Differences in DNA-guanine alkylation between male Sprague-Dawley rats and Syrian hamsters following exposure to a single dose of pancreatic nitrosamine carcinogens

Kokkinakis, Demetrius M.

doi:10.1021/tx00014a011

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Further NDPA analogues were studied in rats and hamsters. N-nitroso-bis(2-oxopropyl)amine generated N7-Me-Gua and O 6 -Me-Gua and N-nitroso-bis(2-oxopropyl)amine and N-nitroso-(2-hydroxypropyl)-(2-oxopropylamine) produced N7-2hydroxypropylguanine (Kokkinakis, 1990(Kokkinakis, , 1991.…”

Section: Dna Adduct Formationmentioning

confidence: 99%

Risk assessment of N‐nitrosamines in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2023

EFS2

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EFSA was asked for a scientific opinion on the risks to public health related to the presence of Nnitrosamines (N-NAs) in food. The risk assessment was confined to those 10 carcinogenic N-NAs occurring in food (TCNAs), i.e. NDMA, NMEA, NDEA, NDPA, NDBA, NMA, NSAR, NMOR, NPIP and NPYR. N-NAs are genotoxic and induce liver tumours in rodents. The in vivo data available to derive potency factors are limited, and therefore, equal potency of TCNAs was assumed. The lower confidence limit of the benchmark dose at 10% (BMDL 10 ) was 10 μg/kg body weight (bw) per day, derived from the incidence of rat liver tumours (benign and malignant) induced by NDEA and used in a margin of exposure (MOE) approach. Analytical results on the occurrence of N-NAs were extracted from the EFSA occurrence database (n = 2,817) and the literature (n = 4,003). Occurrence data were available for five food categories across TCNAs. Dietary exposure was assessed for two scenarios, excluding (scenario 1) and including (scenario 2) cooked unprocessed meat and fish. TCNAs exposure ranged from 0 to 208.9 ng/kg bw per day across surveys, age groups and scenarios. 'Meat and meat products' is the main food category contributing to TCNA exposure. MOEs ranged from 3,337 to 48 at the P95 exposure excluding some infant surveys with P95 exposure equal to zero. Two major uncertainties were (i) the high number of left censored data and (ii) the lack of data on important food categories. The CONTAM Panel concluded that the MOE for TCNAs at the P95 exposure is highly likely (98-100% certain) to be less than 10,000 for all age groups, which raises a health concern.

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Section: Dna Adduct Formationmentioning

confidence: 99%

Risk assessment of N‐nitrosamines in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2023

EFS2

View full text Add to dashboard Cite

show abstract

“…They found these compounds to be greater pancreatic carcinogens in Syrian hamsters, while in rats, they had a more significant effect as esophageal and respiratory carcinogens. Furthermore, they found this correlates with DNA alkylation (34). Thus, Syrian hamsters would be a better choice for studying pancreatic cancer compared to rats when using BOP and HPOP to induce carcinogenesis.…”

Section: A N-nitrosobis (2-oxopropyl)amine (Bop) / N-nitroso(2-hydroxypropyl) (2oxopropyl)amine (Hpop)mentioning

confidence: 99%