Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3-β pathway

Cui, Zhifu; Jin, Ningning; Amevor, Felix Kwame; Shu, Gang; Du, Xiaxia; Kang, Xincheng; Ning, Zifan; Deng, Xun; Tian, Yaofu; Zhu, Qing; Wang, Yan; Li, Diyan; Zhang, Yao; Wang, Xiaoqi; Han, Xue; Feng, Jing; Zhao, Xiaoling

doi:10.1016/j.psj.2022.102034

Cited by 20 publications

(8 citation statements)

References 71 publications

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“…AMPK activates the expression of dexamethasone through PPARγ to accumulate lipid droplets in mouse liver [ 61 ]. THRSP is also involved in fat metabolism, and THRSP has also been reported as a key gene affecting fat deposition in pig muscle [ 62 ]. THRSP gene is associated with liver synthesis and abdominal fat traits in chickens and could be used as a candidate gene for further study.…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq Analysis Reveals the Molecular Mechanisms Regulating the Development of Different Adipose Tissues in Broiler Chicks

Wei,

Kang,

Amevor

et al. 2024

Animals

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In an effort to enhance growth rates, chicken breeders have undertaken intensive genetic selection. In the selection process, the primary aim is to accelerate growth, inadvertently leading to new chicken breeds having an increased capacity for rapid adipose tissue accumulation. However, little is known about the relationship between changes in gene expression and adipose tissue accumulation and deposition in chickens. Therefore, in this study, RNA-seq analysis was utilized, and transcriptome data were obtained from the abdominal fat, thoracic subcutaneous fat, and clavicular fat on day 1 (d1), day 4, day 7, day 11, and day 15 to reveal the molecular mechanisms regulating the development and deposition of different adipose tissues in broiler chicks. The results showed that the key period for adipocyte differentiation and proliferation was between d4 and d7 (abdominal fat development) and between d1 and d4 (chest subcutaneous fat and clavicular fat). In addition, candidate genes such as MYOG, S100A9, CIDEC, THRSP, CXCL13, and NMU related to adipose tissue growth and development were identified. Further, genes (HOXC9, AGT, TMEM182, ANGPTL3, CRP, and DSG2) associated with the distribution of adipose tissue were identified, and genes (MN1, ANK2, and CAP2) related to adipose tissue growth were also identified. Taken together, the results from this study provide the basis for future studies on the mechanisms regulating adipose tissue development in chickens. Further, the candidate genes identified could be used in the selection process.

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Section: Discussionmentioning

confidence: 99%

RNA-Seq Analysis Reveals the Molecular Mechanisms Regulating the Development of Different Adipose Tissues in Broiler Chicks

Wei,

Kang,

Amevor

et al. 2024

Animals

Self Cite

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“…This condition is primarily linked to the nutritional composition of their diet and excessive feed intake ( Yang et al, 2017 ). It has been proven that adding an appropriate amount of oil to the diet of laying hens is one of the effective methods to construct the FLHS model ( Song et al, 2017 ; Cui et al, 2022 ). Research has shown that plant extracts contain natural molecular compounds that can effectively reduce lipid metabolism in poultry ( Xie et al, 2019b ).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism

Chu,

Zheng,

et al. 2024

Poultry Science

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“…Overdosing on energy (a condition of nutrient excess) is the major factor causing the disease, and changing diets can efficiently prevent chicken FLHS [ 11 , 12 , 13 ]. Dietary supplements have been used for improving hepatic and blood indexes related to FLHS, which provides a new strategy for preventing FLHS occurrence rate in laying flocks [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Fatty Liver Hemorrhage Syndromementioning

confidence: 99%

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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Osteocalcin (OCN) is synthesized and secreted by differentiating osteoblasts. In addition to its role in bone, OCN acts as a hormone in the pancreas, liver, muscle, fat, and other organs to regulate multiple pathophysiological processes including glucose homeostasis and adipic acid metabolism. Fat metabolic disorder, such as excessive fat buildup, is related to non-alcoholic fatty liver disease (NAFLD) in humans. Similarly, fatty liver hemorrhage syndrome (FLHS) is a metabolic disease in laying hens, resulting from lipid accumulation in hepatocytes. FLHS affects hen health with significant impact on poultry egg production. Many studies have proposed that OCN has protective function in mammalian NAFLD, but its function in chicken FLHS and related mechanism have not been completely clarified. Recently, we have revealed that OCN prevents laying hens from FLHS through regulating the JNK pathway, and some pathways related to the disease progression have been identified through both in vivo and vitro investigations. In this view, we discussed the current findings for predicting the strategy for using OCN to prevent or reduce FLHS impact on poultry production.

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Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3-β pathway

Cited by 20 publications

References 71 publications

RNA-Seq Analysis Reveals the Molecular Mechanisms Regulating the Development of Different Adipose Tissues in Broiler Chicks

RNA-Seq Analysis Reveals the Molecular Mechanisms Regulating the Development of Different Adipose Tissues in Broiler Chicks

Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

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