Differences in Radiosensitivity Among Tumors Undergoing Stereotactic Body Radiation Therapy to the Lung: Application of gLQ Radiobiologic Modeling

Abstract

18 months respectively. 6 pts (15%) had relapse close to irradiated field. Only one patient had relapse in field and close to treated field. Twenty pts (50%) had progression of distant metastases. Only grade 2 pneumonitis occurred in 2 pts. Two patients had a fistula of the esophagus and bronchus, which occurred in proximity of in field relapse. Conclusion: In our experience the use of Hypofractionated VMAT with high BED 10 values (72-100 Gy)for locally advanced NSCLC appears as effective treatment option with acceptable toxicity ,and High LC rates (89% at 1 year). It is necessary high accuracy in PTV delineation, because mostly we observed the marginal recurrences.