Dietary Supplementation of Brevibacillus laterosporus S62-9 Improves Broiler Growth and Immunity by Regulating Cecal Microbiota and Metabolites

Zhi, Tongxin; Ma, Aijin; Liu, Xiangfei; Zhou, C.; Li, Siting; Jia, Yingmin

doi:10.1007/s12602-023-10088-0

Cited by 4 publications

(4 citation statements)

References 49 publications

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“…B. laterosporus has been added to animal feed, and the improvements in the growth of farmed animals are shown in Table 2. The meat quality of broilers could be enhanced through significant improvements in breast muscle color (0.5% decrease in lightness and 0.54% increase in redness) as well as muscle chemistry (0.05% increase in protein content) [52] Supplementation of the broiler diet with B. laterosporus S62-9 resulted in a significant 7.2% increase in broiler weight, accompanied by a remarkable reduction of 5.19% in the feed conversion rate and enhancement of the immune response [48]. Adding B. laterosporus Texasporus to the diet of broilers infected with Salmonella effectively counteracted the decline in performance and the increase in the immune factor IgM induced by the pathogenic bacteria [49].…”

Section: Regulation Of Animal Growthmentioning

confidence: 99%

“…Supplementation of the broiler diet with B. laterosporus S62-9 resulted in a significant 7.2% increase in broiler weight, accompanied by a remarkable reduction of 5.19% in the feed conversion rate and enhancement of the immune response [ 48 ]. Adding B. laterosporus Texasporus to the diet of broilers infected with Salmonella effectively counteracted the decline in performance and the increase in the immune factor IgM induced by the pathogenic bacteria [ 49 ].…”

Section: The Probiotic Effects Of B Laterosporus O...mentioning

confidence: 99%

“…The regulation of the intestinal flora structure by B. laterosporus enhances disease resistance, promotes the relative abundance of beneficial bacteria, and inhibits the proliferation of harmful microorganisms. Feeding with B. laterosporus S62-9 significantly enhanced the relative abundance of beneficial bacteria ( Adlercreutzia , Akkermansia , Lactobacillus , Intestinimonas , and Ruminococcus ) in the broiler cecum while reducing the relative abundance of harmful bacteria ( Pseudomonas , Klebsiella , Cupriavidus , and Ralstonia ) [ 48 ]. B. laterosporus sustains intestinal immune function by competing with pathogenic microorganisms on the mucosa to inhibit colonization and promote intestinal health.…”

Section: The Probiotic Effects Of B Laterosporus O...mentioning

confidence: 99%

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Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Liu,

Zai,

Weng

et al. 2024

Microorganisms

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Brevibacillus laterosporus (B. laterosporus) is widely distributed in nature and demonstrates significant potential for applications in biological control, environmental protection, agricultural production, and clinical medicine. This review provides a comprehensive overview of the applications of B. laterosporus in crop cultivation and animal feeding, as well as an examination of the antimicrobial peptides produced by B. laterosporus and their antibacterial mechanisms. B. laterosporus enhances crop cultivation by secreting hydrolases to improve nutrient absorption capabilities, synthesizing hormones to promote crop growth, and producing proteins to inhibit the reproduction of harmful organisms. B. laterosporus has been used to improve animal production by regulating the structure of the intestinal microbiota and inhibiting the growth of pathogenic bacteria through the secretion of various antimicrobial peptides. The bactericidal activity of Brevilaterins secreted by B. laterosporus is attributed to their ability to bind to lipopolysaccharide/lipid II molecules on the cell membrane, thereby altering permeability. Brevilaterins also inhibit bacterial reproduction by affecting relevant gene pathways in the cell membranes of pathogenic bacteria. These pathways include ATP synthesis, peptidoglycan biosynthesis, membrane transport, and cellular metabolism. In conclusion, B. laterosporus exhibits substantial potential as a probiotic activity in crop and animal production. However, applications of B. laterosporus in animal production could be improved, necessitating further research to elucidate the underlying probiotic mechanisms.

