Dietary Selenized Glucose Increases Selenium Concentration and Antioxidant Capacity of the Liver, Oviduct, and Spleen in Laying Hens

Zhao, Minmeng; Sun, Qingyun; Khogali, Mawahib K.; Liu, Long; Geng, Tuoyu; Yu, Lei; Gong, Daoqing

doi:10.1007/s12011-021-02603-7

Cited by 21 publications

(13 citation statements)

References 35 publications

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“…HPLC analysis revealed that SeCM extract contained particularly abundant phenolic acids and flavonoids such as luteolin, which could form the chemical basis for their influences on SOD and CAT activities in fruit flies. On the other hand, selenium is an element essential to selenium‐dependent glutathione peroxidase, which catalyzes the reduction of hydrogen peroxide to water with assistance of glutathione (Chafik et al, 2019; Zhao et al, 2021). Similar to SOD and CAT, activities of glutathione peroxidase were found to increase drastically when fruit flies were fed with SeCM extract (J. Feng et al, unpublished data).…”

Section: Resultsmentioning

confidence: 99%

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Feng

Xiao

et al. 2022

Journal of Food Biochemistry

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Chrysanthemum morifolium is a well‐known edible medicinal plant in Asia and some other regions. Content of selenium in Se‐enriched C. morifolium (SeCM) is significantly higher than that in traditional C. morifolium (non‐Se‐enriched C. morifolium, TCM). In order to understand health effects of SeCM, its chemical composition, lifespan‐prolonging activities, and impacts on antioxidant defense‐related gene expressions of model organism D. melanogaster were systematically studied. A total of eight phenols, including luteolin‐7‐O‐glucoside, linarin, luteolin, apigenin, diosmetin, acacetin, 3‐caffeoylquinic acid and 4,5‐dicaffeoylquinic acid, were identified in SeCM extract. Compared with TCM, SeCM exhibited superior antioxidant properties. Intake of SeCM dramatically reduced malondialdehyde level and increased activities of endogenous antioxidant enzymes in fruit flies. SeCM was able to upregulate gene expressions of Cu/Zn‐superoxide dismutase, Mn‐superoxide dismutase and hydrogen peroxide catalase, and extend lifespans of fruit flies. Comparatively high antioxidant capacities and lifespan‐prolonging activities of SeCM might be attributed to its abundant phenols and selenium, which probably ameliorated accumulation of free radicals and susceptibility to oxidative stress. These findings provide clues on further exploitation and utilization of Se‐enriched C. morifolium. Practical applications Chrysanthemum morifolium has been used for nutraceutical and curative purposes in China for thousands of years. Se‐enriched C. morifolium typically contains more selenium than traditional C. morifolium, and is widely consumed in Asia and some other regions. Selenium is an essential micronutrient for humans, and selenium deficiency may result in several diseases such as myocardial infarction. SeCM is one of important selenium supplements. In this study, SeCM was found to upregulate gene expressions of Cu/Zn‐superoxide dismutase, Mn‐superoxide dismutase, and hydrogen peroxide catalase, and extend lifespans of experimental animals. These results provide supporting information for developing SeCM‐based functional foods with distinct health benefits.

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Section: Resultsmentioning

confidence: 99%

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Feng

Xiao

et al. 2022

Journal of Food Biochemistry

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“…The above data were the same as the result of oxidative damage caused by Cr 6+ in Chinese lobster [ 39 ]. Furthermore, a study found that the content of GSH and the levels of SOD were slightly increased when supplementing appropriate SeY to increase the organism’s antioxidant system in spleen tissues [ 40 ]. These indicated that Cr 6+ -induced oxidative damage and SeY could maintain a better antioxidant system in spleen tissues.…”

