenal Se-Met Absorption in Ethanol-exposed Rat Offspring In Vivo

Nogales

Ojeda

Delgado

et al. 2011

Journal of Reproduction and Development

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Abstract. The nutritional deficiencies provoked by ethanol consumption, during gestation or lactation, can contribute to multiple birth defects in offspring. In order to improve our knowledge about selenium (Se) distribution in pups exposed to ethanol, the present study evaluated the effect of this drug on intestinal development and determined its action on duodenal absorption of selenomethionine (Se-Met). To determinate if supplementation could improve Se absorption and its serum values, we used two antioxidant supplemented regimens on dams, with selenium alone or selenium plus folic acid, and obtained six groups of pups: C (control), A (alcohol), CS (control + Se), AS (alcohol + Se), CFS (control + Se + folic acid) and AFS (alcohol + Se + folic acid). Duodenal Se-Met transport was performed using an in vivo perfusion method. Se levels were measured by graphite furnace atomic absorption spectrometry. The supplemented diets utilized had a positive influence on body growth, duodenal perimeter and Se content in ethanol-exposed pups. Ethanol exposure increased Se-Met duodenal absorption in all pups, supplemented or not, presenting the highest values of maximal velocity (V max ) compared with their control counterparts. The affinity constant (K m ) increased according to rank: A>AS>AFS groups. These results suggest that although antioxidant supplementation does not restore Se-Met absorption to normal values, it enhances the affinity of the transporters for the substrate and improves the damage caused by ethanol in the duodenal mucosa.Key words: Ethanol, Kinetic parameters, Offspring development, Selenomethionine absorption (J. Reprod. Dev. 57: [708][709][710][711][712][713][714] 2011) T he primary function of the intestinal epithelium is to absorb the small molecules produced from food digestion [1]. However, specific substances such as alcohol could alter this intestinal absorption [2,3], producing malnutrition. Numerous studies have demonstrated that chronic ethanol consumption induces morphological and biochemical alterations in the intestinal mucosal cells [4] and that some of these changes are caused by a lipid peroxidation of duodenal membrane lipids [5]. These effects of ethanol exposure are more acute during pregnancy and lactation and can contribute to a delay in offspring growth and multiple birth defects, including fetal alcohol syndrome [6]. In this context, it is especially relevant that ethanol deregulates the homeostasis of different antioxidants such as folic acid, whose deficiency is the most common sign of malnutrition in chronic alcoholism [7]. This deficiency is associated with several alterations such as Down's syndrome and defects in neural tube closure in developing embryos [1]. According to what we have previously reported [8], the effects of ethanol exposure during gestation and lactation on folic acid intestinal absorption showed that intestinal folate absorption appears to be upregulated in suckling rats. Our research group has also found, in pups exposed to ethanol and supplemented wit...

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confidence: 86%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Antioxidant Supplementation on Duodenal Se-Met Absorption in Ethanol-exposed Rat Offspring In Vivo

Nogales

Ojeda

Delgado

et al. 2011

Journal of Reproduction and Development

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Emodin Prevents Ethanol‐Induced Developmental Anomalies in Cultured Mouse Fetus through Multiple Activities

Yon

Cai

et al. 2013

Birth Defects Research Pt B

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Effects of rumen‐protected folic acid and rumen‐protected sodium selenite supplementation on lactation performance, nutrient digestion, ruminal fermentation and blood metabolites in dairy cows

Wang

et al. 2019

J Sci Food Agric

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BACKGROUND Considering the insufficient ruminal synthesis of folic acid (FA), the higher degradability of FA, and the reduction of sodium selenite (SS) by ruminal microbes into non‐absorbable elemental Se, this study evaluated the effects of rumen‐protected FA (RPFA) and rumen‐protected SS (RPSS) on lactation performance, nutrient digestion and blood metabolites in dairy cows. RESULTS Dry matter (DM) intake and milk composition were unaltered, milk and milk fat yields were higher for both supplements, and milk protein yield was higher for RPFA addition. Digestibility of DM, neutral detergent fibre and acid detergent fibre was higher for both supplements, whereas that of organic matter and crude protein was higher for RPFA addition. Ruminal pH and ammonia N were lower, and concentration of total volatile fatty acids was higher for both supplements. Activity of cellobiase and xylanase was higher for RPFA addition, whereas that of pectinase and protease was higher for both supplements. The populations of total ruminal fungi, protozoa, Ruminococcus flavefaciens and Butyrivibrio fibrisolvens were higher for both supplements. The RPFA × RPSS interaction was significant for α‐amylase activity, total ruminal bacteria and R. albus populations; these three variables were increased by RPSS but the increase was greater when cows were also fed RPFA. CONCLUSION The results indicated that addition of RPFA or RPSS improved lactation performance, nutrient digestibility and ruminal fermentation in dairy cows by stimulating ruminal microbial growth and enzyme activity. © 2019 Society of Chemical Industry

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Dietary selenium plus folic acid as an antioxidant therapy for ethanol‐exposed pups

Abstract: These results suggest that folic acid+Se could be effective in neutralising the damage of ethanol consumption in pups since it prevents peroxidation protein products.

Cited by 35 publications

References 24 publications

Effects of Antioxidant Supplementation on Duodenal Se-Met Absorption in Ethanol-exposed Rat Offspring In Vivo

Effects of Antioxidant Supplementation on Duodenal Se-Met Absorption in Ethanol-exposed Rat Offspring In Vivo

Emodin Prevents Ethanol‐Induced Developmental Anomalies in Cultured Mouse Fetus through Multiple Activities

Effects of rumen‐protected folic acid and rumen‐protected sodium selenite supplementation on lactation performance, nutrient digestion, ruminal fermentation and blood metabolites in dairy cows

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