Differences in ABCA1 R219K Polymorphisms and Serum Indexes in Alzheimer and Parkinson Diseases in Northern China

Ya, Lagai; Lu, Zuneng

doi:10.12659/msm.903636

Cited by 17 publications

(17 citation statements)

References 33 publications

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“…TAG levels are decreased in serum and plasma of (male) PD patients [222,223,229,230,231,232,233], even before diagnosis [234], and higher serum TAG is associated with reduced risk of idiopathic PD [235]. However, other studies have found no differences in blood TAG levels of PD patients and controls [236,237]. In the primary visual cortex of PD patients, the levels of TAG are decreased [225].…”

Section: Glycerolipidsmentioning

confidence: 99%

“…The main biological role of HDL is in cargo transport, in particular of lipids and proteins, but it is now also known to bring miRNAs to recipient cells [535]. Lower plasma HDL and ApoA1 levels have been associated with earlier PD onset [536] and higher PD risk [237,537,538,539], and HDL levels are positively correlated with disease duration [540]. Plasma levels of HDL-cholesterol are lower [229,385,541] or not different [230,233,446,447,457] in PD patients compared to controls.…”

Section: Lipoproteinsmentioning

confidence: 99%

“…High LDL-cholesterol levels in plasma are protective for PD and associated with preserved executive and fine motor functions in PD [452,455,457,542], while lower LDL-cholesterol levels are associated with higher PD risk [229,445,446,447,500,543,544]. One study reported that plasma LDL levels are not different between PD patients and controls [237]. A number of other studies have reported no difference in baseline LDL-cholesterol [230,497], and two meta-analyses have found no association [238,496].…”

Section: Lipoproteinsmentioning

confidence: 99%

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The Role of Lipids in Parkinson’s Disease

Xicoy

Wieringa

Martens

2019

Cells

189

161

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Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and microgliosis. During the past decades multiple cellular pathways have been associated with PD pathology (i.e., oxidative stress, endosomal-lysosomal dysfunction, endoplasmic reticulum stress, and immune response), yet disease-modifying treatments are not available. We have recently used genetic data from familial and sporadic cases in an unbiased approach to build a molecular landscape for PD, revealing lipids as central players in this disease. Here we extensively review the current knowledge concerning the involvement of various subclasses of fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and lipoproteins in PD pathogenesis. Our review corroborates a central role for most lipid classes, but the available information is fragmented, not always reproducible, and sometimes differs by sex, age or PD etiology of the patients. This hinders drawing firm conclusions about causal or associative effects of dietary lipids or defects in specific steps of lipid metabolism in PD. Future technological advances in lipidomics and additional systematic studies on lipid species from PD patient material may improve this situation and lead to a better appreciation of the significance of lipids for this devastating disease.

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Section: Glycerolipidsmentioning

confidence: 99%

Section: Lipoproteinsmentioning

confidence: 99%

Section: Lipoproteinsmentioning

confidence: 99%

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The Role of Lipids in Parkinson’s Disease

Xicoy

Wieringa

Martens

2019

Cells

189

161

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“…The density and size of these particles are similar to those of plasma HDL [ 148 ]. ABCA1 contributes to cholesterol homeostasis and participates in the pathophysiology of neurological diseases involving the accumulation of proteins in brain cells, such as traumatic brain injury, stroke sequelae, Parkinson’s disease, and Alzheimer’s disease (AD) [ 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 ].…”

Section: Abca1 In Neurological Diseasementioning

confidence: 99%

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

Jacobo-Albavera

Domínguez‐Pérez

Medina-Leyte

et al. 2021

IJMS

103

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Cholesterol homeostasis is essential in normal physiology of all cells. One of several proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein widely expressed in many tissues. One of its main functions is the efflux of intracellular free cholesterol and phospholipids across the plasma membrane to combine with apolipoproteins, mainly apolipoprotein A-I (Apo A-I), forming nascent high-density lipoprotein-cholesterol (HDL-C) particles, the first step of reverse cholesterol transport (RCT). In addition, ABCA1 regulates cholesterol and phospholipid content in the plasma membrane affecting lipid rafts, microparticle (MP) formation and cell signaling. Thus, it is not surprising that impaired ABCA1 function and altered cholesterol homeostasis may affect many different organs and is involved in the pathophysiology of a broad array of diseases. This review describes evidence obtained from animal models, human studies and genetic variation explaining how ABCA1 is involved in dyslipidemia, coronary heart disease (CHD), type 2 diabetes (T2D), thrombosis, neurological disorders, age-related macular degeneration (AMD), glaucoma, viral infections and in cancer progression.

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“…The meta-analysis showed no signi cant difference in the TC level between the RR genotype population and the K allele carriers in the random model, and signi cant heterogeneity was found among all studies. After four outliers (Abellán [93] data1, Ya [105] data1, 2 and 3) detected by the meta and metafor packages were removed (Fig. S7-1 and 2), a consistent result was obtained (SMD = 0.01 mmol/L, 95%CI:-0.06 ~ 0.08, z = 0.20, P = 0.846; I 2 = 88.37%, Q = 782.18, df = 91, P < 0.001.…”

Section: Meta-analysis For Genetic Variant R219k and Tcmentioning

confidence: 99%

Association Between ABCA1 (R219K) Polymorphism and Lipid Profiles: A Meta-Analysis

Shi¹,

Tian²,

Wu³

et al. 2020

Preprint

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Background Conflicting evidence was found about the relationship between lipid profiles and R219K in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. A meta-analysis was conducted to assess the effect of R219K on lipid level. Methods Multi-database literature search was performed in accordance with PRISMA guidelines. The effect of each study was expressed by standard mean difference (SMD) and 95% confidence interval and pooled by meta-analysis in a random-effects model. Sub-group and meta-regression analyses were also conducted to explore potential heterogeneity sources. Results Overall pooled effect showed that individuals with RR genotype had significantly lower HDLC level (SMD = -0.17 mmol/L, 95% CI: -0.22 ~ -0.12, z = -6.39, P < 0.001) than those with K allele. However, this effect mainly presented in Asians (SMD = -0.24 mmol/L, 95% CI: -0.32 ~ -0.17, z = 6.60, P < 0.001) rather than Caucasian populations, and the difference was significant (Q = 5.20, df = 1, P = 0.02). The relationship between R219K polymorphism and LDLC, TC, and TG levels was not determined. Conclusions R219K polymorphism in the ABCA1 gene was associated with HDLC level in Asian populations in the present meta-analysis. This correlation was not substantially affected by the age, gender or health condition of individuals.

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Differences in ABCA1 R219K Polymorphisms and Serum Indexes in Alzheimer and Parkinson Diseases in Northern China

Cited by 17 publications

References 33 publications

The Role of Lipids in Parkinson’s Disease

The Role of Lipids in Parkinson’s Disease

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

Association Between ABCA1 (R219K) Polymorphism and Lipid Profiles: A Meta-Analysis

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