Differences in epidemiological and clinical features between adult and pediatric tracheobronchial tuberculosis patients in Southwest China

Chen, Qing; Huang, Tao; Zou, Li‐Ping; Jiang, Liangshuang; Sun, Jiying; Lü, Xiaoli; Huang, Xiaoqi; Wu, Guihui; He, Wei‐Ming

doi:10.3389/fpubh.2023.1225267

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…При этом наблюдается увеличение распространенных форм туберкулезного процесса, в т. ч. с поражением трахеобронхиального дерева. Стоит отметить, что многие исследования показывают о высокой распространенности туберкулеза трахеобронхиального дерева среди молодых некурящих женщин трудоспособного возраста [13][14][15]. Кроме того, туберкулез трахеобронхиального дерева часто встречается среди детей и подростков в сочетании с туберкулезом внутригрудных лимфатических узлов (ВГЛУ) в результате эрозии лимфатических узлов [16].…”

Section: Discussionunclassified

Integrated Approach in the Treatment of a Patient with Tuberculosis of the Lungs and Tracheobronchial Tree

Chumovatov,

Komissarova,

Chernyh

2024

Урал. мед. журнал

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Introduction. According to the World Health Organization data for 2021, there is an increase in the incidence of tuberculosis (TB) worldwide. There is also an unfavorable growth trend in drug-resistant TB. One of the complications of the tuberculosis process is tuberculosis of the tracheobronchial tree, which has tended to grow in recent years. Many studiesindicate the incidence of bronchial tuberculosis from 10 to 40 %, taking into account the level of endoscopic service.The purpose of the study to demonstrate the high eﬀectiveness of an integrated approach in the treatment of a patient with tuberculosis of the lungs and tracheobronchial tree.Methods. The materials of the study were: the outpatient card of the advisory department of the Central Tuberculosis Research Institute, the medical history of the inpatient patient and the results of a comprehensive examination.Results. The presented clinical example demonstrates the high eﬀectiveness of an integrated approach in the treatment of a patient with a widespread tuberculosis process using anti-tuberculosis chemotherapy, inhalation and pathogenetic therapy. By 4 months of treatment, pronounced positive clinical and laboratory dynamics was observed, signiﬁcant resorption of focal inﬁltrative changes in the leﬅ lung was achieved radiologically, and endoscopically, inﬁltrative tuberculosis of the trachea, leﬅ main bronchus and leﬅ upper lobe bronchus was cured.Conclusion. This clinical observation demonstrates the need for an integrated approach in the management of this category of patients and shows the high eﬀectiveness of the treatment.

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Section: Discussionunclassified

Integrated Approach in the Treatment of a Patient with Tuberculosis of the Lungs and Tracheobronchial Tree

Chumovatov,

Komissarova,

Chernyh

2024

Урал. мед. журнал

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Clinical outcomes of multidrug-resistant tracheobronchial tuberculosis receiving anti-tuberculosis regimens containing bedaquiline or delamanid

Chen,

Huang,

Zou

et al. 2024

Sci Rep

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The treatment of multidrug-resistant tracheobronchial tuberculosis poses challenges, and research investigating the efficacy of bedaquiline or delamanid as treatment for this condition is limited. This retrospective cohort study was conducted from 2017 to 2021. The study extracted data of patients with multidrug-resistant tracheobronchial tuberculosis from medical records and followed up on prognoses. Participants were divided into three groups: the bedaquiline, delamanid, and control group. Clinical outcomes and the risk factors associated with early culture conversion were analyzed. This study included 101 patients, with 32, 25, and 44 patients in the bedaquiline, delamanid, and control groups respectively. The differences in the treatment success rates among the three groups did not show statistical significance. Both the bedaquiline and delamanid groups had significantly higher culture conversion rates compared to the control after 2 or 6 months of treatment, with significantly shorter median times to culture conversion (bedaquiline group: 2 weeks, delamanid group: 2 weeks, control group: 12 weeks, P < 0.001). Treatment with bedaquiline or delamanid were identified as independent predictors of culture conversion at 2 months (bedaquiline group: aOR = 13.417, 95% CI 4.067–44.260, delamanid group: aOR = 9.333, 95% CI 2.498–34.878) or 6 months (bedaquiline group: aOR = 13.333, 95% CI 3.379–52.610, delamanid group: aOR = 5.000, 95% CI 1.357–18.426) of treatment through multivariable logistic regression analyses. The delamanid group showed better improvement in lumen stenosis compared to bedaquiline. Regimens containing bedaquiline or delamanid may accelerate the culture conversion during the early treatment phase in multidrug-resistant tracheobronchial tuberculosis, and delamanid appears to have the potential to effectively improve airway stenosis.

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Differences in epidemiological and clinical features between adult and pediatric tracheobronchial tuberculosis patients in Southwest China

Cited by 2 publications

References 15 publications

Integrated Approach in the Treatment of a Patient with Tuberculosis of the Lungs and Tracheobronchial Tree

Integrated Approach in the Treatment of a Patient with Tuberculosis of the Lungs and Tracheobronchial Tree

Clinical outcomes of multidrug-resistant tracheobronchial tuberculosis receiving anti-tuberculosis regimens containing bedaquiline or delamanid

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