Differences in clinical and laboratory characteristics and disease severity between children and adults with dengue virus infection in Taiwan, 2002

Wang, Chin‐Chou; Lee, Ing-Kit; Su, Mu-Chun; Lin, Hung‐I; Huang, Yi‐Chuan; Liu, Shih-Feng; Wu, Chen-Hsuan; Lin, Meng-Chih

doi:10.1016/j.trstmh.2009.04.024

Cited by 66 publications

(60 citation statements)

References 23 publications

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“…Out of 26 positive cases, 12 were males and 14 were females. This data is consistent with the previous reports suggesting no difference, a male excess, or a female excess in dengue patient populations [36][37][38][39][40]. Bhaskar et al [30] also found no difference in male to female ratio in an observational study in Chennai, south India [41].…”

Section: Discussionsupporting

confidence: 92%

Serotyping of Dengue Virus from Deadly Outbreaks of Pakistan

Waqar¹

2016

JHVRV

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Dengue Dengue virus (DENV) belonging to the family Flaviviridae consists of 4 serotypes (DEN-1, 2, 3 & 4) causing severe illnesses like dengue fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Dengue fever has become an emerging disease in Pakistan during the past 5-7 years with an increase in the number of cases every year since 2006. The current study aimed at identifying the serotypes of dengue virus involved in 2011 outbreak of Pakistan. Samples were collected from all provinces of Pakistan. Patients were confirmed in the hospital by antibody captured Enzyme linked immunosorbent assay (ELISA). These ELISA positive serum samples were inoculated on HeLa cell line to raise the viral titer of dengue virus and then RT-PCR was done for serotyping of dengue virus. Initially D1, D2 primers were tried for serotyping of dengue virus but poor results were obtained.Then serotype specific primers were designed having equal fragment length targeting NS1 gene. This approach was successful in serotyping of dengue virus from Pakistani population. On Real time RT-PCR, Dengue virus (DENV) was detected in 43.33% (n=26) patients out of 60 analyzed samples. Among 26 positive cases, 76.9% (n=20) were children and 23.1% (n=6) were adults and 46.1% (n=12) were male and 53.8 % (n=14) were females. ELISA results of 26 PCR positive cases show that 53.8% (n=14) were positive for IgM, 15.4 % (n=4) were positive for IgG and 30.8 % (n=8) were positive for both IgG and IgM. In this study DEN-2 was detected in 13.3% (n=8) patients, DEN-3 was detected in 16.67% (n=10) patients and DEN-2 & DEN-3 coinfection was detected in 13.3% (n=8) patients. We did not detected DEN-1 & DEN-4 in 2011 outbreak of Pakistan in 60 analyzed samples. By this study we can conclude that DEN-2 and DEN-3 were the main serotypes involved in 2011 outbreaks in Pakistan.

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Section: Discussionsupporting

confidence: 92%

Serotyping of Dengue Virus from Deadly Outbreaks of Pakistan

Waqar¹

2016

JHVRV

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“…Además del compromiso hepático, se ha descrito el de los sistemas nervioso central y cardiovascular (33,34), sin embargo, en ningún paciente de este estudio se registraron estas complicaciones, lo cual coincide con lo reportado en otras series en ancianos (19,21,35).…”

Section: Discussionunclassified

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Rosso¹,

Vanegas

Rodríguez

et al. 2016

biomedica

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Contribución de los autores:Róbinson Pacheco y Fernando Rosso: desarrollo de la idea, diseño del estudio y revisión crítica del contenido Sarita Rodríguez: creación de la base de datos, análisis de la información, revisión crítica del contenido Sara Vanegas: revisión de la literatura, diseño del estudio, recolección de datos y análisis de la información Todos los autores participaron en la redacción del manuscrito.Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia Introducción. Hay pocas series de casos publicadas sobre la prevalencia y el curso clínico del dengue en adultos mayores con síndrome febril, habitantes en zonas endémicas para la infección. Se cree que tales casos presentan una baja prevalencia pero revisten mayor gravedad, y más complicaciones y mortalidad. Objetivos. Describir la prevalencia y el curso clínico del dengue en adultos mayores atendidos por síndrome febril agudo en un hospital de alta complejidad de una zona endémica de la enfermedad. Introduction: Little is known about the prevalence and clinical course of dengue infection in elderly patients living in endemic areas; it is presumed that there is a lower prevalence but higher severity, complications and mortality. Objective: To describe the prevalence and clinical course of dengue infection in elderly patients who were admitted to a referral care center for infectious diseases in an endemic region. Materials and methods:We conducted an observational and descriptive study between 2011 and 2014, using a cohort of elderly patients with serological diagnosis of dengue.Results: A total of 235 febrile elderly patients were assessed, of which 43 patients (18.3%) were found to have dengue. The median age was 71 years; 48.7% were female, and 89% of patients had at least one comorbid condition. According to the serological tests, 51.4% of cases were positive for NS1 Ag, 27% for IgM and 54.1% for IgG, while 64.8% were secondary infections. Dengue was diagnosed in 13 patients (35%), dengue with warning signs in 16 cases (43%), and severe dengue in 8 cases (22%). Nearly 56.7% of patients were admitted to hospital and 21.6%, to the intensive care unit. None died. 180Biomédica 2016;36(Supl.2):179-86 Rosso F, Pacheco R, Rodríguez S, Vanegas S Conclusion: We found dengue infection to be more frequent than expected in this sample of elderly patients, due to acute febrile syndrome. Elderly patients also required higher rate of hospitalization and had more complications, however there were no deaths due to good management.

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“…26 Another study showed numerous acute clinical findings more often in Vietnamese adults than children, including arthralgia, myalgia, upper gastrointestional bleeding, abdominal pain, thrombocytopenia, and elevated transaminases. 27 Finally, a study from Singapore that evaluated non-acute symptoms such as fatigue 2 months after first detection of DENV infection found a greater proportion in older subjects as compared with younger subjects.…”

Section: Discussionmentioning

confidence: 99%

Occurrence and Correlates of Symptom Persistence Following Acute Dengue Fever in Peru

Halsey¹,

Williams²,

Laguna-Torres³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue virus (DENV) infection causes an acute febrile illness generally considered to result in either complete recovery or death. Some reviews describe persistent symptoms after the febrile phase, although empirical data supporting this phenomenon is scarce. We evaluated symptom persistence in acute febrile DENV-infected and DENVnegative (controls) individuals from Peru. Self-reported solicited symptoms were evaluated at an acute and a follow-up visit, occurring 10-60 days after symptom onset. Rate of persistence of at least one symptom was 7.7% and 10.5% for DENV infected and control subjects, respectively (P 0.01). The DENV-infected individuals had lower rates of persistent respiratory symptoms, gastrointestinal symptoms, headache, and fatigue, but higher rates of persistent rash compared with controls. Older age and female gender were positively associated with symptom persistence. As dengue cases continue to increase annually, even a relatively low frequency of persistent symptoms may represent a considerable worldwide morbidity burden.

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Differences in clinical and laboratory characteristics and disease severity between children and adults with dengue virus infection in Taiwan, 2002

Cited by 66 publications

References 23 publications

Serotyping of Dengue Virus from Deadly Outbreaks of Pakistan

Serotyping of Dengue Virus from Deadly Outbreaks of Pakistan

Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

Occurrence and Correlates of Symptom Persistence Following Acute Dengue Fever in Peru

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