Differences in perceived stress during ovarian stimulation between women with infertility and those pursing oocyte cryopreservation

Adeleye, Amanda; Cruz, Katrina; Pasch, Lauri A.; Huddleston, Heather G.

doi:10.1016/j.fertnstert.2020.05.025

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…The level of stress and the number of oocytes obtained in ART programs for the treatment of infertility was compared. The results of this study showed a significantly higher level of stress in patients with infertility, but the number of oocytes was comparable in both groups (Adeleye et al, 2020).…”

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confidence: 52%

Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data

et al. 2022

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Modern life, especially in large cities, exposes people to a high level of noise, high density of population, disrupted sleeping, large amount of excessive and controversial information as well as to other negative factors; all this may cause chronic psycho-emotional stress. The latest publications often use the term “Syndrome of megalopolis”, which means disruption of sleeping, high anxiety, and altered reproductive function. Medical treatment of infertility may also be considered as a stress factor, especially when infertility lasts for years and is aggravated with emotional frustration. Long-lasting distress may worsen health in general and suppress reproductive function, in particular. The review presents the data on the effects of maternal stress on folliculogenesis, especially when assisted reproductive technologies (ARTs) are used. Clinical data are presented alongside data from laboratory animal experiments. Different maternal stress models are taken into account in respect of their inf luence on oocyte maturation and embryo development. The interfering of psycho-emotional stress and reproductive function is the focus of the review. In these situations, exogenous hormones compensate for the stress-related disruption of the hypothalamic-pituitary-gonadal axis. When ARTs are implemented, stress-induced disruption of oogenesis is realized not via a decrease in hypothalamic and pituitary hormones, but by other ways, which involve paracrine mechanisms described in this review. Based on the literature analysis, one may conclude that stress negatively affects oocyte maturation in the ovary and suppresses subsequent embryo development. The role of some ovarian paracrine factors, such as BDNF, GDF-9, HB-EGF, TNF-α, and some others has been elucidated.

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confidence: 52%

Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data

et al. 2022

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“…There were no differences in PSS scores collected before and after treatment for each group ( p = 0.94 and 0.25, respectively). For additional analysis comparing pre-treatment and post-treatment PSS scores in the LOVE study cohort, readers may refer to our previously published study on this topic 10 . There was no difference in PSS score between the two groups using an intention to treat analysis for the entire LOVE study cohort ( p = 0.92) (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…We also utilized the Perceived Stress Scale (PSS), which was first developed by Sheldon Cohen et al, 15 , 16 . The PSS has been used in a wide variety of settings and scores are well correlated with other measurements of stress 10 , 17 . The PSS score is based upon a 10-item questionnaire to assess stress in the last month.…”

Section: Methodsmentioning

confidence: 99%

Learning from Online Video Education (LOVE) improves confidence in fertility treatments: a randomized controlled trial

et al. 2022

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Fertility treatments like in vitro fertilization (IVF) or oocyte cryopreservation (OC) require the daily use of injectable gonadotropins and has been associated with treatment burden and attrition from fertility treatment. We conducted a randomized clinical trial to determine (1) whether educational videos about fertility medications improved infertility self-efficacy scale (ISES), fertility quality of life treatment (FertiQoL-T), and Perceived stress scale (PSS) scores and (2) if such videos improved confidence and reduced medication errors during a first ovarian stimulation cycle. Participants were given access to an online portal with randomized access to either placebo control videos focused on an orientation to IVF or experimental videos that reviewed the preparation and administration of medications used during ovarian stimulation in addition to the placebo videos. Participants completed pre and post-treatment questionnaires. 368 patients enrolled and 257 participants completed the study. There were no differences in ISES, FertiQoL-T or PSS scores between the two groups in an intention-to-treat (p = 0.18, 0.72, and 0.92, respectively) or per-protocol analysis (p = 0.11, 0.38, and 0.37, respectively). In the per protocol analysis, participants who watched experimental videos were four-fold more likely to report confidence administering medications OR 4.70 (95% CI: 2.10, 11.1; p < 0.01) and were 63% less likely to make medication errors OR 0.37 (95% CI: 0.14, 0.90; p = 0.03). Participants had similar likelihoods of rating videos as helpful and recommending videos to others (p = 0.06 and 0.3, respectively). Educational videos about fertility medications may not influence psychological well-being but might improve confidence in medication administration and reduce medication errors. Trial registration number: NCT02979990.

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“…Finally, it is important to note that although Adeleye et al (1) indicate that the results of this study could be used to design intervention aimed at reducing stress levels in IVF and OC patients, the authors appropriately do not suggest that these future interventions would improve reproductive outcomes. Rather, they highlight the use of such interventions in decreasing stress levels because stress can lead to psychologic distress.…”

mentioning

confidence: 87%

“…The results of the study by Adeleye et al (1) highlight that patients with an infertility diagnosis reported higher levels of stress than patients pursuing OC. Furthermore, stress levels for IVF patients decreased after trigger injection and before knowledge of pregnancy outcome.…”

mentioning

confidence: 90%

Caution is warranted when discussing correlations between stress and reproductive outcomes

Lawson

2020

Fertility and Sterility

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Differences in perceived stress during ovarian stimulation between women with infertility and those pursing oocyte cryopreservation

Cited by 7 publications

References 21 publications

Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data

Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data

Learning from Online Video Education (LOVE) improves confidence in fertility treatments: a randomized controlled trial

Caution is warranted when discussing correlations between stress and reproductive outcomes

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