Section: Discussionmentioning

confidence: 99%

Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

Zhao

Hao

Zhang

et al. 2022

Animals

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This study was conducted to investigate the molecular mechanisms of selenium (Se) antagonism of hexavalent chromium (Cr6+)-induced toxicity. Potassium dichromate (K2Cr2O7) and selenium-enriched yeast (SeY) were used to construct the single Cr6+ and combined Se/Cr6+ exposure broiler models, and then the broilers were randomly divided into four groups (C group, Se group, Se/Cr6+ group, and Cr6+ group). After a 42-day experiment, the spleen tissues of broilers were excised and weighted. The antagonistic mechanisms of Se and Cr6+ were evaluated using histopathological assessment, serum biochemical tests, oxidative stress kits, ELISA, qPCR, and Western blotting. On the whole, there were no significant changes between the C and Se groups. The spleen organ index in the Cr6+ group was significantly decreased, but SeY increased spleen organ index to a certain extent. The levels of SOD and GSH were reduced, and the MDA content was elevated by Cr6+; however, these changes were mitigated by Se/Cr6+ exposure. Importantly, Cr6+ exposure induced a series of histopathological injuries in broiler spleen tissues, while these symptoms were significantly relieved in the Se/Cr6+group. Furthermore, Cr6+ significantly decreased the levels of T-globulin, IgA, IgM, and IgG in serum. Contrarily, dramatically more T-globulin IgA, IgM, and IgG were found in the Se/Cr6+group than in the Cr6+ group. Revealed by the results of qPCR and WB, the expressions of NF-κB, IκBα, and p-IκBα were upregulated in Cr6+ groups, while they were downregulated in Se/Cr6+ group compared to that in Cr6+ group. Besides IFN-γ and IL-2, the expressions of pro-inflammatory cytokines were significantly increased by Cr6+ exposure, but the SeY supplement relived the expression levels mediated by Cr6+ exposure. In conclusion, our findings suggest SeY has biological activity that can protect broiler spleens from immunosuppression and inflammation induced by Cr6+, and we speculate that the NF-κB signaling pathway is one of its mechanisms.

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“…The oxidative stress theory is one of the most prevalent ideas for how aging happens at the molecular level [ 1 ]. During the aging process in laying hens, harmful reactive oxygen species (ROS) are gradually produced, resulting in oxidative stress damage, including a decrease in liver antioxidant capacity [ 2 , 3 ], changes in intestinal oxidative state [ 4 ], and the aging of reproductive organs [ 5 , 6 ], which lead to a decline in egg production performance. Oxidative stress reaches its peak when the hen is about 65 to 70 weeks old [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Rutin Supplementation on the Intestinal Morphology, Antioxidant Capacity, Immunity, and Microbiota of Aged Laying Hens

Jin

et al. 2022

Antioxidants

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This research investigated the effects of dietary rutin supplementation on the intestinal morphology, antioxidant capacity, immunity, and microbiota of aged laying hens. The results showed that 500 mg/kg rutin supplementation increased the villus height of jejunum (P < 0.05). Rutin affected the immune system of the ileum and the jejunum. In the jejunum, a diet with 500 mg/kg rutin supplementation enhanced secretory immunoglobulin A (sIgA) and reduced tumor necrosis factor-α (TNF-α) levels (P < 0.05). A diet with 1000 mg/kg rutin supplementation increased jejunal sIgA, immunologlobulin M (IgM), and interleukin-4 (IL-4) levels while decreasing interleukin-1β (IL-1β), TNF-α, and interferon-γ (IFN-γ) levels (P < 0.05). Meanwhile, a diet with 500 mg/kg rutin increased sIgA, immunologlobulin G (IgG), IgM, and interleukin-10 (IL-10) levels and reduced TNF-α and IFN-γ levels in the ileum (P < 0.05). In the ileum, a diet with 1000 mg/kg rutin supplementation raised sIgA, IgG, IgM, IL-4, and IL-10 levels while decreasing IL-1β, TNF-α, and IFN-γ levels (P < 0.05). At the family level, a diet with 500 mg/kg rutin supplementation raised the relative abundance of Monoglobaceae and decreased the relative abundance of Eubacteriaceae (P < 0.05) compared to the control group. In the 1000 mg/kg rutin group, the relative abundance of Lactobacillaceae and Unclassified Coriobacteriale was considerably lower and the relative abundance of Monoglobaceae was higher than the control group (P < 0.05). This study showed that a diet with rutin supplementation can improve the intestinal health of aged laying hens, and the mechanism is related to improving the intestinal morphology and intestinal immune status, and regulating the intestinal microbes.

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Dietary Selenized Glucose Increases Selenium Concentration and Antioxidant Capacity of the Liver, Oviduct, and Spleen in Laying Hens

Cited by 21 publications

References 35 publications

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Effects of Se‐enriched Chrysanthemum morifolium on lifespan and antioxidant defense‐related gene expression of Drosophila melanogaster model

Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

Effects of Dietary Rutin Supplementation on the Intestinal Morphology, Antioxidant Capacity, Immunity, and Microbiota of Aged Laying Hens

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