1992
DOI: 10.1097/00006231-199207000-00012
|View full text |Cite
|
Sign up to set email alerts
|

Difference in inhaled aerosol deposition patterns in the lungs due to three different sized aerosols

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0

Year Published

1997
1997
2020
2020

Publication Types

Select...
3
3

Relationship

0
6

Authors

Journals

citations
Cited by 8 publications
(5 citation statements)
references
References 0 publications
0
5
0
Order By: Relevance
“…The real deposition of particles in the human lung when inhaled depends on several factors such as particle concentration in the air, size of particles, and respiratory intensity. Also the site of deposition depends on these factors and at specific ''hot spots'' the total amount of particles deposited may locally become relatively high (Martonen et al 1992a,b;Miki et al 1992;Balásházy et al 2000). A total of 50 mL of test media were added to the particles in the test vessels before exposure during various time periods in a Stuart platform rocker S180 incubator, regulated at a temperature of 37 AE 0.5 8C, with bilinear shaking of 25 cycles per min.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…The real deposition of particles in the human lung when inhaled depends on several factors such as particle concentration in the air, size of particles, and respiratory intensity. Also the site of deposition depends on these factors and at specific ''hot spots'' the total amount of particles deposited may locally become relatively high (Martonen et al 1992a,b;Miki et al 1992;Balásházy et al 2000). A total of 50 mL of test media were added to the particles in the test vessels before exposure during various time periods in a Stuart platform rocker S180 incubator, regulated at a temperature of 37 AE 0.5 8C, with bilinear shaking of 25 cycles per min.…”
Section: Methodsmentioning
confidence: 99%
“…Phosphate buffered saline (PBS, pH 7.4), is a standard physiological solution that mimics the ion strength of human blood serum. It is widely used in the research (Norlin et al 2002) and medical health care community (Hanawa 2004; Okazaki and Gotoh 2005) as a reference test solution for comparison of data under simulated physiological conditions. The composition and pH of the 4 different test media are given in Table 2.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Particle size distribution depends essentially on the design of the nebuliser (Sterk et al 1984;Newman et al 1987;Dennis 1995) and it has been shown that the size distribution of nebulised aerosols is inversely proportional to the operating frequency for the UNs (Newman 1984;Atkins et al 1992) and to the pressure developed upstream from the nebulisers for the JNs (Genicot et al 1995). Although droplet size produced is of paramount importance (Miki et al 1992), it is not the only factor which influences nebulisation efficiency which is also related to factors determined by the subject inhaling the aerosolised drug. The respiratory conditions, i.e.…”
Section: Introductionmentioning
confidence: 99%
“…In vivo human scintigraphic lung imaging studies with inhaled aerosols typically show high local airway deposition of aerosol doses ("hot-spots") in the 'central' ROI and beyond 3,4,5,6 .…”
Section: Introductionmentioning
confidence: 99%