Differences in microbiota between acute and chronic perianal eczema

Ma, Ming; Lü, Hongmei; Yang, Zuozhen; Chen, Li; Li, Yingru; Zhang, Xiu

doi:10.1097/md.0000000000025623

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…In this study, the authors concluded that, in acute lesions of AD patients, there is a more direct damage to the epidermal skin barrier, mainly through scratching, and S. aureus can more easily penetrate or colonise the skin than in chronic lesions, which can also explain this association in HE patients. Another study showed a similar finding in patients with acute and chronic perianal eczema 23 . This finding may enable a personalised treatment of the patients depending on the clinical symptoms of the disease.…”

Section: Discussionsupporting

confidence: 60%

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The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: The importance of Staphylococcus aureus and presence of commensal skin flora

Chapsa¹,

Rönsch²,

Löwe

et al. 2023

Contact Dermatitis

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BackgroundThe role and causality of the microbial ecosystem on the skin in relation to the development of hand eczema (HE) is still unknown.ObjectivesTo investigate the prevalence of different bacterial colonisations in HE patients and their association with the severity, symptoms and aetiology of the disease.MethodsIn a retrospective cohort study of 167 HE patients, bacterial swabs from lesional skin were collected for culturing. Patients were categorised according to bacterial colonisation, HE severity, HE symptoms and HE aetiology.ResultsThe majority of the patients were tested positive for Staphylococcus aureus (S. aureus) (n = 131, 78.4%) and/or commensal skin flora (CSF; n = 130, 77.8%), while other bacteria species were found only sporadically. Severe HE was significantly more prevalent in skin with S. aureus (odds ratio [OR]: 5.13, 95% confidence interval [CI]: 2.21–11.94) and less common in skin with CSF (OR: 0.20, 95% CI: 0.05–0.88). S. aureus colonisation was also associated with atopic HE aetiology (p < 0.001) and acute HE symptoms such as blisters, erosions and crusts (p = 0.003).ConclusionsThe main colonisation of HE patients is with S. aureus and is associated with disease severity, acute HE symptoms and atopic HE aetiology. CSF is associated with mild HE, which could result in new therapeutic approaches.

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Section: Discussionsupporting

confidence: 60%

“…Another study showed a similar finding in patients with acute and chronic perianal eczema. 23 This finding may enable a personalised treatment of the patients depending on the clinical symptoms of the disease.…”

Section: S Aureus Colonisation and Acute Versus Chronic He Symptomsmentioning

confidence: 95%

The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: The importance of Staphylococcus aureus and presence of commensal skin flora

Chapsa¹,

Rönsch²,

Löwe

et al. 2023

Contact Dermatitis

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“… 9 , 14 Posterior to the vulva, the perineal skin and microbiota are underappreciated modulators of genital health. 15 – 23 …”

Section: The Persisting Language Biasmentioning

confidence: 99%

Maintaining vulvar, vaginal and perineal health: Clinical considerations

Graziottin

2024

Womens Health (Lond Engl)

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Knowledge of female genital anatomy and physiology is often inadequate or incorrect among women. Precise patient–physician conversations can be inhibited by a reluctance or inability to speak accurately about the vulva and vagina, with the terms often being used interchangeably. There is a paucity of scientific evidence and clinical guidelines to support women and physicians in ensuring best practices in feminine hygiene. In this review, the unmet needs in the field are highlighted. Evidence is provided for the complex array of physiological and pathological systems, mechanisms and behaviours that either protect or, if inappropriate, predispose the vulva and vagina to infections, irritation or other conditions. The need for attention to perineal health is recommended, given the interdependence of perineal and vulvar microbiota and the risk of colonic pathogens reaching the vulva and the vagina. Differences in feminine hygiene practices can vary widely across the world and among varying age groups, and suboptimal habits (such as vaginal douching or the use of certain cleansers) can be associated with increased risks of vulvar and vaginal conditions. Critical areas for discussion when advising women on their intimate health include: advice surrounding aesthetic vulvar cosmetic trends (such as depilation and genital cosmetic surgery), bowel health and habits, and protection against sexually transmitted infections. Routine, once-daily (maximum twice-daily) washing of the vulva with a pH-balanced, mild cleanser is optimal, ideally soon after bowel voiding, when feasible. Due to the finely balanced ecosystems of the vulva, the vagina and the perineal area, a scientific and clinical perspective is essential when determining the most appropriate vulvar cleansers based on their components. Correct intimate care may contribute to improved genital and sexual health and overall well-being. An increased awareness of correct practices will empower women to be the advocates of their own intimate health.

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“…The imbalance of gut microbiota can cause a series of diseases, including digestive system diseases, metabolic diseases, inflammatory bowel disease, irritable bowel syndrome, and autoimmune diseases [16][17][18]. Anus is the gateway of digestive tract to the outer body and the perianal diseases are closely related to the microorganisms [19]. At present, the correlations between the perianal abscesses and gut microbiota are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Differences in Gut Microbiota between Healthy Individuals and Patients with Perianal Abscess before and after Surgery

Yin

Luo

Wang

et al. 2023

Mediators of Inflammation

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Surgery is the most important treatment for perianal abscesses. However, the gut microbiota of patients with perianal abscess and the effects of perianal abscess on the gut microbiota after surgery are unknown. In this study, significant changes in interleukin 6 and tumor necrosis factor-α in the blood of healthy subjects, patients with perianal abscesses, and patients after perianal abscess surgery were identified. 16S rRNA gene sequencing technology was used to detect the changes in the gut microbiota among 30 healthy individuals and 30 patients with perianal abscess before and after surgery. Venn diagrams and alpha diversity analyses indicated differences in the abundance and uniformity of gut microbiota between the healthy individuals and patients with perianal abscesses before and after surgery. Beta diversity analysis indicated that the grouping effects among the control, abscess, and surgery groups were good. The classification and compositional analysis showed significant differences in the gut microbiota between healthy individuals and patients with perianal abscesses before and after surgery. LEfSe analysis, random forest analysis, and ROC curve analysis showed that Klebsiella ( AUC = 0.7467 ) and Bilophila ( AUC = 0.72 ) could be potential biomarkers for the diagnosis of perianal abscess. The functional prediction results showed that the differential microbiota is significantly enriched in the pathways related to nutrition and drug metabolism. This study may have important implications for the clinical management and prognostic assessment of patients with perianal abscesses.

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Differences in microbiota between acute and chronic perianal eczema

Cited by 4 publications

References 36 publications

The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: The importance of Staphylococcus aureus and presence of commensal skin flora

The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: The importance of Staphylococcus aureus and presence of commensal skin flora

Maintaining vulvar, vaginal and perineal health: Clinical considerations

Differences in Gut Microbiota between Healthy Individuals and Patients with Perianal Abscess before and after Surgery

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