Difference of Antioxidative Effect Between Vitamin E and Selenium

Zhu, L.; He, Youping; Piao, Jianhua; Cai, Qiang; Sun, Chenyu; Chang, Jui‐Hsing; Wu, Kang; Cong, Jiahui

doi:10.1007/978-3-0348-7432-8_9

Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications 1992

DOI: 10.1007/978-3-0348-7432-8_9

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Difference of Antioxidative Effect Between Vitamin E and Selenium

L. Zhu

Youping He

Jianhua Piao

et al.

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Cited by 5 publications

(3 citation statements)

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“…Antioxidant defense is achieved by additive or synergistic action of enzymes and antiox-idant nutrients (11,12). Selenium and vitamin E in particular appear to have overlapping and partly compensative functions (13)(14)(15)(16)(17). Therefore, it is conceivable that the relation between selenium status and risk of coronary heart disease is influenced by the status of other antioxidants, as has been observed in an animal experiment (18).…”

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confidence: 98%

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Kardinaal

Kok

Kohlmeier

et al. 1997

American Journal of Epidemiology

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The association between selenium status and risk of acute myocardial infarction was examined in a multicenter case-control study in 10 centers from Europe and Israel in 1991-1992. Selenium in toenails was assessed for 683 nonfatal male cases with first acute myocardial infarction and 729 controls less than 70 years of age. Median toenail selenium content was 0.553 /xg/g for cases and 0.590 jxg/g for controls. After adjustment for age, center, and smoking, the odds ratio for myocardial infarction in the highest quintile of selenium as compared with the lowest was 0.63 (95 percent confidence interval 0.37-1.07, p for trend = 0.08). The observed inverse trend was somewhat stronger when the authors adjusted for vitamin E status (p = 0.05). Analysis stratified for smoking habits showed an inverse association in former smokers (odds ratio for the 75th-25th percentile contrast = 0.63 (95 percent confidence interval 0.43-0.94)), but not in current smokers (odds ratio = 0.97 ( 0.71-1.32)) or in those who had never smoked (odds ratio = 1.55 (0.87-2.76)). Analysis stratified by center showed a significant inverse association between selenium levels and risk of myocardial infarction for Germany (Berlin) only (75th to 25th percentile odds ratio = 0.62 (95 percent confidence interval 0.42-0.91)), which was the center with the lowest selenium levels. It appears that the increased risk of acute myocardial infarction at low levels of selenium intake is largely explained by cigarette smoking; selenium status does not appear to be an important determinant of risk of myocardial infarction at the levels observed in a large part of Europe. Am J Epidemiol 1997;145:373-9. antioxidants; case-control studies; myocardial infarction; selenium Evidence is accumulating that oxidation of low density lipoprotein particles and cytotoxic effects of lipid peroxides enhance the formation of foam cells and atherosclerotic lesions (1, 2). Selenium is part of the enzyme glutathione peroxidase, which plays an important role in the antioxidant defense of the body against the deleterious actions of free radicals and lipid per-

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mentioning

confidence: 98%

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Kardinaal

Kok

Kohlmeier

et al. 1997

American Journal of Epidemiology

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“…At present, the mineralization methods frequently employed for the analysis of biological samples are wet digestion with concentrated acids using either convective systems or microwave ovens (Zhu et al 1992). The main advantage of microwave-assisted pretreatment of samples is the small amount of mineral acids required and reduced production of nitrous vapors.…”

mentioning

confidence: 99%

Assessment of selenium and mercury in biological samples of normal and night blindness children of age groups (3–7) and (8–12) years

