Differences by age in the obesity paradox in severe burns

Lin, Jian-Chang; Zheng, Jianjun; Wu, Guohua; Chen, Zhaohong; Chen, Xiao; Jiang, Qiong

doi:10.1016/j.burns.2022.02.004

Cited by 4 publications

(12 citation statements)

References 31 publications

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“…Our result was not in line with the results of a cross‐sectional study (2022) that investigated whether the obesity paradox existed in severe burn patients stratified by age. Results of this study suggested that mortality decreased by 17.8% when BMI increased by 1 kg/m 2 in the patients in the age group between 18 and 65 years old 86 . This finding was not seen in the age group over 65 years old 86 .…”

Section: Discussionmentioning

confidence: 56%

“…86 This finding was not seen in the age group over 65 years old. 86 Another study also revealed that for every increase of 1 kg/m 2 in F I G U R E 3 Odds ratio of mortality in abnormal to normal BMI patients. BMI, mortality decreased by 0.14 in burn victims, and it was statistically significant.…”

Section: Discussionmentioning

confidence: 81%

“…As shown in Figure 2, all studies 78,79,83–86 were of high quality. Also, one study 83 did not report the limitations and funding sources or conflict of interests of the research.…”

Section: Resultsmentioning

confidence: 94%

“…Following a thorough review of the full texts of the publications, 41 studies were disregarded due to subpar design or results, and 19 studies were disregarded due to inadequate data. In the end, six articles 78 , 79 , 83 , 84 , 85 , 86 were included in this systematic review and meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…As mentioned in Table 1, a total of 16 154 burn patients participated in six studies. 78,79,[83][84][85][86] Their mean age was…”

Section: Study Characteristicsmentioning

confidence: 99%

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Relationship between body mass index and mortality of burns patients: A systematic review and meta‐analysis

Al‐dolaimy,

Abdul‐Reda Hussein,

Hadi Kzar

et al. 2023

International Wound Journal

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This systematic review and meta‐analysis aimed to evaluate the relationship between body mass index (BMI) and mortality of burn patients. A comprehensive, systematic search was conducted in different international electronic databases, such as Scopus, PubMed, Web of Science and Persian electronic databases such as Iranmedex, and Scientific Information Database (SID) using keywords extracted from Medical Subject Headings such as “Body mass index”, “Burns” and “Mortality” from the earliest to the April 1, 2023. The quality of the studies included in this systematic review was evaluated using the appraisal tool for cross‐sectional studies (AXIS tool). Finally, six articles were included in this systematic review and meta‐analysis. A total of 16 154 burn patients participated in six studies. Their mean age was 46.32 (SD = 1.99). Of the participants, 71.7% were males. The mean length of hospitalization was 18.80 (SD = 8.08) days, and the average TBSA in burn patients was 38.32 (SD = 2.79) %. Also, the average BMI in burn patients was 27.10 (SD = 1.75). Results found mortality in patients with abnormal BMI (overweight to morbidity BMI) was 0.19 more than normal BMI (ES: 1.19, 95%CI: 0.76–1.87, Z = 0.75, I2: 71.8%, p = 0.45). Results of linear dose–response showed each 5 kg/m2 increase in BMI was associated with a 5% increase in mortality that was marginally significant (ES: 1.05, 95%CI: 1.00–1.11, Z = 1.99, I2: 22.2%, p = 0.047). There was a non‐linear relationship between levels of BMI and mortality (Prob > χ2 = 0.02). There was an increase in mortality from percentile 10 to 50, although it was not significant (Correlational coefficient: 0.01, p = 0.85). Also, there was an increase in mortality rate from percentile 50 to 90 that was statistically significant (correlational coefficient: 0.06, p = 0.047). Finally, the results of the study indicated BMI can increase the chance of mortality by 0.19, although it was not significant. As a result, more studies are needed to better judge the relationship between BMI and mortality in burn victims.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 81%

“…As shown in Figure 2, all studies 78,79,83–86 were of high quality. Also, one study 83 did not report the limitations and funding sources or conflict of interests of the research.…”

Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

“…As mentioned in Table 1, a total of 16 154 burn patients participated in six studies. 78,79,[83][84][85][86] Their mean age was…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Relationship between body mass index and mortality of burns patients: A systematic review and meta‐analysis

Al‐dolaimy,

Abdul‐Reda Hussein,

Hadi Kzar

et al. 2023

International Wound Journal

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Burn injury in obesity: Examination of the Burn Care Quality Platform’s (BCQP) available data on obese patients to determine burn-related outcomes

Kelly,

Mathew,

Carney

et al. 2025

Burns

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Association of waist circumference and BMI with premature death in young and middle-aged population

Hu,

Han,

Chen

et al. 2024

Front. Public Health

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IntroductionPremature death is a global health indicator, significantly impacted by obesity, especially in young and middle-aged population. Both body mass index (BMI) and waist circumference (WC) assess obesity, with WC specifically indicating central obesity and showing a stronger relationship with mortality. However, despite known associations between BMI and premature death, as well as the well-recognized correlation between WC and adverse health outcomes, the specific relationship between WC and premature death remains unclear. Therefore, focusing on young and middle-aged individuals, this study aimed to reliably estimate independent and combined associations between WC, BMI and premature death, thereby providing causal evidence to support strategies for obesity management.MethodsThis study involved 49,217 subjects aged 18–50 years in the United States from 1999 to 2018 National Health and Nutrition Examination Survey (NHANES). Independent and combined associations between WC and BMI with premature death across sex and age stratum were examined by Cox regression. Survey weighting and inverse probability weighting (IPW) were further considered to control selection and confounding bias. Robustness assessment has been conducted on both NHANES and China Health and Retirement Longitudinal Study (CHARLS) data.ResultsA linear and positive relationship between WC and all-cause premature death was found in both males and females, with adjusted HRs of 1.019 (95%CI = 1.004–1.034) and 1.065 (95%CI = 1.039–1.091), respectively. Nonlinear relationships were found with respect to BMI and all-cause premature death. For females aged 36–50 with a BMI below 28.6 kg/m2, the risk of premature death decreased as BMI increased, indicated by adjusted HRs of 0.856 (95%CI = 0.790–0.927). Joint analysis showed among people living with obesity, a larger WC increased premature death risk (HR = 1.924, 95%CI = 1.444–2.564).DiscussionWC and BMI exhibited prominent associations with premature death in young and middle-aged population. Maintaining an appropriate WC and BMI bears significant implications for preventing premature death.

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Differences by age in the obesity paradox in severe burns

Cited by 4 publications

References 31 publications

Relationship between body mass index and mortality of burns patients: A systematic review and meta‐analysis

Relationship between body mass index and mortality of burns patients: A systematic review and meta‐analysis

Burn injury in obesity: Examination of the Burn Care Quality Platform’s (BCQP) available data on obese patients to determine burn-related outcomes

Association of waist circumference and BMI with premature death in young and middle-aged population

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