Differences in Clinical and Laboratory Diagnostic Characteristics of Penicilliosis Marneffei in Human Immunodeficiency Virus (HIV)- and Non-HIV-Infected Patients

Abstract

We compared the clinical and laboratory features of human immunodeficiency virus (HIV)- and non-HIV-infected patients with penicilliosis marneffei. HIV-infected patients had a higher incidence of fungemia. A total of 85.7% of the HIV-negative patients had underlying diseases including hematologic malignancies or had received therapy with corticosteroids or cytotoxic agents. By a Penicillium marneffei -specific mannoprotein Mp1p enzyme-linked immunosorbent assay, serum antigen titers were found to be higher in HIV-positive patients, whereas serum antibody levels were found to be higher in HIV-negative patients.

Penicillium marneffei fungaemia in an allogeneic bone marrow transplant recipient

“…In our previous study, the classical picture of change in antigen and antibody titres for primary infection was observed, in that Mp1p antigenaemia appeared before the appearance of Mp1p antibody. 10 In contrast to what was observed in the previous study, the Mp1p antibody became detectable 4 days before the blood culture was positive for P. marneffei and 9 days before the presence of Mp1p antigenaemia. We speculate that this was due to past P. marneffei infection and memory immunity in the patient.…”

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

“…Isolated cases have been reported for patients who had traveled to areas of endemicity and returned home to Western countries (22,312,378). It has also been reported for patients with deficiencies in cellular immunity and HIV infection and for patients receiving steroids or other forms of immunosuppressive therapy (82,365,378,400).…”

Parietal Lobe Abscess Resulting from Penicillium Marneffei Infection in an Immunocompetent Nigerian: Case Report and Review of Literature

“…Mucocutaneous, oral, and facial manifestations that have been reported in patients with P. marneffei infection 25 were absent in this patient. Most such lesions are molluscum contagiosum-like umbilicated papules mainly distributed over the face and upper trunk 26 .…”