Differences in serum levels of CB-153 and p,p′-DDE, and reproductive parameters between men living south and north in Norway

Haugen, Trine B.; Tefre, Toril; Malm, Gunilla; Jönsson, Bo; Rylander, Lars; Hagmar, Lars; Bjørsvik, Cathrine; Henrichsen, Trine; Sæther, Thomas; Figenschau, Yngve; Giwercman, Aleksander

doi:10.1016/j.reprotox.2011.06.072

Cited by 34 publications

(36 citation statements)

References 57 publications

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“…The study found significantly higher levels of p,p’ -DDE among men living below the Arctic Circle compared to the group living above. Contrary to the other studies in this review, higher levels of p,p’ -DDE were correlated with higher semen concentration ( r =0.25, p =0.03) among men living in the northern region of Norway (Haugen et al, 2011). Serum concentrations of p,p’ -DDE and p,p’- DDT were combined by Messaros et al (2009) to evaluate their associations with semen parameters: high sum p,p’ -DDE and p,p’ -DDT concentrations increased the odds of low sperm concentration, low sperm motility and abnormal morphology.…”

Section: Discussioncontrasting

confidence: 99%

“…Among the 15 studies reporting associations, three (3) studies found significant results for pyrethroid pesticides (Ji et al, 2011; Meeker et al, 2008; Xia et al, 2008). Relationships between the persistent organic pollutants (POPs) DDT and HCH and sperm characteristics were found in five studies (Aneck-Hahn et al, 2007; Haugen et al, 2011; Khan et al, 2010; Messaros et al, 2009; Pant et al, 2007). Organophosphates (OP) were shown to be associated with lowered sperm parameters in six of the studies (Hossain et al, 2010; Perez-Herrera et al, 2008; Perry et al, 2007, 2011; Recio-Vega et al, 2008; Yucra et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…Aneck-Hahn et al (2007) found an increased risk of oligospermia (sperm concentrations below 20 million sperm per milliliter of ejaculate) with increasing levels of p,p’ - DDE and an increased risk of asthenozoospermia (low total sperm motility grades) with increasing levels of p,p’ -DDT and p,p’ -DDE. In a cross-sectional study by Haugen et al (2011), semen parameters were evaluated with respect to blood serum levels of p,p’ -DDE for two groups of men: one group living below the Arctic Circle and one group living above. The study found significantly higher levels of p,p’ -DDE among men living below the Arctic Circle compared to the group living above.…”

Section: Discussionmentioning

confidence: 99%

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Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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Of continuing concern are the associations between environmental or occupational exposures to pesticides and semen quality parameters. Prior research has indicated that there may be associations between exposure to pesticides of a variety of classes and decreased sperm health. The intent of this review was to summarize the most recent evidence related to pesticide exposures and commonly used semen quality parameters, including concentration, motility and morphology. The recent literature was searched for studies published between January, 2007 and August, 2012 that focused on environmental or occupational pesticide exposures. Included in the review are 17 studies, 15 of which reported significant associations between exposure to pesticides and semen quality indicators. Two studies also investigated the roles genetic polymorphisms may play in the strength or directions of these associations. Specific pesticides targeted for study included dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexane (HCH), and abamectin. Pyrethroids and organophosphates were analyzed as classes of pesticides rather than as individual compounds, primarily due to the limitations of exposure assessment techniques. Overall, a majority of the studies reported significant associations between pesticide exposure and sperm parameters. A decrease in sperm concentration was the most commonly reported finding among all of the pesticide classes investigated. Decreased motility was also associated with exposures to each of the pesticide classes, although these findings were less frequent across studies. An association between pesticide exposure and sperm morphology was less clear, with only two studies reporting an association. The evidence presented in this review continues to support the hypothesis that exposures to pesticides at environmentally or occupationally relevant levels may be associated with decreased sperm health. Future work in this area should focus on associations between specific pesticides or metabolic products and sperm quality parameters. Analysis of effects of varying genetic characteristics, especially in genes related to pesticide metabolism, also needs further attention.

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Section: Discussioncontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

2013

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“…2003), and considerably higher compared with Scandinavian levels measured in Northern and Southern Norway in 2001 (66–81 ng/g lipid; Haugen et al . 2011).…”

Section: Discussionmentioning

confidence: 92%

“…Similar findings have been reported independently in subsets of the study populations of two studies assessing the effects of adult male serum levels of p , p ′-DDE on male reproductive health (Toft et al . 2006, Haugen et al . 2011).…”

Section: Discussionmentioning

confidence: 99%

In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

Vested¹,

Ramlau‐Hansen²,

Olsen³

et al. 2014

Reproduction

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Persistent organochlorine pollutants (POPs) are ubiquitous, bioaccumulative compounds with potential endocrine-disrupting effects. They cross the placental barrier thereby resulting in in utero exposure of the developing fetus. The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. During 2008–2009, we recruited 176 male offspring from a Danish cohort of pregnant women who participated in a study in 1988–1989. Each provided semen and blood samples that were analyzed for sperm concentration, total sperm count, motility, and morphology, and reproductive hormone levels, respectively. The maternal blood samples were collected in pregnancy week 30 and were analyzed for the concentrations of six PCBs (PCB-118, -138, -153, -156, -170, and -180) and p,p′-DDE. The potential associations between in utero exposure to ΣPCBs (pmol/ml), Σdioxin like-(DL) PCBs (PCB-118 and -156) (pmol/ml), and p,p′-DDE and semen quality and reproductive hormone levels were investigated using multiple regression. Maternal median (range) exposure levels of ΣPCB, ΣDL-PCB, and p,p′-DDE were 10.0 (2.1–35.0) pmol/ml, 0.8 (0.2–2.7) pmol/ml, and 8.0 (0.7–55.3) pmol/ml, respectively, reflecting typical background exposure levels in the late 1980s in Denmark. Results suggested that in utero exposure to ΣPCB, ΣDL-PCB, and p,p′-DDE was not statistically significantly associated with semen quality measures or reproductive hormone levels. Thus, results based on maternal PCB and p,p′-DDE concentrations alone are not indicative of long-term consequences for male reproductive health; however, we cannot exclude that these POPs in concert with other endocrine-modulating compounds may have adverse effects.

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Human Exposure to Pollutants and Their Health Endpoints: The Arctic Perspective

Odland

Donaldson

2016

Molecular and Integrative Toxicology

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Differences in serum levels of CB-153 and p,p′-DDE, and reproductive parameters between men living south and north in Norway

Cited by 34 publications

References 57 publications

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

Environmental and occupational pesticide exposure and human sperm parameters: A systematic review

In utero exposure to persistent organochlorine pollutants and reproductive health in the human male

Human Exposure to Pollutants and Their Health Endpoints: The Arctic Perspective

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