Diethyloxalate as “CO” Source for Palladium‐Catalyzed Ethoxycarbonylation of Bromo‐ and Chloroarene Derivatives

Abstract

Palladium(II)‐catalyzed ethoxycarbonylation of aryl bromides with diethyloxalate oxalate is described. Functionalized aromatic esters can be efficiently synthesized with only 0.65 mol % PdCl2(PPh3)2 catalyst under microwave irradiation and without additional ligand. This method illustrates an inexpensive and operationally simple method for the preparation of aromatic esters.magnified image

Electrochemical Umpolung of Bromide: Transition-Metal-Free Bromination of Indole C–H Bond

“…Aromatic bromides are an important class of compounds, which are commonly utilized as the coupling partner in transition-metal-catalyzed cross-coupling reactions [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. Thus, the development of a synthetic method of arylbromides has attracted tremendous efforts [ 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ].…”