Differences in Baseline Nasal Secretions Between Chronic Fatigue Syndrome (CFS) and Control Subjects

Naranch, Kristina; Repka-Ramirez, S.; Park, Y. J.; Velarde, A.; Finnegan, Rebecca; Murray, Joseph C.; Pheiffer, A.; Hwang, Eung Soo; Clauw, Daniel J.; Baraniuk, James N.

doi:10.1300/j092v10n01_02

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…As indicated in a previous report [25], proteins identified in the first series of NLF specimens have plasma origin while those of the second series are secreted from glands. A unified list of proteins tabulated by name, NCBI accession number, number of subjects in which each single protein was found, and their origin has been reported in Table 3, where a total of 111 proteins, 42 of which (underlined) have never been identified before in NLF, are listed.…”

Section: Nlf Profilesupporting

confidence: 53%

Identification of human nasal mucous proteins using proteomics

Casado¹,

Pannell²,

Iadarola³

et al. 2005

Proteomics

113

111

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The determination of possible biomarkers in nasal secretion of healthy subjects can have a role in early diagnosis of diseases such as rhinosinusitis. For this purpose, nasal lavage fluids (NLFs) from ten volunteers, collected before and after they had been submitted to nasal provocations, were investigated. Separation and analysis of proteins present in this complex matrix was performed using a capillary liquid chromatography-electrospray-quadrupole-time of flight mass spectrometry equipment. From among a total of 111 proteins found (89 known and two unknown proteins), 42 of which had never been previously described in this fluid, such as Deleted in Malignant Brain Tumors 1 isoform a precursors, and cytoskeletal proteins were identified with high statistical score. Three proteins of palate lung nasal epithelial clone (PLUNC) family: SPLUNC1, LPLUNC1, and LPLUNC2 were identified. Proteins involved in innate (27%) and acquired immunity (21%) systems were major components of NLF. Cellular (52% of all proteins identified) such as cytoskeletal (33%), functional (15%), and regulatory (4%) proteins, normally present in the nasal cavity, have also been identified. The proteomic approach presented here allowed us to identify the proteins involved in acquired and innate immune response in the nose against microbial infections and unclean inhaled air.

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Section: Nlf Profilesupporting

confidence: 53%

Identification of human nasal mucous proteins using proteomics

Casado¹,

Pannell²,

Iadarola³

et al. 2005

Proteomics

113

111

View full text Add to dashboard Cite

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Neuropathology in Rhinosinusitis

Baraniuk

Petrie

et al. 2005

Am J Respir Crit Care Med

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Pathophysiologic differences in neural responses to hypertonic saline (HTS) were investigated in subjects with acute sinusitis (n = 25), subjects with chronic fatigue syndrome (CFS) with nonallergic rhinitis (n = 14), subjects with active allergic rhinitis (AR; n = 17), and normal (n = 20) subjects. Increasing strengths of HTS were sprayed into their nostrils at 5-minute intervals. Sensations of nasal pain, blockage, and drip increased with concentration and were significantly elevated above normal. These parallels suggested activation of similar subsets of afferent neurons. Urea and lysozyme secretion were dose dependent in all groups, suggesting that serous cell exocytosis was one source of urea after neural stimulation. Only AR and normal groups had mucin dose responses and correlations between symptoms and lysozyme secretion (R(2) = 0.12-0.23). The lysozyme dose responses may represent axon responses in these groups. The neurogenic stimulus did not alter albumin (vascular) exudation in any group. Albumin and mucin concentrations were correlated in sinusitis, suggesting that nonneurogenic factors predominated in sinusitis mucous hypersecretion. CFS had neural hypersensitivity (pain) but reduced serous cell secretion. HTS nasal provocations identified significant, unique patterns of neural and mucosal dysregulation in each rhinosinusitis syndrome.

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The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome

Huitsing,

Tritsch,

Arias

et al. 2024

Mol Med

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals also report suffering from rhinitis, dry eyes and a sore throat. Mucin proteins are responsible for contributing to the formation of mucosal membranes throughout the body. These mucosal pathways contribute to the body’s defense mechanisms involving pathogenic onset. When compromised by pathogens the epithelium releases numerous cytokines and enters a prolonged state of inflammation to eradicate any particular infection. Based on genetic analysis, and computational theory and modeling we hypothesize that mucin protein dysfunction may contribute to ME/CFS symptoms due to the inability to form adequate mucosal layers throughout the body, especially in the ocular and otolaryngological pathways leading to low grade chronic inflammation and the exacerbation of symptoms.

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Differences in Baseline Nasal Secretions Between Chronic Fatigue Syndrome (CFS) and Control Subjects

Cited by 4 publications

References 10 publications

Identification of human nasal mucous proteins using proteomics

Identification of human nasal mucous proteins using proteomics

Neuropathology in Rhinosinusitis

The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome

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