Difference in the distributions between Ca content and the degree of oxidative damage in human hair determined by x-ray imaging

Ito, Atsushi; Inoue, Takafumi; Kawai, Tomomitsu; Taki, Yoshiaki; Inoue, Satoru; Shimizu, Takayuki; Shinohara, Kunio

doi:10.1063/1.4937515

Cited by 2 publications

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“…The Ca distributions were also confirmed by X-ray fluorescence mapping using scanning microbeam X-rays at the Photon Factory (data not shown). The experiments using hair specimens with bleach treatment in our laboratory give similar results [16]. These findings indicate that in determining the Ca contents in hair the detailed distribution of calcium inside hair should be taken into account.…”

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confidence: 74%

Biomedical Application of Soft X-ray Microscopy with Special Reference to Spectromicroscopy

et al. 2016

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Soft X-ray microscopy has great advantages over other types of microscopy on the observation of hydrated specimens at high spatial resolution below 100 nm, and on the elemental and molecular mapping using absorption characteristics. These advantages are particularly suitable for biomedical applications. A possible problem associated with observation of specimens at high spatial resolution in a hydrated environment is described and a strategy to overcome the problem is presented. The latter part of the present report deals with spectromicroscopy to obtain molecular distribution in biological specimens. DNA and protein distributions in isolated nuclei are examined following to the progression of apoptosis at high resolution, and the oxidation product is visualized in human hair in relation to calcium content.

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confidence: 74%

Biomedical Application of Soft X-ray Microscopy with Special Reference to Spectromicroscopy

et al. 2016

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Trace Elements in Hair: Relevance to Air Pollution

Chikawa¹,

Salter²,

Shima³

et al. 2018

Trace Elements - Human Health and Environment

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Elemental concentrations of single hair samples taken from 2003 to 2012 had been evaluated by X-ray fluorescence for the assessment of the relation between calcium and cancer. Early results implied a mechanism linking hair and serum element concentrations with a shift in element levels over time. After 2009, pollution-attributable differences were seen in the levels of Ca, Sr, P, Cl, Br, K, S, elements under renal control by parathyroid hormone (PTH), as well as Cu, Zn, Ti. Especially, hair taken from February to March 2011 showed low [Cu] and [Zn] indicating about half of the normal serum level and often three orders of magnitude higher [Ti] than typical. These specimens also showed higher serum [S] than usual, and except for one patient with PTH-related disease, all the subjects had the normal or lower hair calcium than typical for earlier years. Almost all the subjects showed store-operated Ca channel gating. The pollution era is associated with an increase in hair Na, a decrease in K, and abnormally low P, suggesting a functional deterioration of Na + /K +-ATPase. These results can be attributed to increases in serum Ca and S coincident with breathing the polluted air; the incorporated Ca closes the ion channels of hair matrix cells but may be moved with P to bone, resulting in the abnormal P deficiency, likely producing an ATP shortage in serum. This insufficient ATP supply may result in inactivated molecular pumps and hypokalemia contributing to fatal ventricular fibrillation in patients with myocardial infarction. The pollution increase [S] in serum may be excreted by forming sulfide compounds with Cu and Zn, resulting in Cu deficiency necessary for making elastin to repair damage in blood vessels. The K and Cu deficiencies observed appear to account for the reported increase in infarction mortality after high-pollution days.

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Difference in the distributions between Ca content and the degree of oxidative damage in human hair determined by x-ray imaging

Cited by 2 publications

References 4 publications

Biomedical Application of Soft X-ray Microscopy with Special Reference to Spectromicroscopy

Biomedical Application of Soft X-ray Microscopy with Special Reference to Spectromicroscopy

Trace Elements in Hair: Relevance to Air Pollution

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