Afridi

Kazi

Talpur

et al. 2015

Environ Monit Assess

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The causes of night blindness in children are multifactorial and particular consideration has been given to childhood nutritional deficiency, which is the most common problem found in underdeveloped countries. Such deficiency can result in physiological and pathological processes that in turn influence biological sample composition. This study was designed to compare the levels of selenium (Se) and mercury (Hg) in scalp hair, blood, and urine of night blindness children age ranged (3-7) and (8-12) years of both genders, comparing them to sex- and age-matched controls. A microwave-assisted wet acid digestion procedure was developed as a sample pretreatment for the determination of Se and Hg in biological samples of night blindness children. The proposed method was validated by using conventional wet digestion and certified reference samples of hair, blood, and urine. The Se and Hg in biological samples were measured by electrothermal atomic absorption spectrometry and cold vapor atomic absorption spectrometry, prior to microwave acid digestion, respectively. The concentration of Se was decreased in scalp hair and blood samples of male and female night blindness children while Hg was higher in all biological samples as compared to referent subjects. The Se concentration was inversely associated with the risk of night blindness in both genders. These results add to an increasing body of evidence that Se is a protecting element for night blindness. These data present guidance to clinicians and other professional investigating deficiency of essential micronutrients in biological samples (scalp hair and blood) of night blindness children.

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“…A synergistic antioxidative effect of selenium with vitamin E has been established (23,37). Vitamin E and selenium show different and complementary antioxidative activities in the living cell (38).…”

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confidence: 99%

11‐selenadodecylglyceryl‐1‐ether in lipid autoxidation

Yanishlieva

Raneva

Marinova

et al. 2001

J Americ Oil Chem Soc

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The effect of 11-selenadodecylglyceryl-1-ether (11-SeDGE) at concentrations of 5 × 10 −4 and 1 × 10 −2 M on the autoxidation of sunflower oil with a natural content of 0.06% tocopherols at 100°C and at room temperature in the dark and of pure triacylglycerols of sunflower oil (TGSO) at 100°C was studied. The process was followed by peroxide concentration (peroxide value) determination and by ultraviolet (UV) spectroscopy. It was found that 11-SeDGE acted synergistically with the tocopherols in sunflower oil in a dose-dependent manner to delay oxidation at 100°C. The results from the UV spectra indicated that 11-SeDGE decomposed the initiators of the process, the hydroperoxides, into inactive products. During oxidation of pure TGSO (i.e., depleted of tocopherols) at 100°C, 11-SeDGE retarded the process without a pronounced induction period. At room temperature, 11-SeDGE showed a slight prooxidative effect on sunflower oil oxidation. Taking into account the established prooxidative effect of the two hydroxy groups in a molecule such as 11-SeDGE, it was recommended to study the lipid autoxidation in the presence of selenium compounds that do not contain such prooxidative groups.Paper no. J9693 in JAOCS 78, 691-696 (July 2001).Selenium (Se) is an essential micronutrient that has important biological activities (1-5). It is considered to strengthen the immune system (6) and to be a protective agent against cancer (7-15),human immunodeficiency virus (14,16), and heart diseases (17-19). Therefore, Se-containing compounds are valuable food constituents (5,19-23) and are included as active components in pharmaceuticals (3,4,24,25) and cosmetics (9,26). The concentration of selenium and its biological activity are closely related to the reactive oxygen species (27). That is, the higher the concentration of selenium, the greater its biological activity and the lower the concentration of the reactive oxygen species.Sodium selenate, sodium selenite, selenourea, and selenomethionine display an interesting antioxidant capacity because these derivatives catalyze the disproportionation of the superoxide ion (28). Selenium is a part of the antioxidative enzyme selenoglutathione oxidase, which inactivates free radicals and other oxidants, particularly hydrogen peroxide (29). The biological activity of selenium compounds is related to their antioxidant properties in lipid oxidation in membranes in vitro and in vivo (2)(3)(4)12,18,20,(30)(31)(32)(33)(34)(35)(36). A synergistic antioxidative effect of selenium with vitamin E has been established (23,37). Vitamin E and selenium show different and complementary antioxidative activities in the living cell (38).In general, the organoselenium compounds are more biologically active and less toxic than inorganic selenium (39). Already 50 yr ago, Denison and Condit (40) reported on the good antioxidant effectiveness of fatty alcohol selenides, especially didodecyl selenide, in lubricating oils.Data concerning the effect of selenium compounds on the autoxidation of lipids in vitro are sparse. ...

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Difference of Antioxidative Effect Between Vitamin E and Selenium

Cited by 5 publications

References 5 publications

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Assessment of selenium and mercury in biological samples of normal and night blindness children of age groups (3–7) and (8–12) years

11‐selenadodecylglyceryl‐1‐ether in lipid autoxidation

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