Dietary total flavonoids intake and risk of mortality from all causes and cardiovascular disease in the general population: A systematic review and meta‐analysis of cohort studies

Abstract

The meta-analysis provides strong evidence for the recommendation of consuming flavonoids-rich food to reduce risks of mortality from all causes as part of a healthy diet among general adults.

Associations between habitual flavonoid intake and hospital admissions for atherosclerotic cardiovascular disease: a prospective cohort study

“…Our study cohort had a median age of 56 years (IQR 52-60) at entry and a median follow-up of 21 years (15)(16)(17)(18)(19)(20)(21)(22). During a total of 939 031 person-years of followup, 8773 individuals were admitted to hospital for any atherosclerotic cardiovascular disease, 5323 for ischaemic heart disease, 2920 for ischaemic stroke, and 1867 for peripheral artery disease.…”

“…Flavonoid intake in Denmark is similar to intakes reported for other European countries and generally lower than intakes reported for the UK, because of a lower average consumption of tea. 13 In the past few years, studies assessing the relationship between flavonoid intake and cardiovascular disease have focused primarily on mortality from any cardiovascular disease 18 or coronary heart disease and ischaemic stroke, both indivi dually and combined. 19,20 A 2017 meta-analysis found that total flavonoid intake was marginally, but not significantly, associated with a lower risk of cardiovascular disease mortality (relative risk 0·85, 95% CI 0·70-1·03) for the highest versus lowest category of total flavonoid intake; 18 similar risk estimates have been reported in other meta-analyses.…”

“…23 Although a trend for a reduced risk of cardiovascular disease with higher levels of flavonoid intake exists, this is generally non-significant after adjusting for potential con founders. 18 In this study, we used hospital admission for ischaemic heart disease, ischaemic stroke, and peripheral artery disease as markers of atherosclerotic and thromboembolic cardio vascular disease rather than an unselective array of cardiovascular disease diagnoses. These events were our chosen outcomes of interest because in-vivo evidence suggests that flavonoids might impede the initiation and progress ion of atherosclerosis by restoring endothelial homoeo stasis and attenuating inflammation.…”

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

“…They are usually provided to the food as color, flavor, bitter, and astringent, and maintain stability from oxidation. Several epidemiological studies and associated meta-analyses strongly showed that the consumption of these polyphenols offered better protection against chronic diseases such as cancers, cardiovascular diseases, cerebrovascular diseases, diabetes, ageing and neurodegenerative diseases [2,3,4,5]. …”

Sugar intake and all-cause mortality—differences between sugar-sweetened beverages, artificially sweetened beverages, and pure fruit juices

“…The fact that SSBs contain added sugars and pure fruit juice contains natural sugars could be one of the possible explanations for the different associations with all-cause mortality. Furthermore, in contrast to SSBs, pure fruit juice contains polyphenols which are associated with a lower all-cause mortality risk [4]. ASBs also initially appeared to be associated with all-cause mortality in the highest intake category (more than two ASBs per day).…”