Dietary Sodium Loading Increases Plasma Brain Natriuretic Peptide Levels in Man

Lang, CC; Coutie, Wendy J.; Khong, TK; Robson, John; Struthers, AD

doi:10.1042/cs081024pa

Cited by 10 publications

(11 citation statements)

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“…26,27 In 1998, Jensen and co-workers 27 undertook a dose-response study in 48 healthy male volunteers to observe the effects of continuous BNP infusion for 60 minutes. The infusion increased urine flow rate and sodium excretion in a dose-dependent way while decreasing the renal plasma flow and increasing the glomerular filtration rate, also in a dose-dependent fashion.…”

Section: Effect Of Bnp On Renal Hemodynamics and Tubular Functionmentioning

confidence: 98%

Role of B-Type Natriuretic Peptide and Effect of Nesiritide After Total Cardiac Replacement With the AbioCor Total Artificial Heart

Delgado¹,

Wadia²,

Kar³

et al. 2005

The Journal of Heart and Lung Transplantation

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Section: Effect Of Bnp On Renal Hemodynamics and Tubular Functionmentioning

confidence: 98%

Role of B-Type Natriuretic Peptide and Effect of Nesiritide After Total Cardiac Replacement With the AbioCor Total Artificial Heart

Delgado¹,

Wadia²,

Kar³

et al. 2005

The Journal of Heart and Lung Transplantation

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“…However, plasma levels of BNP are increased, although to a smaller extent than ANP (i.e. approximately 2-fold), after several days of a high sodium intake compared with a low sodium diet [28,29]. At the cellular level, ANP is stored predominantly in secretion granules thereby providing a source for rapid release.…”

Section: Figure 1 Schematic Representation Of the Anp And Bnp Precursmentioning

confidence: 99%

“…Most radioimmunoassay methods for the measurement of plasma BNP [24][25][26][27][28][29][30][31] are also based on extraction on solid-phase resin (e.g. C-18).…”

Section: Figure 1 Schematic Representation Of the Anp And Bnp Precursmentioning

confidence: 99%

Measurement and significance of circulating natriuretic peptides in cardiovascular disease

1998

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1. The major cardiovascular and renal actions of alpha-atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) and the fact that the heart is strategically located to sense changes in intravascular volume indicate the importance of these peptides in the overall control of the extracellular fluid volume under normal and pathophysiological conditions.2. This review examines the clinical and diagnostic significance of the measurement of plasma natriuretic peptides in diseases of the cardiovascular system with particular emphasis on the assessment of patients with heart failure. 3. Raised plasma levels of ANP and BNP have repeatedly been found in patients with heart disease originating from diverse causes including tachycardias, valvular stenosis or ventricular dysfunction. The raised circulating levels of natriuretic peptide (ANP, N-terminal proANP and BNP in particular) are associated with (i) raised atrial and pulmonary wedge pressures; (ii) reduced ventricular systolic and diastolic function; (iii) presence (and possibly geometric form) of left ventricular hypertrophy; and (iv) severe myocardial infarction. Although both plasma ANP and BNP are raised in the presence of left ventricular hypertrophy, BNP appears to be a better index of left ventricular hypertrophy.4. Several situations where the measurement of natriuretic peptides may be of benefit in the overall assessment of heart disease are discussed. However, it is emphasized that the measurement of plasma natriuretic peptides alone appears to be of limited value as a specific diagnostic tool, given that raised levels are a consequence of haemodynamic and structural abnormalities arising from diverse pathological processes. Despite these limitations, the major value of plasma natriuretic peptides in the examination of patients with suspected heart disease rests on the premise that: (i) a normal value would not be consistent with cardiac disease; (ii) the presence of markedly raised levels may help to target those for subsequent detailed assessment of underlying cardiac dysfunction; and (iii) markedly raised levels of plasma natriuretic peptides after myocardial infarction can identify those at high risk of death.

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“…The first methods set up for BNP determination was RIAs [44][45][46][47]. BNP immunoassays share the same analytical problems and difficulties affecting ANP ones.…”

Section: Determination Of Bnp and Nt-probnpmentioning

confidence: 99%