Dietary tributyrin improves reproductive performance, antioxidant capacity, and ovary function of broiler breeders

Wang, Jianping; Zhang, Hongye; Bai, Shiping; Zeng, Qiufeng; Su, Zuowei; Zhuo, Yong; Mao, Xiangbing; Yin, Huadong; Feng, Bin; Liu, Jingbo; Zhang, Keying; Ding, Xuemei

doi:10.1016/j.psj.2021.101429

Cited by 17 publications

(15 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study reported that hepatic fat accumulation is positively correlated with apoptosis in the ovaries in broiler breeder hens [ 6 ]. Additionally, it has been demonstrated that breeders with lower egg laying rates had higher ovarian-cell apoptosis rates [ 45 ]. Bcl-2 family proteins play important roles in the regulation of cellular apoptosis, among which Bcl-2 is the most representative anti-apoptotic protein, whereas Bax exhibits pro-apoptotic activity [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Feng

Fan

Zhao

et al. 2022

Animals

View full text Add to dashboard Cite

This study aimed to investigate the role of chitosan oligosaccharide (COS) as an additive in the feed of laying hens with fatty liver syndrome (FLS). Effects on production performance, egg quality as well as ovarian function were determined. A total of 360 Lohmann Pink-shell laying hens (28 weeks old) were randomly assigned to 5 groups (6 replicates × 12 birds). Hens were fed with a basal diet and a high-energy low-protein (HELP) diet supplemented with 0, 200, 400 and 800 mg/kg COS. COS reversed the lowered laying rates, increased feed-to-egg ratios and decreased albumen heights and Haugh units induced by the HELP diet. Additionally, COS improved the ovarian morphologies damaged by the HELP diet. Furthermore, COS enhanced antioxidant enzyme activities, reduced malonaldehyde levels and downregulated the mRNA expressions of nuclear factor kappa B, pro-inflammation cytokine genes and pro-apoptosis-related genes, while it upregulated the mRNA expression of anti-apoptosis-related genes in the ovaries of HELP-diet-fed hens. These findings suggested that dietary COS supplementation could improve production performance and egg quality in laying hens with FLS, and these beneficial effects were linked to improved ovarian morphology, which was attributed to decreased oxidative stress, inflammation and apoptosis in the ovaries.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Feng

Fan

Zhao

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…Dietary supplementation with tributyrin has been demonstrated to improve animal production performance and disease resistance in monogastrics [ 27 , 28 , 29 ] and ruminants [ 30 ]. Notably, the positive effect of tributyrin may be attributed to the production of butyrate, which can promote the proliferation and differentiation of intestinal mucosal cells and improve nutrient absorption and utilization [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Tributyrin on Growth Performance, Biochemical Indices, and Intestinal Microbiota of Yellow-Feathered Broilers

Gong

Xiao

Zheng

et al. 2021

Animals

View full text Add to dashboard Cite

This study aimed to evaluate the effects of tributyrin on growth performance, biochemical indices and intestinal microbiota of yellow-feathered broilers. 360 one-day-old chicks were randomly allocated to three treatments with six replicates of 20 chicks each, including a normal control group (NC), an antibiotic group (PC), and a tributyrin (250 mg/kg) group (TB) for 63 days. The results showed that compared with the control, the feed conversion ratio (FCR) in the TB group decreased during the d22 to d42 (p < 0.05) and overall, the final weight and FCR of broilers tended to increase and decrease, respectively. Moreover, the TB group showed the highest creatine concentrations at the entire period (p < 0.05). TB treatment increased the Bacteroidetes relative abundance and decreased Firmicutes. Principal coordinates analysis yielded clear clustering of the three groups. Linear discriminant analysis effect size analysis found seven differentially abundant taxa in the TB group, including several members of Bacteroidedetes. The relative abundance of Eisenbergiella, Phascolarctobacterium, Megasphaera and Intestinimonas increased in tributyrin-treated broilers. Spearman correlation analysis identified a correlation between Eisenbergiella abundance and overall feed efficiency. These results demonstrated that tributyrin could improve the growth performance by modulating blood biochemical indices and the cecal microflora composition of broilers.

show abstract

“…Two hundred and forty 26-day-old Hexi dwarf female broilers were randomly allotted into two experimental groups with similar conditions to those under which commercial farm animals were kept before the first day of the trial. After one week of adaptation, the control group (NC) received a basal diet, while the TB group received the same basal diet supplemented with 1 g/kg of dietary tributyrin [ 20 ] (Jinfulai Technology Development Co., Ltd., Harbin, China). All groups consisted of 6 replicates per treatment and 20 chickens in each replicate.…”

Section: Methodsmentioning

confidence: 99%

Effects of Tributyrin Supplementation on Liver Fat Deposition, Lipid Levels and Lipid Metabolism-Related Gene Expression in Broiler Chickens

Duan

Liu

et al. 2022

Genes

View full text Add to dashboard Cite

The objective of this study was to investigate the effects of tributyrin supplementation on liver fat metabolism in broiler chickens. Two hundred and forty broilers were randomly allocated into two experimental groups (6 replicates per treatment; 20 chickens in each replicate): the control group (CN), which received a basal diet, and the tributyrin group (TB), which received a basal diet supplemented with 1 g/kg of tributyrin. The experimental period lasted 37 days. The results showed that in the liver, broilers supplemented with tributyrin had higher content of high-density lipoprotein cholesterol (HDL-C) (p < 0.05). Liver hepatic lipase (HL), lipoprotein lipase (LPL) and total lipid (TL) activity were significantly lower than in the TB group than that in the NC group. Meanwhile, the diet supplemented with tributyrin had more lipid droplets than the NC group, whereas the TB and NC groups showed no histological abnormalities in the liver. Furthermore, the mRNA expression levels of peroxisome proliferators-activated receptor α (PPARα), proliferators-activated receptor γ (PPARγ), fatty acid synthase (FAS), LPL and adipose triglyceride lipase (ATGL) in the liver were significantly upregulated in the TB group (p < 0.05), while those of the long-chain acyl-CoA-synthetase 1 (ACSL1) mRNA between the TB group and the NC group were not different (p > 0.05). These findings indicated that the diet supplemented with tributyrin could increase fat deposition appropriately by promoting fat synthesis without causing liver tissue damage, which demonstrated that tributyrin can be considered a valid feed additive for broiler chickens.

show abstract

Dietary tributyrin improves reproductive performance, antioxidant capacity, and ovary function of broiler breeders

Cited by 17 publications

References 44 publications

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Effects of Chitosan Oligosaccharide on Production Performance, Egg Quality and Ovarian Function in Laying Hens with Fatty Liver Syndrome

Effects of Dietary Tributyrin on Growth Performance, Biochemical Indices, and Intestinal Microbiota of Yellow-Feathered Broilers

Effects of Tributyrin Supplementation on Liver Fat Deposition, Lipid Levels and Lipid Metabolism-Related Gene Expression in Broiler Chickens

Contact Info

Product

Resources

About