Differences in bone accrual over one year in young girls with obesity compared to Normal weight controls

Singhal, Vibha; Kaur, Snimarjot; Haidar, Lea Abou; Lee, Hang; Bredella, Miriam A.; Misra, Madhusmita

doi:10.1016/j.bone.2023.116757

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been previously reported that body lipid percentage is positively correlated with reduced bone mass and that excess lipid causes a decrease in BMD and bone mineral content [ 22 , 23 ]. It has also been demonstrated that excess adipose tissue affects bone metabolism and that obesity reduces osteoblast differentiation and bone formation while increasing adipogenesis.…”

Section: Discussionmentioning

confidence: 99%

Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Cheng

2023

J Orthop Surg Res

View full text Add to dashboard Cite

Introduction In the aging process of the body, in addition to changes in fat and muscle content, there is also bone loss, implying the possibility of a strong muscle–bone–lipid link. In this study, we initially investigated the relationship between lumbar BMD and low muscle mass and the relationship between “muscle–bone–lipid.” Methods The datasets from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 were used in a cross-sectional investigation. BMD and appendicular skeletal muscle (ASM) were measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by body mass index (BMI) as a marker of sarcopenia. Weighted multivariate regression and logistic regression analysis were used to explore the independent relationship between lumbar BMD and sarcopenia. Fitted smoothing curves and threshold effect analysis were used to describe the nonlinear relationship. Result In 8386 participants with ages 20–59 years, there was a negative association between lumbar BMD and sarcopenia. In the fully adjusted model, the risk of developing sarcopenia decreased by 93% for each 1-unit increase in lumbar BMD (OR = 0.07, 95%CI 0.03–0.20). The risk of sarcopenia was 58% lower in participants in the highest quartile of lumbar BMD than in those in the lowest quartile (OR = 0.42, 95%CI 0.27–0.64). This negative association was more pronounced in the population of women with BMI ≥ 25. Conclusion Our findings suggest that lumbar BMD is negatively associated with sarcopenia in US adults. The dynamic balance between “muscle–bone–lipid” is likely to be related to the pathogenesis of bone loss.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Cheng

2023

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

Bone mass accrual in children

Rodrick,

Kindler

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Purpose of review Bone accrual during childhood and adolescence is critical for the attainment of peak bone mass and is a major contributing factor towards osteoporosis in later life. Bone mass accrual is influenced by nonmodifiable factors, such as genetics, sex, race, ethnicity, and puberty, as well as modifiable factors, such as physical activity and diet. Recent progress in bone imaging has allowed clinicians and researchers to better measure the morphology, density, and strength of the growing skeleton, thereby encompassing key characteristics of peak bone strength. In this review, the patterning of bone accrual and contributors to these changes will be described, as well as new techniques assessing bone mass and strength in pediatric research and clinical settings. Recent findings This review discusses factors influencing peak bone mass attainment and techniques used to assess the human skeleton. Summary The rate of bone accrual and the magnitude of peak bone mass attainment occurs in specific patterns varying by sex, race, ethnicity, longitudinal growth, and body composition. Physical activity, diet, and nutritional status impact these processes. There is a need for longitudinal studies utilizing novel imaging modalities to unveil factors involved in the attainment and maintenance of peak bone strength.

show abstract

Differences in bone accrual over one year in young girls with obesity compared to Normal weight controls

Cited by 2 publications

References 28 publications

Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Correlation between bone mineral density and sarcopenia in US adults: a population-based study

Bone mass accrual in children

Contact Info

Product

Resources

About