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Section: Regulation Of Animal Growthmentioning

confidence: 99%

Section: The Probiotic Effects Of B Laterosporus O...mentioning

confidence: 99%

Section: The Probiotic Effects Of B Laterosporus O...mentioning

confidence: 99%

See 1 more Smart Citation

Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Liu,

Zai,

Weng

et al. 2024

Microorganisms

View full text Add to dashboard Cite

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“…Often, changes in microbial community composition are accompanied by changes in the metabolic profiles. The interaction between beneficial metabolites and intestinal epithelial cells helps to maintain the intestinal mucosal barrier, thereby reducing the risk of gut-associated infections and disease [12]. The mammalian gut microbial community forms a complex mutualism with its host, which has profound implications for overall health.…”

Section: Introductionmentioning

confidence: 99%

Partially Alternative Feeding with Fermented Distillers’ Grains Modulates Gastrointestinal Flora and Metabolic Profile in Guanling Cattle

He,

Chen,

Mei

et al. 2023

Animals

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Fermented distillers’ grains (FDG) are commonly used to enhance the health and metabolic processes of livestock and poultry by regulating the composition and activity of the intestinal microbiota. Nevertheless, there is a scarcity of research on the effects of the FDG diet on the gastrointestinal microbiota and its metabolites in cattle. This study examines the impact of FDG dietary supplements on the gastrointestinal flora and metabolic profile of Guanling cattle. Eighteen cattle were randomly assigned to three treatment groups with six replicates per group. The treatments included a basal diet (BD), a 15% concentrate replaced by FDG (15% FDG) in the basal diet, and a 30% concentrate replaced by FDG (30% FDG) in the basal diet. Each group was fed for a duration of 60 days. At the conclusion of the experimental period, three cattle were randomly chosen from each group for slaughter and the microbial community structure and metabolic mapping of their abomasal and cecal contents were analyzed, utilizing 16S rDNA sequencing and LC-MS technology, respectively. At the phylum level, there was a significant increase in Bacteroidetes in both the abomasum and cecum for the 30%FDG group (p < 0.05). Additionally, there was a significant reduction in potential pathogenic bacteria such as Spirochetes and Proteobacteria for both the 15%FDG and 30%FDG groups (p < 0.05). At the genus level, there was a significant increase (p < 0.05) in Ruminococcaceae_UCG-010, Prevotellaceae_UCG-001, and Ruminococcaceae_UCG-005 fiber degradation bacteria. Non-target metabolomics analysis indicated that the FDG diet significantly impacted primary bile acid biosynthesis, bile secretion, choline metabolism in cancer, and other metabolic pathways (p < 0.05). There is a noteworthy correlation between the diverse bacterial genera and metabolites found in the abomasal and cecal contents of Guanling cattle, as demonstrated by correlation analysis. In conclusion, our findings suggest that partially substituting FDG for conventional feed leads to beneficial effects on both the structure of the gastrointestinal microbial community and the metabolism of its contents in Guanling cattle. These findings offer a scientific point of reference for the further use of FDG as a cattle feed resource.

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A multitissue transcriptomic analysis reveals a potential mechanism whereby Brevibacillus laterosporus S62-9 promotes broiler growth

Zhi,

Ma,

Liu

et al. 2024

Poultry Science

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Dietary Supplementation of Brevibacillus laterosporus S62-9 Improves Broiler Growth and Immunity by Regulating Cecal Microbiota and Metabolites

Cited by 4 publications

References 49 publications

Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Brevibacillus laterosporus: A Probiotic with Important Applications in Crop and Animal Production

Partially Alternative Feeding with Fermented Distillers’ Grains Modulates Gastrointestinal Flora and Metabolic Profile in Guanling Cattle

A multitissue transcriptomic analysis reveals a potential mechanism whereby Brevibacillus laterosporus S62-9 promotes broiler growth

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