Differences in clinicopathological characteristics and computed tomography findings between signet ring cell carcinoma and nonsignet ring cell carcinoma in early and advanced gastric cancer

Abstract

Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics. SRC's clinicopathological characteristics and prognosis are still controversial. Our study is to describe the clinicopathological features and multidetector computed tomography (MDCT) findings of patients with SRC of the stomach in comparison with nonsignet ring cell adenocarcinoma (NSRC). We retrospectively analyzed data from 241 patients who had undergone curative gastrectomy, including 62 SRC and 179 NSRC. Clinicopathological outcomes and MDCT findings were evaluated, and we investigated whether these variables were correlated with histopathological type. In early gastric carcinoma, patients with SRC were younger (50.2 vs. 60.2 years; P = 0.000) and more likely to be observed in the middle and lower third stomach (P = 0.010). Early SRC had a tendency to be confined to the mucosa (82.1%). There were significant differences in degree of enhancement between early SRC and NSRC on MDCT imaging (P < 0.001). In advanced gastric carcinoma, SRC was more likely to be stage T3‐4 (100%). SRC patients had thicker tumors (P = 0.001) and a higher frequency of diffusely infiltrative gross appearance (P < 0.001). SRC was more likely to have high‐degree contrast enhancement than were NSRC (P = 0.001). The maximal diameter of SRC tumor on MDCT imaging correlated with lymph node metastasis (sensitivity 93.9%, specificity 74.1%) and serosal invasion (sensitivity 89.5%, specificity 78.0%) of SRC. In conclusion, SRC differs significantly from NSRC in clinicopathological features at presentation. MDCT could help differentiate advanced gastric SRC from NSRC based on the thickened stomach wall, high‐degree contrast enhancement, and a higher frequency of diffusely infiltrative gross appearance, particularly in combination.

Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells

“…Gastric cancer is a common malignant tumor that originates in the gastric mucosal epithelium [1]. Gastric cancer can be further classified according to the disease site, which includes gastric cardia cancer, gastric cancer, and gastric antrum cancer [2]. Recent epidemiological data have indicated that there are about 951,000 new cases of gastric cancer around the world and about 723,000 deaths due to gastric cancer, thereby ranking gastric cancer as the fifth most common and third most malignant tumor with the highest mortality rate [3].…”

“…For instance, tumor recurrence has been reported in half of the patients who undergo surgery [11]. In addition, chemotherapy, which induces tumor cell cytotoxicity and eventually death [12], has not significantly improved the overall survival of patients with gastric cancer because of poor selectivity and toxicity [2,10,13,14]. Thus, the traditional treatment schemes for gastric cancer do not meet clinical needs, and the development of novel treatment methods is imperative [15].…”

Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis

“…Metabolism in tumours plays a key role in cellular logistics for rapid proliferation, maintenance of redox homeostasis and in epigenetics and reprogramming [28]. In recent years, there have been many metabolomic studies on GC and reported various metabolites related to GC [29–31]. As a result, the perturbed pathways resulting from the metabolomic analysis of GC were similar, consistently showing a metabolism disorder of amino acids, lipids, and glycolysis in Figure 8.…”

Poorly differentiated is more significant than signet ring cell component for lymph node metastasis in mixed-type early gastric cancer: a retrospective study from a large-volume hospital

“…Generally, undifferentiated cancer consists of poorly differentiated cancer and signet ring cell cancer. Many studies have reported that early SRC type tended to be confined to the mucosal layer and had a lower LNM rate and a higher 5-year survival rate than the non-SRC type [21][22][23]. On the contrary, the Poorly-D type is more likely to invade the submucosal layer, which may contribute to LNM.…”